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Compositions and methods for the treatment of lung emphysema and other forms of COPD

A treatment method and composition technology, applied in the field of drug therapy

Active Publication Date: 2020-09-01
EMPHYSEMA SOLUTIONS BV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0020] With the exception of lung transplantation, no COPD intervention has been shown to be effective in restoring lung function [1]

Method used

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  • Compositions and methods for the treatment of lung emphysema and other forms of COPD
  • Compositions and methods for the treatment of lung emphysema and other forms of COPD
  • Compositions and methods for the treatment of lung emphysema and other forms of COPD

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Embodiment Construction

[0044] Reactivation of lung elastin fiber production and repair of damaged elastin fibers is necessary to restore lung function. To generate new elastin fibers and repair damaged elastin fibers in adults, three steps are critical: (a) activation of tropoelastin synthesis, (b) activation of tropoelastin assembly into polymer chains, and (c) activation of lysyl oxidase-mediated cross-linking.

[0045] Compositions and methods for treating emphysema and other forms of COPD are provided. These compositions comprise a copper-containing active agent and a glycosaminoglycan or a physiologically acceptable salt thereof.

[0046] The compositions of the present invention are to be used in the treatment of subjects suffering from or at risk of developing emphysema and other forms of COPD with or without airflow limitation. Typically, the subject is a mammal, especially a human, but may be a vertebrate. Airflow limitation is usually both progressive and associated with decreased elast...

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Abstract

A composition for use in a method for the treatment of lung emphysema and other forms of COPD is provided comprising an active agent comprising a copper compound, preferably copper sulfate, and a glycosaminoglycan, preferably heparin, or a physiologically acceptable salt thereof. The composition is preferably administered via inhalation and / or via instillation.

Description

technical field [0001] The present invention belongs to the field of drug therapy. In particular, the present invention relates to compositions and methods for treating emphysema and other forms of chronic obstructive pulmonary disease (COPD) with or without airflow limitation. Background technique [0002] COPD is one of the most prevalent non-communicable diseases. COPD is a complex clinical condition with smoking-related fixed airflow limitation as a common factor, which did not change significantly during the observation period of several months. Furthermore, airflow obstruction shows an unusually rapid progressive deterioration with age. The course of the disease eventually leads to chronic respiratory symptoms. [0003] COPD pathogenesis is characterized by chronic inflammation and accelerated loss of elastic fibers [1] 1 . Chronic airflow limitation in COPD is caused by small airway disease, destruction of the lung parenchyma (ie, emphysema), or a combination of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/30A61K31/726A61K31/727A61K31/728A61P11/00A61P11/08
CPCA61K31/30A61K31/726A61K31/727A61K31/728A61P11/00A61P11/08A61K2300/00A61K45/00A61K31/203A61K9/007A61K31/506A61K33/06A61K31/122A61K33/34
Inventor 罗伯·詹森
Owner EMPHYSEMA SOLUTIONS BV