Detection of lncRNA and its application in diagnosis and treatment of osteoporosis

A technology of osteoporosis and reagents, applied in the field of biomedicine, can solve problems such as staying at the level of basic research and the development of new treatment methods

Active Publication Date: 2021-06-25
北京市创伤骨科研究所
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Problems solved by technology

However, the pathogenesis of osteoporosis still needs to be further studied, and the current mechanism is still at the level of basic research, which limits the development of new treatment methods

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  • Detection of lncRNA and its application in diagnosis and treatment of osteoporosis
  • Detection of lncRNA and its application in diagnosis and treatment of osteoporosis
  • Detection of lncRNA and its application in diagnosis and treatment of osteoporosis

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Embodiment Construction

[0023] The LOC643072 described in the present invention is located on the zone 4 of the long arm of human No. 2 dye, and the LOC643072 in the present invention includes wild type, mutant type or fragments thereof. In the embodiment of the present invention, the nucleotide sequence of a representative human LOC643072 gene is shown as the LOC643072 gene (NR_110587.1) in the current international public nucleic acid database GeneBank. The full-length nucleotide sequence of LOC643072 or its fragments of the present invention can usually be obtained by PCR amplification, recombination or artificial synthesis.

[0024] The present invention can utilize any method known in the art to measure gene expression. Those skilled in the art will appreciate that the means by which gene expression is measured is not an essential aspect of the invention. Expression levels of biomarkers can be detected at the transcriptional level.

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Abstract

The invention discloses the detection of LncRNA and its application in the diagnosis and treatment of osteoporosis. The lncRNA is LOC643072. The present invention discovers for the first time that the expression of LOC643072 is significantly up-regulated in osteoporosis, and by detecting the expression level of LOC643072, patients with osteoporosis and normal controls can be effectively distinguished. At the same time, LOC643072 can be used as a potential molecular target in the treatment of osteoporosis.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to the detection of lncRNA and its application in the diagnosis and treatment of osteoporosis. The specific lncRNA is LOC643072. Background technique [0002] Osteoporosis is one of the most common age-related diseases and one of the leading causes of fractures. Although there are many international standards for the evaluation and diagnosis of the disease, there are still some details that need to be further improved and improved. Research on the prevention and treatment of osteoporosis has also made some progress. However, the pathogenesis of osteoporosis still needs to be further studied, and the current mechanism research is still at the level of basic research, which limits the development of new treatment methods. At present, it is urgent to further elucidate the pathogenesis of osteoporosis, discover its key targets, provide a reliable theoretical basis for its application in clinic...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6883A61K45/00A61K31/713A61P19/10
CPCA61K31/713A61K45/00A61P19/10C12Q1/6883C12Q2600/158C12Q2600/178
Inventor 吴成爱田伟王超王莹王倩倩张砚卓陶剑锋袁越
Owner 北京市创伤骨科研究所
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