Micro-droplet electrospray device and method capable of screening quinoxaline derivative synthesis conditions at high throughput

Abstract

The invention discloses a micro-droplet electrospray device and method capable of screening quinoxaline derivative synthesis conditions at high throughput. The micro-droplet electrospray device comprises an injector, a sample introduction capillary tube, a T-shaped micro tee joint and a metal electrospray needle TaperTips which are connected in sequence. A vertical inlet of the T-shaped micro teejoint is connected with a nitrogen auxiliary gas capillary tube; and the end part of the metal electric spray needle TaperTips is provided with a tip, and the metal electric spray needle TaperTips isconnected with a high-voltage direct-current power supply. By using the tee joint component, a reaction solution and nitrogen auxiliary gas are combined, and under the action of voltage, a better spraying effect is achieved, and spraying liquid drops with smaller sizes are formed, so that the reaction efficiency of reaction is greatly improved, and finally, the signal peak of a reaction product can be more directly and conveniently detected through mass spectrometry. The reactor realizes integration of synthesis and detection of quinoxaline derivatives, and the operation method is simple and easy.

Description

technical field [0001] The invention belongs to the technical field of analysis and detection, and relates to a micro-droplet electrospray device and method capable of high-throughput screening of synthesis conditions of quinoxaline derivatives. Background technique [0002] The information in this Background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes prior art that is already known to those skilled in the art. [0003] As one of the most important nitrogen heterocycles, the quinoxaline structure is recognized as the main building block for the synthesis of many biologically active compounds. Quinoxaline derivatives such as levomycin, actinomycin, and echinomycin have high biological activity and are used as therapeutic agents. Furthermore, these compounds are important intermediates for the industrial p...

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Problems solved by technology

According to the research of the inventors, although this method has achieved good yields, there are still some disadvantages in these methods including high reaction temperature, use of toxic / highly costly solvents or catalysts, long reaction time, etc.

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