Dopamine hydrochloride injection and preparation method thereof
A technology of dopamine hydrochloride and acid dopamine, applied in the field of medicine, can solve problems such as blindness, circulatory failure, hidden safety hazards, etc., and achieve the effect of increasing stability
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Embodiment 1
[0015] According to the prescription amount in the following table 1, the injection is prepared according to the following method:
[0016] (1) Calcium glycerophosphate and sodium caprylate of prescription quantity are dissolved in 600ml of water for injection at 36 ℃ successively;
[0017] (2) Keep the temperature at 36°C, add the prescribed amount of dopamine hydrochloride and stir to dissolve, add water for injection to 1000ml;
[0018] (3) Measure the pH value and content of the solution, filter it with a 0.22 μm filter membrane, fill it in an ampoule according to the specification of 2ml:20mg, and then sterilize it at 121° C. for 15 minutes to obtain dopamine hydrochloride injection.
[0019] Table 1 Calcium glycerophosphate and sodium caprylate injection in different prescription quantities
[0020]
[0021]
[0022] The above 8 kinds of prescription samples were subjected to the influence factor test, and they were placed under the conditions of 60°C and strong l...
Embodiment 2
[0029] prescription:
[0030] Dopamine Hydrochloride: 10g
[0031] Sodium caprylate: 2.2g
[0032] Calcium glycerophosphate: 4.5g
[0033] Add water for injection to 1000ml to make 500 sticks.
[0034] Preparation:
[0035] (1) Calcium glycerophosphate and sodium caprylate of prescription quantity are dissolved in 600ml of water for injection at 36 ℃ successively;
[0036] (2) Keep the temperature at 36°C, add the prescribed amount of dopamine hydrochloride and stir to dissolve, add water for injection to 1000ml;
[0037] (3) Measure the pH value and content of the solution, filter it with a 0.22 μm filter membrane, fill it in an ampoule according to the specifications, and then sterilize it at 121° C. for 15 minutes to obtain dopamine hydrochloride injection.
Embodiment 3
[0039] prescription:
[0040] Dopamine Hydrochloride: 10g
[0041] Sodium caprylate: 2.2g
[0042] Calcium glycerophosphate: 4.5g
[0043] Add water for injection to 1000ml to make 500 sticks.
[0044] Preparation:
[0045] (1) Calcium glycerophosphate and sodium caprylate of prescription quantity are dissolved in 600ml of water for injection at 42 ℃ successively;
[0046] (2) Keep the temperature at 42°C, add the prescribed amount of dopamine hydrochloride and stir to dissolve, add water for injection to 1000ml;
[0047] (3) Measure the pH value and content of the solution, filter it with a 0.22 μm filter membrane, fill it in an ampoule according to the specifications, and then sterilize it at 121° C. for 15 minutes to obtain dopamine hydrochloride injection.
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