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Application of Indian kalimeris herb cold and wind chill compound recipe to preparation of medicines for resisting infection with novel coronaviruses

A coronavirus and compound preparation technology, applied in antiviral agents, drug combinations, pharmaceutical formulas, etc., can solve the problem of no new coronavirus infection

Active Publication Date: 2020-10-16
THE KEY LAB OF CHEM FOR NATURAL PROD OF GUIZHOU PROVINCE & CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But as of now, there is no specific drug for novel coronavirus infection

Method used

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  • Application of Indian kalimeris herb cold and wind chill compound recipe to preparation of medicines for resisting infection with novel coronaviruses
  • Application of Indian kalimeris herb cold and wind chill compound recipe to preparation of medicines for resisting infection with novel coronaviruses
  • Application of Indian kalimeris herb cold and wind chill compound recipe to preparation of medicines for resisting infection with novel coronaviruses

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1: Application of Malan Ganhan Capsules:

[0020] Malan Ganhan Capsules can be purchased from the market, or according to the "National Compilation of Chinese Patent Medicine Standards" Internal Medicine Pulmonary System (1) Volume 156 or "Chinese Pharmacopoeia" 2005 Edition Part 289 or "National Chinese Patent Medicine Standard Compilation" Internal Medicine The preparation method of "Malan Ganhan Capsules" on page 97 of the Qixue Body Fluid Volume, the obtained capsules can be directly used for the prevention / treatment of novel coronavirus infectious diseases. Dosage: Take orally, 5 capsules / time, 3 times / day.

Embodiment 2

[0021] Embodiment 2: the application of Malan cold compound preparation:

[0022] Weigh 186g of Malancao, 6g of Chlorophytum, 146g of iron chopsticks, 116g of blue cloth, 93g of Yunshipi, 116g of perilla leaves and 116g of Nepeta, crush the Malan grass into fine powder, mix Malan with iron chopsticks, blue cloth, Add water and decoct the six flavors of Yunshipi, perilla leaves and Nepeta twice, combine the filtrates, concentrate to a clear paste with a relative density of 1.25-1.28 at 60°C, add Malan grass fine powder, mix well, dry, and then use the existing Various oral preparations are made by preparation molding process. The obtained Malan cold oral preparation can be used for the prevention / treatment of novel coronavirus infectious diseases. Usage and dosage: Oral, 1.5g / time, 3 times / day.

Embodiment 3

[0023] Embodiment 3: the application of Malan cold compound preparation:

[0024] Weigh 186g of Malancao, 6g of Chlorophytum, 146g of iron chopsticks, 116g of blue cloth, 93g of Yunshipi, 116g of perilla leaves and 116g of Schizonepeta, and make various oral preparations by using conventional extraction technology and preparation molding technology. The obtained Malan cold oral preparation can be used to prevent / treat novel coronavirus infectious diseases. Dosage: Oral 1.5g / time, 3 times / day.

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Abstract

The invention discloses an application of an Indian kalimeris herb cold and wind chill compound recipe preparation to preparation of medicines for preventing and treating infection with novel coronaviruses. The Indian kalimeris herb cold and wind chill compound recipe preparation is prepared from raw material medicines of Indian kalimeris herbs, fewflower lysionotus herbs, wintersweet roots or stems, aleppo avens, mysorethorn bark, perilla leaves and fineleaf schizonepeta herbs. Through constructing a medicine screening model for blocking spike glycoprotein of novel coronaviruses and target cell receptor angiotensin converting enzymes 2 (ACE2), the inventor finds that the Indian kalimeris herb cold and wind chill compound recipe preparation has the activity of restraining the combination of the spike glycoprotein of the novel coronaviruses and the target cell receptor ACE2 and expression of type II transmembrane serine protease (TMPRSS2) to prevent viruses from entering target cells, can notably restrain virus-infected cells from generating inflammatory factors (IL-2,IL-6 and the like), can be used for preventing and treating novel coronavirus infectious diseases, provides a medication selection for patients suffering from corona virus disease 2019, and has important effects and significance in prevention and control of current epidemic situations.

Description

technical field [0001] The present invention relates to a new use of medicine, specifically the application of Malan Ganhan compound preparation in the preparation of medicines for preventing / treating novel coronavirus infection, which belongs to the technical field of traditional Chinese medicine application. Background technique [0002] Malan Ganhan is a national medicine formula preparation, Miao medicine: relieve the exterior and dispel cold, clear the lungs and relieve cough; it is used to treat headaches, aversion to cold and fever, runny nose and cough due to anemofrigid cold. The main raw material components include Malan grass, iron chopsticks, spider plant and other medicinal materials. [0003] Coronaviruses are enveloped, single-stranded positive-sense RNA viruses that are widely found in human, mammalian, and avian hosts and can cause respiratory, intestinal, hepatic, and neurological diseases. There are six kinds of coronaviruses known to humans, four of whic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/73A61K9/48A61P31/14A61P11/00
CPCA61K36/28A61K36/185A61K36/73A61K36/48A61K36/535A61K36/538A61K9/48A61P31/14A61P11/00A61K2236/331A61K2236/39A61K2236/51A61K2300/00
Inventor 李艳梅杨小生宋晶睿杨礼寿饶青邱剑飞杨珏
Owner THE KEY LAB OF CHEM FOR NATURAL PROD OF GUIZHOU PROVINCE & CHINESE ACADEMY OF SCI
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