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Terbium-doped organic framework material, preparation method and application thereof

A technology of organic framework and oxygen atoms, applied in the field of terbium-doped organic framework materials and its preparation, to achieve strong cancer cell inhibitory activity and simple synthesis method

Active Publication Date: 2022-07-01
FUJIAN MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] At present, rare earth metal-organic frameworks (Ln-MOFs) have attracted much attention due to their unique photoelectromagnetic, catalytic, thermal stability properties and topological structure, and have broad application prospects. They have made considerable achievements in the fields of chemistry, synthesis, and materials research. Huge progress, but still few applications in the fields of pharmacy, biology, and medicine

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  • Terbium-doped organic framework material, preparation method and application thereof
  • Terbium-doped organic framework material, preparation method and application thereof
  • Terbium-doped organic framework material, preparation method and application thereof

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Embodiment Construction

[0017] In order to make the content of the present invention easier to understand, the technical solutions of the present invention will be further described below with reference to specific embodiments, but the present invention is not limited thereto.

[0018] HBTA (0.0596 g, 0.2 mmol), malonic acid (0.0218 g, 0.2 mmol), NaOH (0.0160 g, 0.4 mmol) were dissolved in 10 mL of solvent (deionized water: DMF=8:2, v / v), After stirring at room temperature for 30 min, Tb (NO 3 ) 3 ·6H 2 O (0.0045g, 0.1mmol) solid, after mixing, it was placed in a stainless steel reaction kettle of polytetrafluoroethylene and continued to stir for 30min, then after 3 days of constant temperature reaction at 120°C, it was lowered to room temperature at a rate of 5°C / h, and after filtration Rinse with distilled water to obtain C 10 H 12 N 2 O 9 Tb is colorless flaky crystal.

[0019] 1. Single crystal structure analysis

[0020] Under a stereo microscope, select crystals of suitable size, regula...

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Abstract

The invention discloses a terbium-doped organic framework material and a preparation method and application thereof. The chemical formula of the organic framework material is C 10 H 12 N 2 O 9 Tb, which is 1,4-bis(imidazol-1-yl)terephthalic acid, malonic acid, Tb(NO 3 ) 3 ·6H 2 O is the raw material, which is prepared by solvothermal method. The organic frame material prepared by the invention has obvious inhibitory effect on tumor cells, and has little toxicity to normal cells, so it is expected to be developed into a tumor therapeutic drug.

Description

technical field [0001] The invention belongs to the field of medicinal chemistry, and in particular relates to a terbium-doped organic framework material and a preparation method and application thereof. Background technique [0002] At present, rare earth metal organic frameworks (Ln-MOFs) have attracted much attention due to their unique opto-electromagnetic, catalytic, thermally stable properties and topological structures, and have broad application prospects. Huge progress, but still less applied in the fields of pharmacy, biology and medicine. [0003] 1,4-Bis(imidazol-1-yl)terephthalic acid ( , HBTA), is a newly synthesized nitrogen heterocyclic compound, which has certain fluorescence activity, combines the advantages of nitrogen heterocyclic compounds and aromatic polycarboxylic acids, and is rich in N and O coordination sites. Rare earth (Ln 3+ ) metal ions have a unique 4f electronic layer structure, higher positive charges lead to many coordination numbers (8...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07F5/00C09K11/06A61P35/00C08G83/00
CPCC07F5/003C09K11/06A61P35/00C08G83/008C07B2200/13C09K2211/182C09K2211/1044C09K2211/1007
Inventor 孙伟明康杰姚枫枫李祥辉张小玲
Owner FUJIAN MEDICAL UNIV