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The function and application of sh3rf2 in the preparation of drugs for the treatment of non-alcoholic fatty liver disease and/or type 2 diabetes

A non-alcoholic, fatty liver disease technology, applied in the direction of application, drug combination, gene therapy, etc., can solve the problems of aggravated liver damage and achieve the effect of improving fatty liver disease

Active Publication Date: 2021-05-04
WUHAN UNIV
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  • Abstract
  • Description
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Problems solved by technology

On the other hand, if type II diabetes is poorly controlled or fully developed, it will promote the formation of fatty liver and aggravate liver damage

Method used

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  • The function and application of sh3rf2 in the preparation of drugs for the treatment of non-alcoholic fatty liver disease and/or type 2 diabetes
  • The function and application of sh3rf2 in the preparation of drugs for the treatment of non-alcoholic fatty liver disease and/or type 2 diabetes
  • The function and application of sh3rf2 in the preparation of drugs for the treatment of non-alcoholic fatty liver disease and/or type 2 diabetes

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Embodiment Construction

[0025] The present invention will be further elaborated through the following detailed description in conjunction with the accompanying drawings and specific embodiments.

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Abstract

The invention discloses the function and application of Sh3rf2 in the preparation of medicines for treating non-alcoholic fatty liver disease and / or type II diabetes. The present invention takes Sh3rf2 gene knockout mice and wild-type C57 mice as experimental objects, and through the obesity mouse model induced by a high-fat and high-cholesterol diet, it is found that compared with the wild-type C57 mice of the control group, the Sh3rf2 gene knockout mice Body weight gain, mouse liver weight, liver / body weight, and pathological staining of lipid components all showed that the Sh3rf2‑KO mice in the HFHC group had significantly severe fatty liver lesions and increased lipid accumulation. These results indicated that Sh3rf2 gene knockout significantly worsened non Disease course in alcoholic fatty liver disease. Aiming at the above-mentioned effects of Sh3rf2, it can be used to prepare medicines for preventing, alleviating and / or treating non-alcoholic fatty liver disease and / or type II diabetes.

Description

technical field [0001] The invention belongs to the field of gene function and application, and in particular relates to the function and application of (SH3 domain-containingRING finger protein 2, Sh3rf2)Sh3rf2 in the preparation of medicines for treating non-alcoholic fatty liver disease and / or type II diabetes. Background technique [0002] With the increase of aging population, urbanized life and changes in lifestyle, obesity, non-alcoholic fatty liver disease, metabolic syndrome and diabetes and other metabolic abnormalities have increased dramatically, and have now become an important hazard to global public health. [0003] The liver is one of the most important organs of glucose metabolism and the center of substance metabolism. It has many important physiological functions, such as the synthesis and decomposition of glucose, lipid synthesis and decomposition, bile synthesis and secretion, etc. Fatty liver refers to the pathological changes caused by excessive accumu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K48/00C12N15/00A01K67/027
CPCA01K67/0276A01K67/0278A01K2217/072A01K2217/075A01K2227/105A01K2267/0362A61K45/00A61P1/16A61P3/10A61P35/00
Inventor 李红良折志刚姬燕晓杨霞
Owner WUHAN UNIV
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