Application of trans-crocetin in adjustment of alteration of intestinal floras
A technology for regulating intestinal flora and crocus acid, applied in application, medical preparations containing active ingredients, drug combinations, etc., can solve problems such as unsatisfactory, achieve recovery of hippocampal tissue damage, prolong incubation period, Curative effect
Active Publication Date: 2020-05-12
HANGZHOU JIURUTANG BIOTECH
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Problems solved by technology
However, the efficacy of most antidepressants currently used does not exceed 40-50%, and remains unsatisfactory due to side effects, including sexual dysfunction, headache, vomiting, and insomnia
Method used
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Experimental program
Comparison scheme
Effect test
Embodiment 1
[0025] Weigh 1 kg of Gardenia Yellow, add pure water to 80 L, adjust the pH of the solution to 12 with 2M NaOH, leave it at room temperature for 6 hours, and then use 1M H 2 SO 4 The pH of the solution was adjusted to 2, placed at 4°C for overnight suction filtration, and the filtered material was recrystallized three times with methanol: glacial acetic acid (4:1) to obtain the final product - crocetin.
Embodiment 2
[0066] Crocetin is a red powder, insoluble in water, and can be made into tablets, capsules, sustained-release tablets, dripping pills, granules, granules or injections by adding corresponding auxiliary materials.
[0067] Clinically recommended dose of crocetin: 50-250mg / day, orally, 3 times a day.
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The invention relates to trans-crocetin with an anti-depression effect and a function of adjusting intestinal flora structures. The trans-crocetin is an effective component extracted from a traditional Chinese medicine material crocus sativus or gardenia yellow, and can repair injury of hippocampi of depressed mice to normalize the number and forms of neuronal cells. Meanwhile, the trans-crocetincan adjust the intestinal flora structures of the depressed mice to make the intestinal flora structures of the depressed mice more similar to those of a normal group. The trans-crocetin can be used for antidepression and adjustment of intestinal floras, is orally administrated, is convenient to take, has small toxic and side effects, and does not cause damage when taken for a long term.
Description
technical field [0001] The present invention relates to the new application of crocetin, in particular to the application of crocetin in the field of pharmacy, specifically the application in the preparation of medicines for intestinal flora regulation. Background technique [0002] Saffron is the upper part and stigma of the saffron (Crocus sativus L.) style of the Iridaceae plant. In 2018, saffron was included in the "New Zhejiang Bawei", so it is of great significance to develop its function. Traditional Chinese medicine believes that saffron is sweet and slightly sour, flat in nature, enters the heart and liver meridian, has the effect of promoting blood circulation and removing blood stasis, dispelling stagnation and resolving knots, and can be used to treat anxiety and depression, chest and diaphragm fullness, vomiting blood, typhoid fever, palpitations, trance, etc. symptom. In my country, the name of saffron first appeared in "Pinhui Jingyao": "The main thing is to...
Claims
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IPC IPC(8): A61K31/194A23L33/10A61P1/00A61P25/22A61P25/24A61P35/00
CPCA61K31/194A61P1/00A61P25/22A61P25/24A61P35/00A23L33/10A23V2002/00A23V2200/3204A23V2200/322
Inventor 王平林素素
Owner HANGZHOU JIURUTANG BIOTECH
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