2 results about "Calcium glycerylphosphate" patented technology

The application discloses irbesartan and hydrochlorothiazide tablets and a preparation method thereof. The tablet comprises irbesartan granules and hydrochlorothiazide granules. The irbesartan granules comprise irbesartan, hydroxyphenyl cellulose, glycerophosphoric acid calcium, a disintegrant and a binder. The hydrochlorothiazide granules comprise hydrochlorothiazide, a diluent, a disintegrant and a binder. The tablet can solve the problems of easy agglomeration of irbesartan and hydrochlorothiazide, and difficulty in controlling the content uniformity due to the great difference in the dosage. Meanwhile, the tablet can effectively overcome the poor solubility of irbesartan and hydrochlorothiazide, and good dissolution effect is obtained.

The invention discloses a novel synthesis method of calcium glycerophosphate. The method comprises the following steps: reacting glycidol with a sodium dihydrogen phosphate aqueous solution under an acidic condition to generate an intermediate sodium glycerophosphate, then generating disodium glycerophosphate under an alkaline condition, and finally carrying out a replacement reaction with calcium chloride to obtain a high-purity calcium glycerophosphate product. The process is high in atom economy and small in environmental pollution, the product purity can reach 99.0% or above, and the method is suitable for the fields of medicine, food, feed additives and the like.