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Light-regulated virus propagation system and construction method and application thereof

A technology of reproduction system and light regulation, which is applied in the field of using light to regulate virus reproduction system and construction, and can solve the problems of undiscovered patent publications and the like

Pending Publication Date: 2020-10-30
TIANJIN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Through the search, no patent publications related to the patent application of the present invention have been found

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  • Light-regulated virus propagation system and construction method and application thereof
  • Light-regulated virus propagation system and construction method and application thereof
  • Light-regulated virus propagation system and construction method and application thereof

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Embodiment Construction

[0047] The embodiments of the present invention are described in detail below. It should be noted that the embodiments are narrative and not restrictive, and the protection scope of the present invention cannot be limited by this.

[0048] The raw materials used in the present invention are conventional commercial products unless otherwise specified; the methods used in the present invention, unless otherwise specified, are conventional methods in the field.

[0049] A light-regulated virus reproduction system, which includes a light source and a light-sensitive NSP9 degradation system:

[0050] The light source can emit blue light, and the light source can adjust the light time, light intensity, and light frequency required by the light control virus reproduction system;

[0051] The light-sensitive NSP9 degradation system includes the light-sensitive protein vhhNB-Fc and the E3 ubiquitin ligase TRIM21.

[0052] Moreover, the mechanism of action of the system is that the respiratory di...

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Abstract

The invention relates to a light-regulated virus propagation system, which comprises a light source and a light-sensitive NSP9 degradation system, wherein the light source can emit blue light, and thelight source can adjust the illumination time, the illumination intensity and the illumination frequency required by the light-regulated virus propagation system; the light-sensitive NSP9 degradationsystem comprises a light-sensitive protein vhhNB-Fc and an E3 ubiquitin ligase TRIM21. According to the system, degradation of key protein NSP9 for virus proliferation can be regulated and controlledby adjusting the illumination condition, so that PRRSV propagation is regulated and controlled, and the system is simple, efficient and convenient to operate.

Description

Technical field [0001] The invention belongs to the field of biotechnology, and particularly relates to a light-regulated virus reproduction system and a construction method and application. Background technique [0002] Porcine Reproductive and Respiratory Disorder Syndrome is mainly caused by Porcine Reproductive and Respiratory Disorder Syndrome Virus (PRRSV), which causes huge economic losses every year and is an important pathogen affecting the pig industry worldwide. PRRSV can invade the immune system through a variety of ways, including regulating IL-10, inhibiting the function of macrophages and dendritic cells, and inhibiting the production of type I interferons (IFN-α / β), leading to persistent viral infections. Therefore, studying the mechanism of virus infection and effectively controlling PRRSV infection has become an urgent need for current research. PRRSV is a single-stranded positive-stranded RNA virus, belonging to the Arteritis virus family Arteritis virus. It h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/42C12N13/00C12N7/00C12N15/62C12N15/85C12N5/10
CPCC12M21/02C12N13/00C12N7/00C07K14/00C12N5/0686C12N5/0603C12N2510/02C12N2770/10051C07K2319/00
Inventor 王汉杰郝亚锋常津周恩民杜涛峰
Owner TIANJIN UNIV
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