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A kind of oligopeptide with antihypertensive effect and its preparation method and application

A technology of oligopeptide and action, which is applied in the field of oligopeptide with antihypertensive effect and its preparation, can solve the problems of uneven distribution of amino acid types and content, achieve good inhibitory effect, uniform distribution, and increase antihypertensive effect

Active Publication Date: 2020-10-09
CHINA YUNHONG HLDG CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Now peptide products are difficult to have most of the amino acid types with the above characteristics, and the amino acid types and contents of this type are unevenly distributed. It is of great significance to target oligopeptide products

Method used

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  • A kind of oligopeptide with antihypertensive effect and its preparation method and application
  • A kind of oligopeptide with antihypertensive effect and its preparation method and application
  • A kind of oligopeptide with antihypertensive effect and its preparation method and application

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Experimental program
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Effect test

Embodiment 1

[0044] The embodiment of the present invention provides a method for preparing an oligopeptide with antihypertensive effect, comprising the following steps:

[0045] A ferments the soybean meal raw material, obtains the fermented soybean meal, and the fermentation strain is butyric acid bacteria;

[0046] B fermenting the fermented soybean meal and squid scraps in step A again, the fermentation strain is butyric acid bacteria, to obtain the mixed base material;

[0047] C performing enzymolysis on the mixed base material in the step B, and adopting ultrasonic-assisted enzymolysis to obtain an enzymolysis solution;

[0048] D. Filtrate, purify, and dry the enzymatic hydrolysis of the step C to obtain an oligopeptide with a hypotensive effect.

[0049] Step A includes the following steps:

[0050] A1. Add pure water to the raw material of soybean meal and stir evenly to obtain soybean meal slurry, wherein the weight ratio of material to water is: 1:0.5;

[0051] A2. Sterilize...

Embodiment 2

[0061] The embodiment of the present invention provides a method for preparing an oligopeptide with antihypertensive effect, comprising the following steps:

[0062] A ferments the soybean meal raw material, obtains the fermented soybean meal, and the fermentation strain is butyric acid bacteria;

[0063] B fermenting the fermented soybean meal and squid scraps in step A again, the fermentation strain is butyric acid bacteria, to obtain the mixed base material;

[0064] C performing enzymolysis on the mixed base material in the step B, and adopting ultrasonic-assisted enzymolysis to obtain an enzymolysis solution;

[0065] D. Filtrate, purify, and dry the enzymatic hydrolysis of the step C to obtain an oligopeptide with a hypotensive effect.

[0066] Step A includes the following steps:

[0067] A1. Add pure water to the raw material of soybean meal and stir evenly to obtain soybean meal slurry, wherein the weight ratio of material to water is: 1:0.5;

[0068] A2. Sterilize...

Embodiment 3

[0078] The embodiment of the present invention provides a method for preparing an oligopeptide with antihypertensive effect, comprising the following steps:

[0079] A ferments the soybean meal raw material, obtains the fermented soybean meal, and the fermentation strain is butyric acid bacteria;

[0080] B fermenting the fermented soybean meal and squid scraps in step A again, the fermentation strain is butyric acid bacteria, to obtain the mixed base material;

[0081] C performing enzymolysis on the mixed base material in the step B, and adopting ultrasonic-assisted enzymolysis to obtain an enzymolysis solution;

[0082] D. Filtrate, purify, and dry the enzymatic hydrolysis of the step C to obtain an oligopeptide with a hypotensive effect.

[0083] Step A includes the following steps:

[0084] A1. Add pure water to the raw material of soybean meal and stir evenly to obtain soybean meal slurry, wherein the weight ratio of material to water is: 1:1.2;

[0085] A2. Sterilize...

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Abstract

The invention discloses an oligopeptide with a blood pressure reducing function, and a preparation method and application thereof, and belongs to the field of biological engineering. According to thetechnical scheme, the preparation method of the oligopeptide with the blood pressure reducing effect comprises the following steps: A, fermenting a soybean meal raw material to obtain fermented soybean meal, wherein the fermentation strain is butyric acid bacteria; B, carrying out secondary fermentation treatment on the fermented soybean meal in the step A with a cuttlefish crushed material to obtain a mixed base material, wherein the fermentation strain is butyric acid bacteria; C, carrying out enzymolysis on the mixed base material in the step B by adopting ultrasonic assisted enzymolysis toobtain an enzymolysis liquid; and D, filtering the enzymolysis liquid obtained in the step C, and performing purification and drying to obtain the oligopeptide with the blood pressure reducing effect. The oligopeptide provided by the invention has the beneficial effects that the selected oligopeptide provided by the invention contains characteristic amino acid for inhibiting the angiotensin I-converting enzyme (ACE), and distribution is uniform. The content of the amino acid is high, so that activity of the provided oligopeptide is high, the inhibition effect on the ACE is good, and the bloodpressure reducing effect is increased.

Description

technical field [0001] The invention relates to the field of bioengineering, in particular to an oligopeptide with hypotensive effect and its preparation method and application. Background technique [0002] Hypertension seriously endangers human health. According to the latest data from the Chinese Center for Disease Control and Prevention, the number of hypertensive patients in my country has exceeded 330 million. Modern medical research shows that angiotensin I-convertingenzyme (ACE) is one of the main factors causing human hypertension. It can convert angiotensin I (Angiotensin I, Ang I) with no pressor activity into angiotensin II (Angiotensin II, AngII) with strong pressor activity, and at the same time inhibit the decomposition of bradykinin with antihypertensive effect , leading to an increase in blood pressure. At present, hypertensive patients often take artificially synthesized ACE inhibitor drugs, such as captopril, arapril, lisinopril, etc., but these synthet...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12P21/00C12P21/06C07K1/34A23J1/04A23J3/34A23J1/00A23L33/18A61K38/01A61P9/12C12R1/01
CPCA23J1/006A23J1/04A23J3/341A23J3/346A23L33/18A23V2002/00A61K38/012A61P9/12C07K1/34C12P21/00C12P21/06A23V2200/326A23V2250/55
Inventor 何静仁李玉保吴东王舒怡
Owner CHINA YUNHONG HLDG CO LTD
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