Application of Orciprenaline in antibacterial drugs and method for screening antibacterial drugs

A kind of antibacterial drug and antibacterial drug technology, which is applied in the field of medicine, can solve the problems of antibiotics losing their effectiveness, and achieve the effect of simple and easy operation steps, shortened experiment time, and easy realization

Active Publication Date: 2020-04-10
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, with the abuse of antibiotics, a large number of drug-resistant pathogens are produced, and their rapid spread makes tr...

Method used

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  • Application of Orciprenaline in antibacterial drugs and method for screening antibacterial drugs
  • Application of Orciprenaline in antibacterial drugs and method for screening antibacterial drugs
  • Application of Orciprenaline in antibacterial drugs and method for screening antibacterial drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] This example provides an application of orcinalin, which has bactericidal, antibacterial or bacteriostatic activity, and the application of orcinalin in the preparation of bactericidal, antibacterial or bacteriostatic products.

Embodiment 2

[0056] The present embodiment provides a kind of application of Ossinaline, Ossinaline has bactericidal, antibacterial or bacteriostatic activity, the application of Ossinaline in the preparation of bactericidal, antibacterial or bacteriostatic products, described product is medicine, health product or food.

Embodiment 3

[0058] The present embodiment provides a kind of application of Ossinaline, Ossinaline has bactericidal, antibacterial or bacteriostatic activity, and the application of Ossinaline in the preparation of bactericidal, antibacterial or bacteriostatic drug, described medicine is that Ossinaline is used as The bactericidal, antibacterial or bacteriostatic active ingredients are prepared into any pharmaceutically acceptable preparation.

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PUM

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Abstract

The invention relates to an application of Orciprenaline which has bactericidal, antibacterial or bacteriostatic activity, and application of the Orciprenaline in preparation of bactericidal, antibacterial or bacteriostatic products. A method for screening antibacterial drugs comprises the following steps: constructing a menA defective strain; transferring plasmids containing menA into the defective strain; and screening the medicine to obtain the antibacterial drug. The method has the beneficial effects that the menA defective strains are prepared for the first time, and the drugs are tried to be designed and screened by taking the menA defective strains as targets; it is found that the Orciprenaline has a specific inhibition effect on an important enzyme MenA in a bacterial respiratory chain, which indicates that Orciprenaline has a potential antibacterial effect. The preparation belongs to new use of old drugs, and the drug development period is greatly shortened.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an application of orcinalin in antibacterial drugs and a method for screening antibacterial drugs. Background technique [0002] Antibiotics are a powerful weapon for human beings to fight against bacterial infectious diseases. They have saved countless lives during their 70 years of clinical application. Commonly used antibiotics include β-lactam antibiotics, quinolone antibiotics, aminoglycoside antibiotics, and macrocyclic antibiotics. Lactones etc. However, with the abuse of antibiotics, a large number of drug-resistant pathogens are produced, and their rapid spread makes traditional antibiotics useless, and human health is facing a new crisis, which makes the development of new antibacterial drugs imminent. [0003] In view of this, apply for this patent. Contents of the invention [0004] In order to solve the problems existing in the prior art, the present...

Claims

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Application Information

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IPC IPC(8): A61K31/137A61P31/04C12N15/70C12Q1/18C12R1/19
CPCA61K31/137A61P31/04C12N15/70C12Q1/18G01N2333/245
Inventor 程伟陈斌
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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