Nicotine-oxalate compound crystal and application thereof

An oxalate and compound technology, applied in the field of tobacco chemistry, can solve the problems of excessive oral and respiratory irritation, lack of sustained release effect of nicotine, lack of physiological satisfaction, etc. Increased comfort and safety, improved suction safety

Inactive Publication Date: 2020-04-28
CHINA TOBACCO YUNNAN IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, at present, most heat-not-burn cigarettes or e-cigarettes are added in such a way that nicotine does not have a slow-release

Method used

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  • Nicotine-oxalate compound crystal and application thereof
  • Nicotine-oxalate compound crystal and application thereof
  • Nicotine-oxalate compound crystal and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] 1. Preparation of nicotine-oxalate complex crystals

[0041] 1.1 Preparation of nicotine and oxalic acid complex

[0042] Take 1.57g of oxalic acid in an Erlenmeyer flask, add 20mL of methanol and stir until the solid is completely dissolved. After shading the Erlenmeyer flask, place it in an ultrasonic instrument and add 1.0 mL of nicotine dropwise. After the addition is complete, sonicate until the end of the reaction.

[0043] 1.2 Complex single crystal culture

[0044] Filter the solution obtained after the reaction in step 1.1, place the filtrate in a dark place at room temperature, and let it stand until the crystal grows to obtain a brown-yellow transparent blocky solid.

[0045] 2. Structural characterization of nicotine-oxalate complex crystals

[0046] 2.1 X-ray single crystal diffraction method

[0047] Determination conditions: select a crystal with a suitable size, and use a CCD Xcalibur E X-ray single crystal diffractometer (Bruker, Switzerland) to condu...

Embodiment 2

[0073] A heated cigarette stick containing the above-mentioned nicotine-oxalate complex crystal, including fibers, smokers, non-combustible inorganic fillers, binders and flavors and fragrances;

[0074] The fibers are plant fibers, and the percentage by weight is 30%.

[0075] The fuming agent is a mixture of propylene glycol and glycerin (mass ratio 1:1), with a weight percentage of 30%;

[0076] The non-combustible inorganic filler is calcium carbonate, and the percentage by weight is 10%;

[0077] Adhesive is carboxymethyl cellulose, percentage by weight is 20%

[0078] Add nicotine-oxalate complex crystals to the heated cigarettes, and the added mass of the nicotine-oxalate complex crystals is 1% of the mass of the heated cigarettes.

Embodiment 3

[0080] A heated cigarette stick containing the above-mentioned nicotine-oxalate complex crystal, including fibers, smokers, non-combustible inorganic fillers, binders and flavors and fragrances;

[0081] Described fiber comprises man-made fiber, percentage by weight is 70%.

[0082] The fuming agent is triethylene glycol, and the percentage by weight is 10%;

[0083] The non-combustible inorganic filler is magnesium oxide, and the percentage by weight is 12%;

[0084] The binder is potassium silicate, 6% by weight

[0085] Add nicotine-oxalate complex crystals to the heated cigarettes, and the added mass of the nicotine-oxalate complex crystals is 20% of the mass of the heated cigarettes.

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Abstract

The invention relates to a nicotine-oxalate compound crystal and application thereof, and belongs to the technical field of tobacco chemistry. The molecular formula of the crystal is 2(C10H15N2).C2O4.2.5(C2H2O4). The crystal belongs to a monoclinic system, the space group is C2, and the cell parameters are as follows: a = 10.8406 (15) angstroms, b = 9.8946 (9) angstroms, c = 33.102 (5) angstroms,alpha = 90.00 degrees, beta = 93.481 (13) degrees, gamma = 90.00 degrees and V = 3544.1 (8) angstroms<3>. The nicotine-oxalate compound crystal provided by the invention provides a new introduction form for nicotine of related products such as electronic cigarettes, heat-not-burn cigarettes and the like; when the crystal is used, the taste can be improved, the nicotine delivery process is influenced, and the physiological satisfaction can be continuously provided.

Description

technical field [0001] The invention belongs to the technical field of tobacco chemistry, and in particular relates to a nicotine-oxalate complex crystal and an application thereof. Background technique [0002] At the end of the 20th century and the beginning of the 21st century, with the signing and entry into force of the World Health Organization's "Framework Convention on Tobacco Control" (FCTC), the fourth global wave of smoking bans was set off. The form of tobacco control campaigns has been promoted from the behavior of individuals, organizations or countries to global There are organized and planned unified actions within the scope, and the wave of smoking ban is sweeping every corner of the world. Up to now, there are 177 parties to the WHO Framework Convention on Tobacco Control, covering 88% of the world's population. At the same time, with the continuous improvement of people's living standards, people pay more attention to their physical and mental health and ...

Claims

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Application Information

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IPC IPC(8): C07D401/04C07C51/41C07C55/07A24B15/16A24B15/167
CPCA24B15/16A24B15/167C07B2200/13C07D401/04
Inventor 杨继殷艳飞邹娟刘泽杨柳巩效伟吴俊段沅杏陈永宽缪明明
Owner CHINA TOBACCO YUNNAN IND
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