27 results about "Sodium caprylate" patented technology

The invention discloses sodium caprylate and a preparation method and application thereof, the sodium caprylate is 8-(2-(2-hydroxyethoxy) benzamido) sodium caprylate, the 8-(2-hydroxybenzamido) sodium caprylate and 2-iodoethanol are subjected to a reaction in an organic solvent containing inorganic base to prepare the sodium caprylate, and the sodium caprylate can be used as a penetration enhancer in an oral administration system. And when the semeglutide oral soluble film is used for preparing the semeglutide oral soluble film, the semeglutide oral soluble film shows a very good in-vitro disintegration effect and a very good permeation promoting effect in animal experiments. The preparation method of the 8-(2-(2-hydroxyethoxy) benzamido) sodium caprylate is simple, does not involve expensive reactants, is convenient for post-treatment, and is beneficial to large-scale production.

The invention belongs to the technical field of pharmacy, and relates to a method for recovering effective components from ampicillin sodium crystallization mother liquor, which comprises the steps of diisopropylamine recovery, ampicillin trihydrate acid recovery and sodium isooctanoate recovery. According to the method, the diisopropylamine, the ampicillin trihydrate and the sodium isooctanoate are effectively recovered from the solvent-method ampicillin sodium crystallization mother liquor, the recovery rates of the diisopropylamine, the ampicillin trihydrate and the sodium isooctanoate recovered by the method are all higher than 80%, and the quality of the recovered product is good. According to the method, various effective components of the ampicillin sodium crystallization mother liquor are effectively recovered, the production cost can be greatly reduced, meanwhile, the discharge amount of sewage is reduced, and the economic benefits and social benefits of enterprises are improved.

The invention belongs to the technical field of medicine preparation, and particularly relates to a preparation method and device of sodium N-(8-[2-hydroxybenzoyl]-amino) caprylate. The preparation method of the sodium N-(8-[2-hydroxybenzoyl]-amino) caprylate comprises the following steps: preparing sodium N-(8-[2-hydroxybenzoyl]-amino) caprylate; the preparation method comprises the following steps: firstly, mixing methyl salicylate with ethyl acetate and 8-amino caprylic acid for reaction, and then carrying out reduced pressure distillation to obtain an N-(8-[2-hydroxybenzoyl]-amino) caprylic acid crude product; and then, adding water to dissolve the crude product, reacting with a sodium hydroxide solution, adding isopropanol to crystallize, recrystallizing with absolute ethyl alcohol, filtering and drying to finally obtain the target product. According to the preparation method, ethyl acetate is selected as a solvent, so that the potential harm to operators is reduced, the environmental protection treatment pressure is relieved, and meanwhile, a good environment is provided for reaction; sodium hydroxide is used as alkali, so that the salt forming reaction can be accelerated, the production efficiency is improved, and the purity and yield of the product are guaranteed.

The invention relates to the technical field of medicines, and provides a semeglutide coated tablet and a preparation method thereof. The chip-coated sheet comprises a chip core layer and a shell layer, the tablet core layer comprises a first absorption enhancer; the shell layer comprises a second absorption enhancer; the first absorption enhancer and the second absorption enhancer are selected from the group consisting of sodium 8-(2-hydroxybenzamido) caprylate, Tween 80, lauryl sodium sulfate, sodium caprate, polyglycerol-3 diisostearate, oleic acid, lauric acid, sodium deoxycholate, sodium cholate, polyoxyethylene (35) castor oil, PEG-vitamin E succinate, PEG-vitamin D3 succinate and pluronic. The invention relates to a preservative which is prepared from the following raw materials: polyethylene glycol, a methoxy polyethylene glycol-polycaprolactone copolymer, sucrose fatty acid ester, 15-hydroxystearic acid polyethylene glycol ester and caprylic / capric acid polyethylene glycol glyceride. The coated tablet provided by the invention adopts a double-layer structure consisting of the tablet core layer and the shell layer, so that the bioavailability of the preparation can be remarkably improved, the oral dosage can be hopefully and greatly reduced, and the medication cost is reduced.

