Liver cancer diagnostic marker, kit and application of liver cancer diagnostic marker

A technology of diagnostic markers and kits, applied in the field of biomedical diagnosis, to achieve high detection sensitivity, improve early diagnosis and prognosis of HCC, and induce cell apoptosis
CN111534589AInactive Publication Date: 2020-08-14BEIJING TONGREN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BEIJING TONGREN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
Publication Date
2020-08-14
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention determines that DcR3 protein can be used as a marker for detecting liver cancer, and provides application of the DcR3 protein which is used for preparing a reagent or a kit for detectingliver cancer molecules. The reagent is a specific reagent corresponding to the DcR3 protein, and certain immune cells suitable for targeted knockdown of expression of the DcR3 can be used to inhibitliver tumors and include CAR-T cells, CIK cells and / or NK cells; and similarly, the reagent can specifically inhibit compound or antibody of the DcR3 and can be used as an inhibitor for inhibiting liver tumors. The kit is used for liver cancer detection, is high in sensitivity, strong in specificity, rapid, simple and convenient, and will become an important means for early diagnosis and prognosisprediction of liver cancer. In addition, precise medical treatment can be realized by targeted knock-down of expression of the DcR3 protein.
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Description

Technical field

[0001] The invention relates to the technical field of biomedical diagnosis, in particular to the application of a liver cancer diagnostic marker, a kit and the liver cancer diagnostic marker. Background technique

[0002] Hepatocellular carcinoma (HCC) is one of the common malignant tumors in my country. Because of its insidious onset, early diagnosis is difficult, it often progresses to the middle and late stage at the time of treatment, and it is often accompanied by intrahepatic metastasis, and the treatment effect is poor. The reason is the lack of effective early diagnosis methods, so the early diagnosis of HCC has always been a research hotspot. At present, alpha fetoprotein (AFP) has been used for early diagnosis of HCC, but its sensitivity and specificity are not high. Studies have confirmed that the accuracy of using AFP alone to diagnose HCC is only 60%, especially for early HCC, its diagnostic sensitivity is greatly reduced; at the same time, patients...

Claims

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