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Lung tumor retention removing formula

A technology of Jifang and Taxus, which is applied in the direction of antineoplastic drugs, pharmaceutical formulas, and medical raw materials derived from gymnosperms, can solve the problems that affect the formulation of standardized diagnosis and treatment of lung cancer, lack of specificity, and insufficient sample size. To achieve the effect of prolonging the progression-free survival period, reducing the quality of symptoms and improving the quality of life

Active Publication Date: 2020-06-30
HEBEI PROVINCE CANGZHOU HOSPITAL OF INTEGRATED TRADITIONAL & WESTERN MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In recent years, Chinese medicine has made great progress in the treatment of lung cancer, but there are still some major problems. For example, the current TCM syndrome classification of lung cancer is relatively scattered, and most of the syndrome types are divided based on personal experience, lacking unified and standardized standards , although it can reflect the distribution of lung cancer syndromes to a certain extent, it is unavoidable to be mixed with individual subjective factors, and the number of patients observed by individuals is limited, so it is difficult to represent and reflect the overall situation. Academic exchanges have also affected the formulation of standardized diagnosis and treatment of lung cancer; in terms of clinical research, research is often limited to one unit or a few units, the sample size is insufficient, and the sample selection lacks randomness, resulting in weak convincing research results , cannot represent the group situation; in terms of experimental research, whether it is immune indicators, trace elements, changes in blood rheology, or new targets, most of them just borrow traditional Chinese medicine to repeat the known pharmacological pathways or apply Western medicine research and development models. The classification of TCM syndromes and the research on the essence of syndromes are not specific; there is a lack of efficacy evaluation criteria after TCM treatment, and the evaluation criteria of solid tumors in Western medicine are not suitable for the embodiment of the advantages of TCM in the treatment of lung cancer, and the actual clinical efficacy There is a big gap, and it is urgent to establish new standards suitable for traditional Chinese medicine

Method used

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Effect test

Embodiment 1

[0026] A lung tumor eliminating accumulation formula provided by the present invention comprises the following traditional Chinese medicines in parts by weight: 10 g of Trichosanthes quinquefolius, 8 g of Pinellia chinensis, 12 g of Fritillaria fritillaria, 18 g of raw coix seed, 8 g of turmeric, 12 g of cat's claw, 4 g of honeycomb, and curcuma 6g, rhodiola 8g, yew 8g.

Embodiment 2

[0028] A lung tumor eliminating accumulation formula provided by the present invention comprises the following traditional Chinese medicines in parts by weight: 14g of Trichosanthes melonis, 12g of Pinellia fragrans, 18g of Fritillaria fritillaria, 22g of raw coix seed, 12g of turmeric, 18g of cat's claw, 8g of hive, and Curcuma 10g, rhodiola 12g, yew 12g.

Embodiment 3

[0030] A lung tumor eliminating accumulation formula provided by the present invention comprises the following traditional Chinese medicines in parts by weight: 12 g of Trichosanthes quinquefolius, 10 g of Pinellia fragrans, 15 g of Fritillaria fritillaria, 20 g of raw coix seed, 10 g of turmeric, 15 g of cat's claw, 6 g of honeycomb, and curcuma 8g, rhodiola 10g, yew 10g.

[0031] The beneficial effects of the present invention are further described below in conjunction with clinical data.

[0032] 1. Method:

[0033] 1. Select 100 patients with advanced non-small cell lung malignant tumors diagnosed with phlegm and blood stasis, all patients came to Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, and were randomly divided into 2 groups by the overall stratified block randomization method, 50 patients in each group. people.

[0034] Criteria for inclusion of cases:

[0035] ①Patients with stage Ⅲb-Ⅳ non-small cell lung cancer diagnosed by patholog...

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Abstract

The invention provides a lung tumor retention removing formula, and particularly relates to a lung tumor retention removing formula for treating stasis-phlegm-type advanced non-small cell lung cancer.In the lung tumor retention removing formula, trichosanthes kirilowii maxim, pinellia ternate and thunberg fritillary bulb are used for clearing lung and reducing phlegm; turmeric and curcuma zedoaryare used for promoting qi circulation, removing stasis and relieving pain; radix ranunculi ternati, honeycomb and taxus chinensis are used for diminishing swelling and resolving masses; rhodiola rosea is used for tonifying qi and clear lung; and unprocessed coix seeds are used for invigorating spleen and removing dampness. The whole formula combines tonification and purgation, dissipates phlegm,removes blood stasis and strengthens body resistance, is reasonable in compatibility, and has reliable clinical curative effect through preliminary observation. According to the research, the progression-free lifetime, the life quality and the traditional Chinese medicine symptom score between two groups are compared; and the effectiveness of the lung tumor retention removing formula in treatmentof stasis-phlegm-type advanced non-small cell lung cancer is verified, a scientific theoretical basis is provided for clinical treatment of lung cancer, and meanwhile, a foundation is established forsubsequent research of discussing the action mechanism of traditional Chinese medicines in treatment of lung cancer from the cytology perspective or the gene perspective.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a lung tumor eliminating accumulation formula for treating advanced non-small cell lung cancer with intermingled phlegm and blood stasis. Background technique [0002] Lung cancer is one of the common malignant tumors. Its morbidity and mortality have risen rapidly in the past 100 years. Chinese medicine has become an important part of lung cancer treatment. Traditional Chinese medicine has shown certain curative effects and advantages in many aspects, such as stabilizing tumor focus, prolonging the survival time with tumor, increasing the immune function of the body, improving clinical symptoms, improving the quality of life, and reducing the side effects of radiotherapy and chemotherapy. In traditional Chinese medicine, lung cancer is classified into categories such as "cough", "lung accumulation", "hemoptysis", "chest pain", "cardiac", "pulmonary gangren...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P35/00A61K35/64
CPCA61K36/428A61K36/8888A61K36/8966A61K36/8994A61K36/9066A61K36/71A61K35/64A61K36/41A61K36/13A61P35/00A61K2300/00
Inventor 王振强张庆江赵阳冉聃马雪梅崔利娜陈晶晶赵芳耿云震
Owner HEBEI PROVINCE CANGZHOU HOSPITAL OF INTEGRATED TRADITIONAL & WESTERN MEDICINE
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