The invention provides a method for preparing human immunoglobulin for intravenous injection by a sodium caprylate precipitation process. Comprising the following steps: raw material plasma preparation, FI reaction, FI + II + III separation, FI + II + III filter pressing, FI + II + III precipitation and dissolution, sodium caprylate precipitation reaction, filter pressing filtration, ultrafiltration concentration, DEAE chromatography, TMAE chromatography, ultrafiltration dialysis, nanofiltration, low-pH incubation, ultrafiltration concentration (stock solution), semi-finished product solution preparation, degerming and split charging to obtain the human immunoglobulin finished product for intravenous injection. According to the process, plasma is adopted as an initial raw material, FI + II + III is prepared through an ethanol reaction, and albumin, IgA, IgM and other impure proteins are removed more thoroughly through a method of sodium caprylate precipitation primary purification and multi-step chromatography refining purification, so that the risk of hemolysis and adverse reaction after infusion is reduced. Meanwhile, saccharides are not added into the preparation as a stabilizer, and safer glycine is used as the stabilizer, so that the kidney load of a patient is reduced.

The invention belongs to the technical field of biological medicine, and discloses a lipopolysaccharide oral absorption enhancer and a preparation method thereof, the lipopolysaccharide oral absorption enhancer comprises a rutabaga aqueous extract and a second accelerator, and the second accelerator is selected from at least one of chitosan, ethanol or sodium caprylate. The oral lipopolysaccharide absorption enhancer can significantly improve the oral absorption enhancing effect of lipopolysaccharide, and lays a foundation for the protection effect of LPS on tumor-associated macrophages after oral administration.

The invention relates to the technical field of biological medicine and cosmetics, and discloses an extraction method of exosomes in a leukocyte extract and application of the exosomes in skin care products, the method comprises the following steps: S1, adding anhydrous betaine into a leukocyte clarification lysate, stirring and dissolving, and constructing a hydration protective layer; s2, sodium caprylate is added, the pH is adjusted to 5.8-6.2, and surface impure protein is replaced; s3, adding polyethylene glycol to carry out low-temperature curing precipitation; and S4, redissolving and precipitating by using a phosphate buffer solution containing L-arginine, and dialyzing and filtering by using a tangential flow filtering system to obtain the L-arginine. By utilizing the synergistic effect of zwitterionic ionization and fatty acid salt replacement, the problems that exosomes are easy to agglomerate and difficult to redissolve and coprecipitation of impure proteins is serious in a traditional precipitation method are solved; the obtained exosome extract is high in purity and good in monodispersity, can be efficiently absorbed in a transdermal mode, has good skin barrier repairing and anti-inflammatory effects, and is suitable for preparing skin care products with the skin barrier repairing and anti-inflammatory effects.

This invention provides a bioactive liquid adhesive mimicking cell mucus, its preparation method, and its applications. First, sodium thiooctanoate is dissolved in water and self-assembled into nanomicelles using its amphiphilic and concentration-dependent ring-opening polymerization ability, which then polymerizes to form sodium polythiooctanoate. Next, thioctic acid powder is added to the system. A stable thioctic acid-based liquid adhesive is prepared by relying on the solubilization of thioctic acid by the sodium thiooctanoate nanomicelles and the hydrogen bonding interaction between the two monomer chains. The bioactive liquid adhesive mimicking cell mucus prepared using this method is simple to prepare and simultaneously possesses good tissue adhesion ability, excellent reactive oxygen species scavenging ability, and physical barrier function. It can be applied to treat intestinal inflammatory diseases caused by flora imbalance or oxidative stress.

The invention relates to diquafosol sodium eye drops and a preparation method thereof. Every 1000 ml of the diquafosol sodium eye drops contain 30 g of diquafosol sodium, xylitol and sodium caprylate, preferably, each 1000 ml of the diquafosol sodium eye drops contain 5.2 g of xylitol and 2.8 g of sodium caprylate, and can also contain 3.5 g of aspartic acid, 0.075 g of benzalkonium chloride, 1.2 g of potassium chloride and 3.1 g of sodium chloride, and the diquafosol sodium eye drops prepared according to the prescription process have extremely high quality stability, and can be used for preparing the eye drops. The effectiveness of medication is improved and is obviously superior to that in the prior art.

