Liquid surgical dressing containing icodextrin

An icodextrin and liquid dressing technology, applied in the field of medical devices, can solve the problems of weak protective effect, small molecular weight, and inability to protect the film, etc., and achieve the effects of preventing scar proliferation, reducing scars, and preventing infection

Active Publication Date: 2020-09-11
HUAREN PHARMACEUTICAL CO LTD +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the molecular weight of α-glucan oligosaccharides is small, so it cannot ...

Method used

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  • Liquid surgical dressing containing icodextrin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Each 10kg icodextrin dressing contains: icodextrin 0.3kg, purified water 9.2kg, 1,3-butanediol 0.4kg, hydrolyzed sclerotin gum 0.05kg, phenoxyethanol 0.02kg, and methyl paraben 0.03 kg.

[0028] The preparation process of the dressing is as follows: icodextrin, hydrolyzed sclerotin gum, methyl paraben, and 1,3-butanediol are dissolved in purified water and heated to 85°C, stirred evenly, kept warm for 30 minutes and then cooled to below 45°C , Add phenoxyethanol. The liquid dressing of Ecodextrin is obtained after standing and defoaming.

Embodiment 2

[0030] Each 10kg icodextrin dressing contains: icodextrin 0.37kg, purified water 9.0kg, 1,2-pentanediol 0.2kg, 1,3-propanediol 0.3kg, polyethylene glycol-115M 0.06kg, phenoxy 0.05 kg of ethanol and 0.02 kg of methyl paraben.

[0031] The preparation process of the dressing is as follows: Dissolve 1,2-pentanediol and 1,3-propanediol in purified water, add icodextrin, polyethylene glycol-115M, stir well, heat to 36.5℃ and add phenoxyethanol , Methyl paraben, stir evenly, leave it to stand for defoaming, and obtain an icodextrin dressing (essence).

Embodiment 3

[0033] Each 10kg icodextrin dressing contains: icodextrin 0.25kg, purified water 9.4kg, 1,2-propanediol 0.1kg, dipropylene glycol 0.1kg, acryloyldimethyl taurine ammonium / VP copolymer 0.05 kg, DMDM ​​hydantoin 0.1kg.

[0034] The preparation process of the dressing is as follows: Dissolve 1,2-propylene glycol and dipropylene glycol in purified water, add icodextrin, ammonium acryloyldimethyl taurate / VP copolymer, stir well, and heat to 35°C Add DMDM ​​hydantoin, stir evenly, and leave it to stand for defoaming to obtain an icodextrin liquid dressing.

[0035] Implementation Effect:

[0036] (1) After high temperature sterilization of the dressings obtained in the above examples, they were all sealed and allowed to stand for one week at normal temperature and pressure, and the state of the auxiliary materials was observed every 6 hours. The obtained dressings were in stable state without flocculation or agglomeration.

[0037] (2) Take 18 rats, apply or spray the dressing obtained in ...

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Abstract

The invention provides a liquid surgical dressing containing icodextrin. Purified water or water used for injection is taken as a carrier, and the icodextrin, polyhydric alcohols, preservatives and thickening agents are added and can be made into a form of mist spray or essence. The liquid surgical dressing disclosed by the invention is high in safety and biocompatibility, can be used for moisturizing and repairing the skin and also can be directly used on a wound or a scar, a skin protection barrier is formed, the wound is accelerated to recover, and scar pigment deposition is alleviated.

Description

Technical field [0001] The invention belongs to the field of medical devices, and specifically relates to a liquid dressing containing icodextrin. Background technique [0002] In the medical field, dressings generally refer to external materials that have the functions of protecting wounds, preventing second-degree infections and heat loss. At present, there are traditional gauze dressings and modern dressings. Modern dressings include sodium alginate / calcium dressings, interactive dressings, and silver Ion dressing, foam dressing and gel dressing, etc. [0003] Glucan is a homopolysaccharide composed of glucose as a monosaccharide, which is divided into α-glucan and β-glucan, and each glucan is divided into multiple bond combinations. As an active ingredient in skin care products, dextran has a long history in the West. Many families in European and American countries are accustomed to bathing infants and young children with oatmeal water to relieve and prevent eczema; the elde...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0023A61L26/0061A61L26/0076C08L3/02
Inventor 杨效东冯新光班文溥王盈盈
Owner HUAREN PHARMACEUTICAL CO LTD
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