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Application of traditional Chinese medicine composition in preparation of medicine for treating or preventing coronavirus infection

A technology of coronavirus, composition, applied in the field of disease treatment drugs

Active Publication Date: 2020-09-01
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no effective vaccine and drug to prevent and treat it, so it is particularly urgent to find effective drugs against the virus

Method used

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  • Application of traditional Chinese medicine composition in preparation of medicine for treating or preventing coronavirus infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The preparation of embodiment 1 Chinese medicine composition granule

[0027] Raw material ratio: Houttuynia cordata: 750g, honeysuckle 750g, red peony root 450g, mugwort leaves 300g, mint 150g.

[0028] Step A: Add 12 times the amount of 50% ethanol to the honeysuckle, reflux extraction twice, each time for 0.5 hours, filter, combine the filtrate, reduce pressure (-0.07MPa~-0.09MPa, 65°C~75°C) to reclaim ethanol and concentrate to Thick paste with a relative density of 1.20-1.25 (65°C), dried under reduced pressure (-0.07MPa--0.09MPa, 60°C-65°C), and pulverized to obtain alcohol-extracted part dry extract powder;

[0029] Step B: Add 8 times the amount of water to Houttuynia cordata, mugwort leaves, and mint, steam distillation to extract volatile oil, extract for 5 hours, filter the extract, store in another container, and set aside;

[0030] Step C: The obtained volatile oil was ground and clathrated with 10 times the amount of β-cyclodextrin and 20 times the amount...

Embodiment 2

[0032] The preparation of embodiment 2 Chinese medicine composition buccal tablet

[0033] Raw material ratio: Houttuynia cordata: 560g, honeysuckle 560g, red peony root 450g, mugwort leaves 275g, mint 275g.

[0034] Step A: Weigh the Chinese medicinal materials according to the weight ratio of the raw materials, cleanly select the honeysuckle, coarsely crush the Radix Paeoniae Rubra, crush the whole mint herb, and directly use Houttuynia cordata and Artemisia argyi for later use;

[0035] Step B: Flos Lonicerae is reflux extracted twice with 12 times the amount of 50% ethanol, each time for 0.5h, the extracts are combined and filtered, and the ethanol is recovered to obtain extract 1, the specific gravity is 1.20-1.30 (60-80°C), dried, and dried Cream powder 1, spare;

[0036] Step C: Add 8 times the amount of water, heat to 80°C, add Houttuynia cordata, mugwort leaves, and mint in turn, extract the volatile oil for 5 hours to obtain volatile oil, add red peony powder to the...

Embodiment 3

[0038] The preparation of embodiment 3 Chinese medicine composition spray

[0039] Proportion of raw medicinal materials: Houttuynia cordata 350g, honeysuckle 350g, red peony root 280g, mugwort leaves 150g, mint 150g.

[0040] Step A: Weigh the Chinese medicinal materials according to the weight ratio of the raw materials, cleanly select the honeysuckle, coarsely crush the red peony root, crush the whole mint herb, and directly use the Houttuynia cordata and Artemisia argyi for later use;

[0041] Step B: Flos Lonicerae is reflux extracted twice with 12 times the amount of 50% ethanol, each time for 0.5h, the extracts are combined and filtered, the ethanol is recovered to obtain extract 1, the specific gravity is 1.20-1.30 (60-80°C), and thick extract 1 is obtained ,spare;

[0042] Step C: Add 8 times the amount of water, heat to 80°C, add Houttuynia cordata, mugwort leaves, mint in turn, extract volatile oil for 5 hours, add red peony powder to the dregs, add 10 times the amou...

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Abstract

The invention discloses application of a traditional Chinese medicine composition in preparation of a medicine for treating or preventing coronavirus infection. The traditional Chinese medicine composition is characterized by being prepared from 5-30 parts of herba houttuyniae, 5-30 parts of honeysuckle flowers, 5-20 parts of radix paeoniae rubra, 3-15 parts of folium artemisiae argyi and 3-15 parts of herba menthae. According to the invention, the inhibition effect of the traditional Chinese medicine composition on the novel coronavirus SARS-CoV-2 under different concentrations is investigated on Vero cells; experimental results show that under the concentrations of 3000 [mu] g / ml, 1000 [mu] g / ml and 200 [mu] g / ml, the traditional Chinese medicine composition shows a good protective effect on Vero cells infected with SARS-CoV-2 viruses, can inhibit replication of SARS-CoV-2 in cells, and enables infected cells not to have lesions, which indicates that the traditional Chinese medicinecomposition has a good effect of treating or preventing coronavirus-related diseases.

Description

technical field [0001] The invention relates to the field of medicines for treating diseases, and more specifically, relates to the application of a traditional Chinese medicine composition in the preparation of medicines for treating or preventing coronavirus infection. Background technique [0002] On March 11, 2020, the World Health Organization (WHO) officially classified COVID-19 as a global pandemic. At present, there is no effective vaccine and drug to prevent and treat it, so it is particularly urgent to find an effective drug against the virus. Traditional Chinese medicine has a long history in the treatment of plague and has played a major role in the prevention and control of various epidemics. The Shuangyu granules involved in the present invention are refined by extracting the active ingredients in Houttuynia cordata, honeysuckle, red peony root, mugwort leaf and mint by modern technology, and can significantly improve dryness of the throat and throat caused by...

Claims

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Application Information

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IPC IPC(8): A61K36/78A61P31/14A61P11/00
CPCA61K36/78A61K36/355A61K36/71A61K36/65A61K36/282A61K36/534A61P31/14A61P11/00A61K2236/333A61K2236/39A61K2236/331A61K2236/53A61K2236/51A61K2300/00Y02A50/30A61K36/185A61K2236/33A61K2236/30
Inventor 肖伟陶晓倩张新庄苏真真柯志鹏曹泽彧曹亮
Owner JIANGSU KANION PHARMA CO LTD
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