7 results about "Sodium caprylate" patented technology

The invention belongs to the technical field of biological medicine, and discloses a lipopolysaccharide oral absorption enhancer and a preparation method thereof, the lipopolysaccharide oral absorption enhancer comprises a rutabaga aqueous extract and a second accelerator, and the second accelerator is selected from at least one of chitosan, ethanol or sodium caprylate. The oral lipopolysaccharide absorption enhancer can significantly improve the oral absorption enhancing effect of lipopolysaccharide, and lays a foundation for the protection effect of LPS on tumor-associated macrophages after oral administration.

This invention provides a bioactive liquid adhesive mimicking cell mucus, its preparation method, and its applications. First, sodium thiooctanoate is dissolved in water and self-assembled into nanomicelles using its amphiphilic and concentration-dependent ring-opening polymerization ability, which then polymerizes to form sodium polythiooctanoate. Next, thioctic acid powder is added to the system. A stable thioctic acid-based liquid adhesive is prepared by relying on the solubilization of thioctic acid by the sodium thiooctanoate nanomicelles and the hydrogen bonding interaction between the two monomer chains. The bioactive liquid adhesive mimicking cell mucus prepared using this method is simple to prepare and simultaneously possesses good tissue adhesion ability, excellent reactive oxygen species scavenging ability, and physical barrier function. It can be applied to treat intestinal inflammatory diseases caused by flora imbalance or oxidative stress.

The invention provides a method for removing IgA (Immunoglobulin A) and IgM (Immunoglobulin M) in human immunoglobulin for intravenous injection. The method comprises the following steps: S1) dissolving plasma component II + III precipitates to obtain a dissolved solution; s2) precipitating and centrifuging the dissolved solution by adopting n-caprylic acid or sodium caprylate to obtain supernate; s3) performing anion exchange column chromatography on the supernate to obtain first flow-through liquid and first washing liquid; s4) mixing the first flow-through liquid with the first washing liquid to obtain a column chromatography collection liquid; s5) performing strong anion membrane chromatography on the column chromatography collection liquid to obtain second flow-through liquid and second washing liquid; s6) mixing the second flow-through liquid and the second washing liquid to obtain a membrane chromatography collection liquid, and S7) sequentially performing first concentration, dialysis, first sterilization, incubation, ultrafiltration and second sterilization on the membrane chromatography collection liquid to obtain the human immunoglobulin for intravenous injection without IgA and IgM. According to the method disclosed by the invention, the IgA and IgM removal efficiency is remarkably improved through a multi-stage purification process.

The invention relates to the technical field of medicines, and provides a preparation method of sodium 8-(2-hydroxybenzamido) octanoate, aiming at the problems of complicated synthesis steps and low product purity of the sodium 8-(2-hydroxybenzamido) octanoate. The reaction route is as follows: the compound II is 8-amino caprylic acid salt, and X in the formula is HCl, 1 / 2 H2SO4 or 1 / 3 H3PO4; the compound III is salicylate, and in the formula, R is methyl or ethyl; the compound I is 8-(2-hydroxybenzamido) sodium caprylate. The method is a one-step synthesis method, the route is short, the used raw materials are cheap and easy to obtain, the cost is low, and the method has important industrial application value.

The invention discloses a method for preparing horse-derived immune globulin F (ab ') 2 by a sodium caprylate precipitation process, and belongs to the technical field of biological pharmacy and plasma immune globulin separation and purification. According to the method, horse source immune plasma is used as a raw material, enzymatic hydrolysate containing immune globulin F (ab ') 2 is obtained through protease enzymolysis, sodium caprylate is added to serve as a selective precipitator, non-target impure protein is selectively precipitated, and target protein F (ab') 2 is kept in the solution. After a clear feed liquid is obtained through solid-liquid separation, membrane separation or chromatographic purification treatment can be further carried out according to needs, and a horse-derived immunoglobulin F (ab ') 2 product is obtained. The precipitate formed by the invention is suitable for industrial filtration operation, solves the problems of low recovery rate of the existing ammonium sulfate precipitate and difficulty in filtration of the free octanoic acid precipitate, improves the feasibility and stability of the process, and improves the product recovery rate.

The invention relates to the technical field of quality control of human albumin preparations, in particular to a method and a kit for simultaneously detecting acetyltryptophan and sodium caprylate in human albumin. The invention relates to a liquid phase method for simultaneously detecting acetyltryptophan and sodium caprylate in a human albumin preparation. The following chromatographic conditions are adopted: a chromatographic column is an HILIC chromatographic column; mobile phases: a phase A is pure acetonitrile, and a phase B is an acetate buffer solution; the flow rate is 0.3 to 0.8 mL / min; the column temperature is 25-50 DEG C; the sample size is 10-15 [mu] L; the adopted elution procedure is as follows: 0-3 min, A: 95%, and B: 5%; in 3.1-6 min, A accounts for 95%-80%, and B accounts for 5%-20%; 6.1-10 min, A accounts for 80%-60%, and B accounts for 20%-40%; in 10.1-15min, A accounts for 60%-95%, and B accounts for 40%-5%. The method is low in detection limit and high in sensitivity, and a new thought is provided for quality control of the human albumin preparation.