The invention discloses a synthesis method of high-purity pharmaceutical adjuvant sodium caprate, and relates to the technical field of pharmaceutical adjuvant synthesis, and the synthesis method comprises the following steps: S1, preparing raw materials; s2, synthesizing sodium caprate; s3, performing pretreatment; s4, separation and purification; s5, elution and collection; and S6, carrying out post-treatment. According to the synthesis method of the high-purity pharmaceutical adjuvant sodium decanoate, in the separation and purification link, an ion exchange resin technology is utilized, and ion impurities including inorganic ions and other organic impurities in a sodium decanoate solution can be efficiently removed, so that the purity of the product is improved, and the production cost is reduced. And the ion exchange resin can selectively remove or retain some ions according to needs, so that the accurate control of the sodium caprate solution is realized, and the content and purity of sodium caprate in a final product can be ensured to meet the requirements of pharmaceutic adjuvants.

The invention relates to the technical field of combustion catalysts, in particular to a bismuth resorcinate combustion catalyst and a preparation method thereof.The preparation method comprises the steps that resorcinic acid is dissolved into a sodium resorcinate solution with an alkaline sodium-containing compound solution, and then the sodium resorcinate solution and a bismuth nitrate solution are heated and then conveyed to an ultrasonic mixing reactor; and carrying out aging, filtering, washing and vacuum drying on the bismuth resorcinate precipitate so as to obtain the combustion catalyst. Reacting liquid generates bismuth resorcinate precipitate under the synergistic effect of screen mesh macromixing and ultrasonic micromixing in the mixer.

The invention provides a method for removing IgA (Immunoglobulin A) and IgM (Immunoglobulin M) in human immunoglobulin for intravenous injection. The method comprises the following steps: S1) dissolving plasma component II + III precipitates to obtain a dissolved solution; s2) precipitating and centrifuging the dissolved solution by adopting n-caprylic acid or sodium caprylate to obtain supernate; s3) performing anion exchange column chromatography on the supernate to obtain first flow-through liquid and first washing liquid; s4) mixing the first flow-through liquid with the first washing liquid to obtain a column chromatography collection liquid; s5) performing strong anion membrane chromatography on the column chromatography collection liquid to obtain second flow-through liquid and second washing liquid; s6) mixing the second flow-through liquid and the second washing liquid to obtain a membrane chromatography collection liquid, and S7) sequentially performing first concentration, dialysis, first sterilization, incubation, ultrafiltration and second sterilization on the membrane chromatography collection liquid to obtain the human immunoglobulin for intravenous injection without IgA and IgM. According to the method disclosed by the invention, the IgA and IgM removal efficiency is remarkably improved through a multi-stage purification process.

The invention provides a crystal form of 8-(2-hydroxybenzamido) sodium caprylate and a preparation method thereof. The 8-(2-hydroxybenzamido) sodium caprylate crystal forms NX-I and NX-II are good in stability and high in purity, the preparation method is simple, a crystallization system does not form gel, the refining and impurity removing effects are good, the product granularity is large, the fluidity is good, and industrial production and preparation development are facilitated.

The invention provides a method for purifying an antibody by using Protein A affinity chromatography and application of the method, and the method comprises the following steps: loading a supernatant solution to be purified into a Protein A affinity chromatography medium, and sequentially carrying out leaching and elution for three times to obtain the purified antibody. The method comprises the following steps: adding sodium caprylate into a supernatant solution; or sodium caprylate, a combination of sodium caprylate and NaCl and a combination of sodium caprylate and Arg-HCl are added into the leacheate, so that the host protein and esterase removal capability of Protein A affinity chromatography is improved. According to the antibody purification method, the host protein and esterase removal capacity of Protein A affinity chromatography can be effectively enhanced on the premise that the recovery rate is guaranteed and the polymer removal capacity is not reduced, the technological process of the method is stable and controllable, the method can effectively reduce impurity residues in drugs, and the method is suitable for industrial production. The effective guarantee is provided for the safety and the stability of the medicine.

The preparation method comprises the following steps: by taking epoxy fatty acid methyl ester and sodium lipoate as precursors and utilizing acrylic acid rosin as a ring opening agent and a cross-linking agent at the same time, inducing ring opening polymerization of the epoxy fatty acid methyl ester to form a polyester network; meanwhile, disulfide bonds of the sodium lipoate are promoted to break and polymerize to form a sodium polylipoate network, so that the conductive self-healing dual-network gel is obtained. The preparation method is simple and efficient, and the obtained gel has good conductivity and repeatable self-repairing characteristics.

