The invention discloses a preparation method of glycerophosphate, and belongs to the field of pharmaceutical and
chemical engineering technologies and food
nutrition fortifiers. The preparation method comprises the following steps: (1) adding
glycidol and a phosphating agent into a
solvent for reaction, and treating after the reaction is finished to obtain a glycerophosphate solution; and (2) adding a
metal oxide into the glycerophosphate solution obtained in the step (1), carrying out a stirring reaction, filtering after the reaction is finished, adding
ethanol into the obtained filtrate, crystallizing, filtering and washing to obtain
calcium glycerophosphate. According to the method, the adopted raw materials are simple and easy to obtain, excessive protection is not needed in the reaction process, the reaction
route is short, the reaction is single and
environmentally friendly, and the product yield is high.