Treatment method and treatment agent for biological specimen
A technology for biological specimens and treatment methods, applied in the field of biological specimen treatment methods and treatment agents, can solve the problems of horn plug specimen structure damage, microbial loss, difficult research, etc., to reduce trauma, avoid ethical issues, and reduce pain Effect
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Embodiment 1
[0037] The horn plug of acne is a characteristic structure of acne vulgaris, which contains a lot of microbial information, which is of great significance for exploring the etiology and mechanism of acne. The traditional sampling method involves histology, which requires the use of a trephine drill to punch a hole in the skin for a trephine biopsy sample, which is very difficult to accept on the face, which will damage the patient's appearance, cause skin damage and pain, so there is a Ethical issues; even if biopsies can be taken with patient consent, large sample sizes are not possible, hampering studies with large samples.
[0038] If the acne horn plug is separated by non-invasive extrusion method, and there is no suitable coating method for treatment, the integrity of its structure and contained microorganisms cannot be guaranteed by sectioning. Because the horn plug structure is loose and lacks connexin, in the process of traditional embedding method, due to the use of a...
Embodiment 2
[0056] The embedding technology provided by the present invention can not only be used in the preparation of acne horn plug specimens, but also can be widely used in the preparation of other tiny biological tissue specimens. Use smaller specimens, obtain more information, and bring convenience to clinical research and diagnosis.
[0057] In this example, a single pilosebaceous gland with a diameter of only a few hundred microns and a single pilosebaceous gland was successfully coated and sliced using a double coating method similar to that in Example 1. The obtained results are as follows: figure 2 shown. figure 2 The structure and shape of the pilosebaceous glands in the image are very complete, which can reach the image quality obtained by traditional slicing techniques. This work would not have been possible without the use of this method.
[0058] The present invention is used for the coating and processing of extremely small and precious skin and whole body tissue s...
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