The present invention belongs to the field of biomedicine, and specifically relates to a composition of chondroitin sulfate oligosaccharide and its application in preparing a drug for treating Parkinson's disease; the chondroitin sulfate oligosaccharide is a chondroitin sulfate octose with the sulfate group at position 6 removed and the sulfate group at position 4 specifically retained; the chondroitin sulfate oligosaccharide oral preparation contains N A composition of sodium ‑(8‑[2‑hydroxybenzoyl]‑amino) caprylate (SNAC) and chondroitin sulfate octasaccharide retaining the sulfate group at position 4. N Sodium ‑(8‑[2‑hydroxybenzoyl]‑amino) caprylate can effectively promote the oral absorption of chondroitin sulfate and can be used as an oral absorption enhancer; the chondroitin sulfate oligosaccharide has neuroprotective activity and can be used to treat Parkinson's disease.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to cefixime granules and a preparation method thereof. The cefixime granules provided by the invention are prepared from cefixime, a dissolution-promoting and stability-maintaining agent and pharmaceutically acceptable auxiliary materials, wherein the dissolution-promoting and stability-maintaining agent is a combination of sodium caprylate and meglumine; meanwhile, the dissolution-promoting stability-maintaining agent and the cefixime are subjected to a specific pretreatment process, and then the cefixime particles are prepared through a wet granulation process. According to the technical scheme, the dissolution performance and the stability of the cefixime granules are synergistically optimized, and the preparation process is simple, convenient and controllable, does not need to depend on a special high-energy-consumption process, has relatively high industrial feasibility and is beneficial to large-scale production and market promotion.

The invention provides a method for preparing human immunoglobulin (20%) for hypodermic injection by a sodium caprylate precipitation process. The method comprises the following steps: raw material plasma preparation, FI reaction, FI + II + III separation, FI + II + III precipitation dissolution, sodium caprylate precipitation reaction, pressure filtration, ultrafiltration concentration, DEAE chromatography, TMAE chromatography, ultrafiltration dialysis, nanofiltration, low-pH incubation, SPTFF ultrafiltration concentration, semi-finished product liquid preparation, sterilization and subpackage. According to the process, plasma is adopted as an initial raw material, through the methods of sodium caprylate precipitation primary purification and multi-step chromatography refining purification, albumin, IgA, IgM and other impure proteins are removed more thoroughly, and the risk of hemolysis and adverse reaction after infusion is reduced; and meanwhile, SPTFF (unidirectional tangential flow filtration) is adopted for ultrafiltration concentration, so that the shearing force of a traditional TFF ultrafiltration membrane bag on the product can be reduced, and the method has outstanding advantages in the aspect of pressure control and can improve the recovery rate of the product.

A PFAS-free polymer processing aids mixture, comprising from 2.0 to 40.0 wt.% of one or more inorganic agents based on the total weight of the PFAS-free polymer processing aids mixture wherein the one or more inorganic agents are selected from the group consisting of montmorillonite, zeolite, silica, barium sulfate, calcium silicate, calcium sulfide, silicon dioxide, zinc oxide, aluminum oxide, magnesium oxide, neodymium oxide, and boron nitride; and two or more organic metal salts selected from calcium stearate, zinc stearate, barium stearate, aluminum monostearate, potassium stearate, magnesium stearate, sodium stearate, zinc acetate, sodium acetate, sodium caprylate, sodium laurate, sodium behenate, sodium 1-decane sulfonate, and sodium dodecyl sulfate.

The invention relates to the technical field of medicines, and provides a preparation method of sodium 8-(2-hydroxybenzamido) octanoate, aiming at the problems of complicated synthesis steps and low product purity of the sodium 8-(2-hydroxybenzamido) octanoate. The reaction route is as follows: the compound II is 8-amino caprylic acid salt, and X in the formula is HCl, 1 / 2 H2SO4 or 1 / 3 H3PO4; the compound III is salicylate, and in the formula, R is methyl or ethyl; the compound I is 8-(2-hydroxybenzamido) sodium caprylate. The method is a one-step synthesis method, the route is short, the used raw materials are cheap and easy to obtain, the cost is low, and the method has important industrial application value.

