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Application of fibroblast growth factor 6 in medicine for relieving non-alcoholic steatohepatitis liver injury

A steatohepatitis, non-alcoholic technology, applied in the field of medicine and biology, to achieve the effect of reducing expression

Active Publication Date: 2020-09-29
SHANGHAI PUDONG NEW AREA PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, there is no report on the relationship between FGF6 and NASH.

Method used

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  • Application of fibroblast growth factor 6 in medicine for relieving non-alcoholic steatohepatitis liver injury
  • Application of fibroblast growth factor 6 in medicine for relieving non-alcoholic steatohepatitis liver injury
  • Application of fibroblast growth factor 6 in medicine for relieving non-alcoholic steatohepatitis liver injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] 1. Construct a high-fat diet (Highfatdiet, HFD)-induced non-alcoholic steatohepatitis (NASH) mouse model (abbreviation: NASH mouse model): refer to relevant literature (ImajoK, FujitaK, YonedaM, et al. mediatedsignaling.CellMetab.2012;16(1):44-54), C57BL / 6J mice were stimulated with low-dose LPS after long-term high-fat diet to simulate NASH-related liver injury. Mice were purchased from Shanghai Slack Experimental Animal Co., Ltd.

[0032] Specifically, 20 healthy male 8-week-old C57BL6 mice were selected, given a 12-week long-term high-fat diet, and then given intraperitoneal injection of LPS (0.25 mg / kg), once a day, for 4 weeks to establish a NASH mouse model. Two weeks after LPS injection, NASH mice were established. LPS was purchased from Sigma-aldrich, USA, item number: L2630-100MG.

[0033] The mRNA sequence of the mouse FGF6 gene: bases 1-44 are the 5'-untranslated region, bases 45-671 are the amino acid coding region; bases 672-1232 are the 3'-untranslated r...

experiment example 1

[0038] Experimental Example 1: Therapeutic effect of FGF6 within the effective dose range on a mouse model of non-alcoholic steatohepatitis induced by a high-fat diet.

[0039] 1. Experimental method:

[0040] (1) Select 20 healthy male 8-week-old C57BL6 mice, and randomly divide them into two groups, 10 mice in each group, and give them intraperitoneal injection of PBS reagent (control solvent) or FGF6 injection (1 mg / kg), once a day (morning 10 o'clock injection).

[0041] (2) 20 NASH mice were selected and randomly divided into two groups, 10 in each group, and were given intraperitoneal injection of PBS reagent (control solvent) or FGF6 injection (1 mg / kg), once a day (injection at 10 am).

[0042] The details of animal grouping and drug administration are shown in Table 1:

[0043] Table 1: Animal grouping and drug administration

[0044] group Number of animals (only) dose Dosing cycle (days) Healthy PBS Group 10 Same volume of control solvent ...

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Abstract

The invention relates to an application of a fibroblast growth factor. The fibroblast growth factor is a fibroblast growth factor 6, and the application is an application in a medicine for relieving non-alcoholic steatohepatitis liver injury. The application has the following advantages: after acting, the fibroblast growth factor 6 has no obvious toxic effect, and can effectively relieve the NASHliver injury; inflammatory cell aggregation and collagen fiber deposition can be effectively relieved; macrophage activation can be effectively inhibited; and the expression of inflammatory factors inthe liver can be effectively reduced.

Description

technical field [0001] The invention relates to the field of medicine and biology, in particular to the application of fibroblast growth factor 6 in medicine for alleviating liver damage caused by non-alcoholic steatohepatitis. Background technique [0002] With the improvement of living standards and changes in lifestyle, the prevalence of non-alcoholic fatty liver disease (Non-alcoholic Fatty Liver disease, NAFLD) is increasing year by year, and has become the most important non-infectious liver disease in the world. Globally, the prevalence of NAFLD is approximately 25%, being highest in the Middle East and South America and lowest in Africa. In the United States, the number of NAFLD cases is projected to increase from 83.1 million (25% of the population) in 2015 to 100.9 million in 2030. In North America and Europe, NAFLD is often associated with central obesity (approximately 83%), whereas in Asia, a significant proportion of "lean NASH" patients occurs despite a norma...

Claims

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Application Information

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IPC IPC(8): A61K38/18A61P1/16
CPCA61K38/1825A61P1/16
Inventor 万健
Owner SHANGHAI PUDONG NEW AREA PEOPLES HOSPITAL
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