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Application of Naqu 4580 probiotics in food for improving sleep quality

A technology to improve sleep quality and probiotic preparations, applied in the field of microbiology, can solve problems such as residual effects, tolerance, addiction, etc.

Active Publication Date: 2020-09-11
河北一然生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Long-term use of drugs can easily cause adverse reactions such as addiction, tolerance, and residual effects

Method used

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  • Application of Naqu 4580 probiotics in food for improving sleep quality
  • Application of Naqu 4580 probiotics in food for improving sleep quality
  • Application of Naqu 4580 probiotics in food for improving sleep quality

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0025] Preparation of oral liquid preparations:

[0026] a. Mixing: add conventional culture medium or milk base into the chemical tank, then add sodium glutamate 10-30g / L, dissolve and stir for 10-15min, and keep the temperature of the feed liquid at 55-60°C; the conventional medium is MRS Culture medium;

[0027] b. Sterilization: After sterilizing the feed liquid, put it into the fermenter, pasteurize it at 95-115°C for 15-20 minutes;

[0028] c. Fermentation: Inoculate Nagqu4580 starter (provided by Hebei Yiran Biotechnology Co., Ltd.) into the feed liquid treated in step b for fermentation, the fermentation temperature is 37-45°C, and the fermentation temperature is 28-35h;

[0029] d. When the pH value of the fermentation is 4.0-4.6, stir in the fermentation tank to obtain the Naqu 4580 probiotic fermentation liquid, and then obtain the oral liquid preparation with or without high-temperature sterilization;

[0030] Or sterilize the fermented liquid obtained in step d ...

Embodiment 1

[0044] a. Mixing: Add MRS medium into the chemical tank, then add 10g / L of sodium glutamate, dissolve and stir for 10 minutes, and keep the temperature of the material at 60°C;

[0045] b. Sterilization: After sterilizing the feed liquid, put it into the fermenter, pasteurize it at 105°C for 20 minutes;

[0046] c. Fermentation: Inoculate Nagqu4580 starter (provided by Hebei Yiran Biotechnology Co., Ltd.) into the feed liquid treated in step b for fermentation, the fermentation temperature is 45°C, and the fermentation temperature is 28h;

[0047] d. When the pH value of the fermentation is 4.6, stir in the fermentation tank to obtain the Naqu 4580 probiotic fermentation liquid;

[0048] e. Cryogenic granulation (add the Nagqu 4580 probiotic fermentation broth dropwise into liquid nitrogen in step d, and instantly cool down to -193°C), freeze-dry (vacuum freeze-dry, freeze-drying temperature at -20°C), to obtain Nagqu4580 Probiotic preparations.

[0049] Improvement effect of ...

Embodiment 3

[0063] Embodiment 3 takes Nagqu4580 probiotic preparation to the improvement effect of sleep quality Pittsburg Sleep Quality Index (PSQI) questionnaire statistical result

[0064] The Pittsburgh Sleep Quality Index (PSQI) reflects the sleep quality, sleep time, sleep time, sleep efficiency, sleep disorders, hypnotic drugs, daytime dysfunction and other indicators in the last month. Scoring scale: 0-5 points: good sleep quality; 5-10 points: fair sleep quality; 11-15 points: average sleep quality; 16-21 points: poor sleep quality. The result is as Figure 4 shown.

[0065] Depend on Figure 4 It can be seen that the PSQI index of the youth group decreased by 42.19% after taking it for one week, and 57.27% in the second week compared with before taking it; the PSQI index of the middle-aged group decreased by 32.96% after taking it for one week, The PSQI index decreased by 46.96% compared with before taking; the PSQI index of the elderly group decreased by 39.37% after taking ...

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Abstract

The invention discloses an application of Naqu 4580 probiotics in a food for improving the sleep quality, and belongs to the technical field of microorganisms. The sleep conditions of people of different age groups are obviously improved within two weeks after taking of the Naqu 4580, and along with the prolonging of the time of taking the Naqu 4580, the improvement effect is more obvious and theimprovement rate is 93% or above; and the number of effective days of taking is intensively 3-4, and the symptoms are more obviously improved, namely, the sleeping latency is shortened, the sleeping time is prolonged, and the symptom of awakening at midnight is improved.

Description

technical field [0001] The invention belongs to the technical field of microorganisms, and relates to the application of Naqu 4580 probiotics in food for improving sleep quality. Naqu 4580 probiotics have good acid resistance and can grow well under the environmental conditions of PH3.0; they can produce high levels of γ-aminobutyric acid, serotonin, acetic acid, malic acid, citric acid and tartaric acid, all of which are beneficial to sleep It has obvious efficacy in anti-fatigue. Background technique [0002] Sleep is an important part of people's daily life. With the acceleration of the pace of social life, various social pressures such as buying a house and employment, various forms of sleep quality problems such as sleep disorders and insomnia have also gradually emerged among the crowd. The tendency to spread. [0003] Poor sleep quality is a risk factor for many diseases, and is closely related to high blood pressure, coronary heart disease, diabetes, etc. At the sa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/135
CPCA23L33/135A23V2002/00A23V2400/147A23V2400/165A23V2400/249A23V2200/322
Inventor 赵林森孙策杨玲李玲贾洪利仵红岩宋晓青崔文静
Owner 河北一然生物科技股份有限公司
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