A device for establishing an animal model of silicosis and its evaluation method

The technology of an animal model and a generating device is applied in the device field of silicosis research, which can solve the problems of complex pathogenesis of silicosis, and achieve the effects of simple and reasonable structure, easy preparation and operation, and low cost.
CN111345245BActive Publication Date: 2022-05-27山东省职业卫生与职业病防治研究院
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
山东省职业卫生与职业病防治研究院
Publication Date
2022-05-27

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Abstract

The invention discloses a device for establishing an animal model of silicosis and an evaluation method thereof. The device is divided into three connected parts from top to bottom. Exhaust gas treatment device; silica dust aerosol generating device is used for silica dust generation, including the tank body and the silica dust stirring device installed in the tank body, and the drain plate installed at the bottom of the tank body; there are upper and lower layers inside the dust dyeing cabinet, The upper layer is a silica dust aerosol mixing device, and the lower layer is a fixed dust collection device for rats; the exhaust gas treatment device has an opening to connect to the filter dust bag; all connections are sealed. The invention also provides a method for establishing and evaluating silicosis animal models through the device. The invention can conveniently and simply establish an effective silicosis animal model, provides a good working basis for the research on the pathogenesis and treatment of silicosis, and provides an objective, direct and reliable standard for the silicosis animal model.
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Description

technical field

[0001] The present invention relates to a device and method for silicosis research, in particular, to a device for establishing an animal model of silicosis and an evaluation method thereof. Background technique

[0002] Silicosis is an occupational disease caused by inhalation of quartz dust in the lungs, and there is inflammation and scarring in the form of pulmonary nodular lesions in the upper lobes. a type of disease. The lungs are one of the main internal organs of the human body. Inhaled air undergoes gas exchange in the alveoli, expelling carbon dioxide, oxygenating the blood, and sending it back to the heart. With the beating of the heart, oxygenated blood is transported to all parts of the body. People suffering from pneumoconiosis have insufficient oxygen in the blood and excessive carbon dioxide due to the obstruction of gas exchange. If this phenomenon persists for a long time, it will lead to right ventricular hypertrophy or pulmonary heart o...

Claims

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