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Aqueous extract of anti-inflammatory traditional Chinese medicine compound, pharmaceutical composition and application

A technology of water extract and composition, applied in the field of water extract of anti-inflammatory traditional Chinese medicine compound, can solve the problems of increasing the difficulty of diagnosis and treatment of chronic prostatitis and evaluating the curative effect, complicated etiology, unclear pathogenesis of chronic prostatitis, etc.

Inactive Publication Date: 2020-10-23
NORTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Since the pathogenesis of chronic prostatitis is still unclear, and its etiology is complex, it is more difficult to diagnose, treat and evaluate the curative effect of chronic prostatitis

Method used

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  • Aqueous extract of anti-inflammatory traditional Chinese medicine compound, pharmaceutical composition and application
  • Aqueous extract of anti-inflammatory traditional Chinese medicine compound, pharmaceutical composition and application
  • Aqueous extract of anti-inflammatory traditional Chinese medicine compound, pharmaceutical composition and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (1) Soak the anti-inflammatory Chinese medicine compound in 75% ethanol with a volume fraction of 7-9 times its volume overnight, and decoct the obtained soaking solution for the first time for 1.4-1.6 hours; the anti-inflammatory Chinese medicine compound includes the following formulas: Each component in parts by mass: 15 parts by mass of Taurus VII, 10 parts by mass of Cinnabar VII, 15 parts by mass of Sedum Panax notoginseng;

[0025] (2) Add the soaking liquid after the first decoction to 75% ethanol with a volume fraction of 6 times its volume, and then decoct for the second time for 1 hour;

[0026] (3) The solution obtained after the second decoction was filtered and evaporated under low pressure to obtain an extract, and the extract was dehydrated at 60° C. to obtain a powdery water extract 1 .

Embodiment 2

[0028] (1) Soak the anti-inflammatory Chinese medicine compound in 75% ethanol with a volume fraction of 7 times its volume overnight, and decoct the resulting soaking solution for 1.4 hours for the first time; the anti-inflammatory Chinese medicine compound includes the following parts by mass: Each component is calculated: 5 parts by mass of Taurus seven, 5 parts by mass of cinnabar seven, 25 parts by mass of Sedum notoginseng;

[0029] (2) Add the soaking solution after the first decoction to 75% ethanol with a volume fraction of 5 times its volume, and then decoct for the second time for 0.9h;

[0030] (3) The solution obtained after the second decoction was filtered and evaporated under low pressure to obtain an extract, and the extract was dehydrated at 58° C. to obtain a powdery water extract 2 .

Embodiment 3

[0032] (1) Soak the anti-inflammatory Chinese medicine compound in 75% ethanol with a volume fraction of 9 times its volume overnight, and decoct the resulting soaking solution for 1.6 hours for the first time; the anti-inflammatory Chinese medicine compound includes the following parts by mass: Each component is calculated: 25 parts by mass of Taurus seven, 25 parts by mass of cinnabar seven, 5 parts by mass of sedum notoginseng;

[0033] (2) Add the soaking solution after the first decoction to 75% ethanol with a volume fraction of 7 times its volume, and then decoct for the second time for 1.1 h;

[0034] (3) The solution obtained after the second decoction was filtered and evaporated under low pressure to obtain an extract, and the extract was dehydrated at 62° C. to obtain a powdery water extract 3 .

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Abstract

The invention discloses an aqueous extract of an anti-inflammatory traditional Chinese medicine compound, a pharmaceutical composition and application. The anti-inflammatory traditional Chinese medicine compound comprises the following components in parts by weight: 5 to 25 parts of radix stephaniae tetrandrae, 5 to 25 parts of cinnabar root and 5 to 25 parts of aizoon stonecrop herb. The preparation method comprises the following steps: soaking materials of the anti-inflammatory traditional Chinese medicine compound in 75% ethanol of which the volume is 7-9 times that of the materials overnight, and decocting obtained soak solution for the first time; adding the soak solution after first decoction into 75% ethanol of which the volume is 5-7 times that of the soak solution, and then carrying out second decoction; and filtering the solution obtained after second decoction, carrying out low-pressure evaporation to obtain an extract, and dehydrating the extract at the temperature of 58-62DEG C to obtain the powdery aqueous extract. The aqueous extract and pharmaceutically acceptable diluents, carriers, derivatives or excipients form the pharmaceutical composition, and the aqueous extract and the pharmaceutical composition can be used as anti-inflammatory drugs for chronic prostatitis. The aqueous extract disclosed by the invention is simple to prepare, and the aqueous extract andthe pharmaceutical composition disclosed by the invention have good anti-inflammatory effect.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a water extract of anti-inflammatory traditional Chinese medicine compound, its preparation method, its pharmaceutical composition and its application. Background technique [0002] Chronic prostatitis is a clinical syndrome caused by different etiologies that occurs in young and middle-aged men. Due to the complex physiological structure and pathological anatomy of the prostate itself, the disease is difficult to cure, and there is a lack of effective and reasonable treatment methods. Its clinical manifestations are mainly discomfort and pain in the lumbosacral, lower abdomen or prostate area, decreased sexual function, and abnormal urination symptoms. , The curative effect is poor. At present, it is believed that the cause of the disease may be related to unclean sex life, irregular rhythm, urine reflux, excessive drinking, and long-term sexual...

Claims

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Application Information

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IPC IPC(8): A61K36/714A61K36/8945A61P13/08A61P29/00
CPCA61K36/714A61K36/704A61K36/41A61K36/8945A61P13/08A61P29/00A61K2236/333A61K2236/39A61K2300/00
Inventor 王永华杨瑞杰黄超郭子湖陈学通郑春丽
Owner NORTHWEST UNIV
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