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System and method for medical imaging

A technology of medical images, objects, applied in the field of medical imaging of the heart, analysis of medical images of the heart

Active Publication Date: 2020-02-11
KINGS COLLEGE LONDON
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Therefore, the results may still require some expert-level analysis

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  • System and method for medical imaging
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  • System and method for medical imaging

Examples

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Embodiment 1

[0076] Detection of ischemia using the system of the invention

[0077] Figure 1A The epicardium of the heart is schematically illustrated, divided into an epicardial layer (1 ) and an endocardial layer (2) surrounding the central blood vessel. First pass CT images, MR images or SPECT images are taken in this direction and signals from individual layers (1, 2) are determined using the system of the invention. This generates many peaks such as Figure 1B with Figure 1C exemplified in . In these graphs, signal intensity-time at a reference point in the left ventricle is shown as a light gray peak (3). The signal intensity-time peak in the epicardial layer (1 ) is shown as a black solid line, and the signal intensity-time peak in the endocardial layer (2) is shown as a dashed line. Although the peak signal intensity in each of these layers can be expected to vary with time compared to the reference point, it can be expected that in a normal heart, the time to peak intens...

Embodiment 2

[0080] Determining the presence of scar tissue and distinguishing CAD from MVD

[0081] According to another aspect of the invention, the system is arranged to be based on measurements taken from a plurality of radial myocardial segments (4, 5, 6 and 7) in a plane similar to that of the slices used in Example 1. measure to get another metric such as Figure 2A exemplified in . In this case, the TTPI index, defined as the difference between the time to peak intensity at the reference point shown by the gray line (8) and the time to peak intensity in all individual radial segments, is at Figure 2B is relatively low, where the TTPI of the individual radial segments 4, 5, 6 and 7 are clearly similar. Where this result occurs after a positive ischemia identification as a result of the analysis of Example 1, this provides an indication that the individual may be suffering from MVD. Alternatively, where the result from Example 1 is negative, this result will confirm that the hea...

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Abstract

A system and for determining the presence or absence of myocardial ischemia in a subject, based upon analysis of medical images of at least one region of the heart of a subject of interest, the plurality of medical images being acquired in a consecutive manner by a medical imaging modality and being a plurality of myocardial layers in a direction which is generally perpendicular to the wall of theleft ventricular myocardium.

Description

technical field [0001] The present invention relates to the field of medical imaging of the heart, and more particularly to the field of analyzing medical images of the heart, to systems, methods and elements for use in this field. Background technique [0002] First-pass enhanced imaging of the heart by cardiac magnetic resonance (CMR) imaging, and more recently also by cardiac computed tomography (CCT) imaging or single photon emission computed tomography (SPECT), allows visualization and quantification of myocardial perfusion. Identification of tissue sites with impaired perfusion is based on image interpretation performed by an expert reader or on quantification of ischemic sites. This quantification includes semi-quantitative or true quantitative analysis of time-intensity curves. Semi-quantitative analysis involves the quantification of several characteristic features of the time-intensity curve (eg peak intensity, maximum upslope, mean transit time, etc.). In true q...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06T7/00
CPCG06T7/0016G06T2207/10072G06T2207/30048G06T2207/30101G06T7/11G16H50/30G16H50/20G06T7/0012G06T2207/10081G06T2207/10088G06T2207/10108G06T2207/20021G06T2207/30104
Inventor A·基里比里
Owner KINGS COLLEGE LONDON
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