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Metformin chitosan microcapsule/starch composite film and preparation method thereof

A technology of chitosan microcapsule and starch composite film, which is applied in the field of biomedicine, can solve the problems of poor microcapsule encapsulation rate, lack of temperature sensitivity or pH sensitivity, poor water solubility of chitosan, etc., and achieve enhanced stability and solidification Better effect, not easy to swell

Active Publication Date: 2016-03-16
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, in terms of practical application, due to the poor water solubility of chitosan, it can only be dissolved in dilute acid, and cannot form a water phase with high uniformity with water-soluble drugs, resulting in poor encapsulation efficiency of the prepared microcapsules. low drug loading
Moreover, the chitosan slow-release wall material has a single-layer film structure, and its molecular skeleton is loose. It is easy to swell in a slow-release environment, so that the drug is released in a large amount in the early stage, and the burst release phenomenon is particularly serious; another common problem is Yes, due to the lack of temperature-sensitive or pH-sensitive groups in the chitosan structure, the drug loaded in its microcapsules can only be released slowly over time, not controlled release
Such problems limit the clinical application and development prospects of chitosan microcapsules in the field of biomedical technology

Method used

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  • Metformin chitosan microcapsule/starch composite film and preparation method thereof
  • Metformin chitosan microcapsule/starch composite film and preparation method thereof
  • Metformin chitosan microcapsule/starch composite film and preparation method thereof

Examples

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Effect test

Embodiment 1

[0034] A kind of preparation method of biguanide chitosan microcapsule / starch composite film, comprises the following steps:

[0035](1) Preparation of biguanide microcapsules: Weigh 0.30 g of water-soluble drug and dissolve in 30 mL of biguanide chitosan-acetic acid solution with a concentration of 0.01 g / mL and stir to form a uniform aqueous phase; take 10 mL of Span 80 and Tween 20 and add into the 90mL solution mixed with petroleum ether and liquid paraffin at a volume ratio of 1:1 and stirred until uniform to obtain an oil phase; under shear stirring at a speed of 900rpm, add the water phase drop by drop to the oil phase, and add The time is 15min, and emulsified for 15min; 20mL glutaraldehyde is added dropwise for solidification, the dropping time is 1h, and the solidification time is 1h; washing with acetone, and drying in an oven at 40°C to obtain drug-loaded microcapsules with a particle size of 1-10 μm and an encapsulation efficiency of 85.70%.

[0036] (2) Composit...

Embodiment 2

[0042] (1) The difference between step (1) in this example and step (1) in Example 1 is that the addition of water-soluble drug is adjusted to 0.20 g, and the addition of glutaraldehyde is adjusted to 20 mL. Other steps and parameters were the same as step (1) in Example 1, and the encapsulation efficiency of the prepared drug-loaded microcapsules was 72.66%.

[0043] (2) With step (2) in embodiment 1.

Embodiment 3

[0045] (1) With step (1) in embodiment 2.

[0046] (2) The difference between step (2) in this example and step (2) in Example 1 is that the addition of agar powder is adjusted to 0.25 g, and the addition of drug-loaded microcapsules is adjusted to 0.010 g. Other steps and parameter are identical with step (1) in embodiment 1, and the composite film tensile strength that is prepared is 8.11Mpa, elongation at break is 80.36%, the biguanide chitosan microcapsule that drug-loaded microcapsule content is 1% / starch composite film.

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Abstract

The invention belongs to the technical field of biological medicine, and particularly relates to a metformin chitosan microcapsule / starch composite film and a preparation method thereof. Metformin chitosan, starch and an agar powder natural polysaccharide molecule material serve as the base materials, medicine-carrying metformin chitosan microcapsules with granularity of 1-10 microns are prepared first through an emulsion cross-linking method, amino groups (from metformin groups) and hydroxyl groups enriched on surfaces of microcapsules are utilized and fixed into mesh-shaped structures in the form of hydrogen bonds in the gelatinization stage, and then the metformin chitosan microcapsule / starch composite film is prepared, wherein the mesh-shaped structure is formed by mixing starch molecule chains and agar in a phase-uniform mode. The interior structure of the metformin chitosan microcapsule / starch composite film is mainly fixed by hydrogen bonds between molecules, and therefore the hydrogen bond stability and ion effect can be effectively weakened or enhanced by adjusting the pH value in a low-release system, the swelling and degrading degree of the composite film is controlled, and the slow-release effect of the medicine is controlled.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a biguanide chitosan microcapsule / starch composite film and a preparation method thereof. Background technique [0002] The drug controlled release system is to use polymer materials to enter the organism through oral or implantation methods, and release the drug in the organism in a specific long period of time according to a predetermined release rate, so as to achieve long-term treatment. Purpose. Compared with the conventional drug administration mode, the advantages of drug controlled release are: (1) It can maintain the drug concentration in the body within the effective therapeutic range for a long time, and will not be too high or too low, reducing its toxic and side effects; (2) Improve the drug concentration. Bioavailability; (3) Targeted delivery of drugs can improve therapeutic pertinence; (4) Facilitate the administration of drugs with short half-liv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/5383A61K47/36
CPCA61K9/0002A61K9/50A61K9/7007A61K31/5383A61K47/36
Inventor 周晓华王维霍炜强谢淦澂
Owner SOUTH CHINA AGRI UNIV
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