Application of trans-crocetin in adjustment of alteration of intestinal floras
A technology for regulating intestinal flora and crocus acid, applied in application, medical preparations containing active ingredients, drug combinations, etc., can solve problems such as unsatisfactory, achieve recovery of hippocampal tissue damage, prolong incubation period, Curative effect
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Embodiment 1
[0025] Weigh 1 kg of Gardenia Yellow, add pure water to 80 L, adjust the pH of the solution to 12 with 2M NaOH, leave it at room temperature for 6 hours, and then use 1M H 2 SO 4 The pH of the solution was adjusted to 2, placed at 4°C for overnight suction filtration, and the filtered material was recrystallized three times with methanol: glacial acetic acid (4:1) to obtain the final product - crocetin.
Embodiment 2
[0066] Crocetin is a red powder, insoluble in water, and can be made into tablets, capsules, sustained-release tablets, dripping pills, granules, granules or injections by adding corresponding auxiliary materials.
[0067] Clinically recommended dose of crocetin: 50-250mg / day, orally, 3 times a day.
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