The invention belongs to the technical field of slow-release degradable bone cement for bone defect repair, and particularly relates to slow-release degradable bone cement loaded with an anti-osteoporosis drug and application. According to the bone cement disclosed by the invention, calcium phosphate bone cement powder is used as a solidification material, and the psoralen and / or isopsoralen-loaded PLGA microspheres are added, so that the bone cement obtains a drug slow release duration of at least 16 weeks. By further adding chitosan, the early release of the medicine can be reduced, and the accumulation release rate of the medicine is increased. After the sodium caprylate is added to fill the bone defect part, the osteoblast activity and the whole-body bone mineral density can be improved. The bone cement is long in slow release time, low in early release rate and suitable for bone defect repair of osteoporosis patients.

The invention discloses a method for preparing horse-derived immune globulin F (ab ') 2 by a sodium caprylate precipitation process, and belongs to the technical field of biological pharmacy and plasma immune globulin separation and purification. According to the method, horse source immune plasma is used as a raw material, enzymatic hydrolysate containing immune globulin F (ab ') 2 is obtained through protease enzymolysis, sodium caprylate is added to serve as a selective precipitator, non-target impure protein is selectively precipitated, and target protein F (ab') 2 is kept in the solution. After a clear feed liquid is obtained through solid-liquid separation, membrane separation or chromatographic purification treatment can be further carried out according to needs, and a horse-derived immunoglobulin F (ab ') 2 product is obtained. The precipitate formed by the invention is suitable for industrial filtration operation, solves the problems of low recovery rate of the existing ammonium sulfate precipitate and difficulty in filtration of the free octanoic acid precipitate, improves the feasibility and stability of the process, and improves the product recovery rate.

The invention relates to the technical field of quality control of human albumin preparations, in particular to a method and a kit for simultaneously detecting acetyltryptophan and sodium caprylate in human albumin. The invention relates to a liquid phase method for simultaneously detecting acetyltryptophan and sodium caprylate in a human albumin preparation. The following chromatographic conditions are adopted: a chromatographic column is an HILIC chromatographic column; mobile phases: a phase A is pure acetonitrile, and a phase B is an acetate buffer solution; the flow rate is 0.3 to 0.8 mL / min; the column temperature is 25-50 DEG C; the sample size is 10-15 [mu] L; the adopted elution procedure is as follows: 0-3 min, A: 95%, and B: 5%; in 3.1-6 min, A accounts for 95%-80%, and B accounts for 5%-20%; 6.1-10 min, A accounts for 80%-60%, and B accounts for 20%-40%; in 10.1-15min, A accounts for 60%-95%, and B accounts for 40%-5%. The method is low in detection limit and high in sensitivity, and a new thought is provided for quality control of the human albumin preparation.

Provided herein are improved methods of purifying an Fc-containing protein from a mixture comprising an Fc-containing protein and one or more host cell proteins (HCPs). The methods generally involve applying the mixture to a chromatography column comprising a protein A chromatography matrix, and washing the chromatography matrix with a sodium caprylate wash buffer.

The invention discloses a novel synthesis method of 8-(2-hydroxybenzamido) sodium caprylate, and belongs to the technical field of medicine synthesis. Comprising the following steps: cyclizing suberic acid and acetic anhydride, and performing ring opening with alcohol to obtain a compound 2; the compound 2 reacts with ammonium bicarbonate under activation of di-tert-butyl dicarbonate to obtain a compound 3; carrying out imidization on the compound 3 and di-tert-butyl dicarbonate ester to obtain a compound 4; reducing the compound 4 under the condition of sodium borohydride and boron trifluoride tetrahydrofuran to obtain a compound 5; deprotecting the compound 5 in acid to obtain a compound 6; carrying out condensation reaction on the compound 6 and a salicylic acid derivative in the presence of alkali to obtain a compound 7; and hydrolyzing the compound 7 in alkali to obtain SNAC. The method has the advantages of cheap and easily available main raw materials, high yield in each step, low total cost, mild conditions and simple operation, and is suitable for large-scale industrial production; according to the method, multiple products can be obtained, the product purity is high, the product line is flexible, and the method has good application prospects.