Application of nervonic acid in preparation of thyroid malignant tumor detection reagent
A malignant tumor and detection reagent technology, applied in the field of pharmaceutical reagents, can solve the problems of lack of specificity, poor positive predictive value, etc., and achieve the effect of improving detection speed and accuracy, expanding the scope of medicinal use and market demand
Pending Publication Date: 2020-11-27
中元伯瑞生物科技(珠海横琴)有限公司
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Disappointingly, all of these biomarkers either lack specificity to some degree or have poor positive predictive value
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specific Embodiment approach 1
[0013] Embodiment 1: Application of nervonic acid in the preparation of a detection reagent for thyroid malignancy in this embodiment: the detection reagent uses nervonic acid as a biomarker for thyroid malignancy.
specific Embodiment approach 2
[0014] Embodiment 2: This embodiment differs from Embodiment 1 in that the nervous acid is SM (d18:2 / 24:1). Others are the same as in the first embodiment.
[0015] In this embodiment, nervonic acid SM (d18:2 / 24:1) belongs to compounds containing nervonic acid chains.
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The invention discloses application of nervonic acid in preparation of a thyroid malignant tumor detection reagent, and relates to the field of pharmaceutical reagents. According to the application, nervonic acid SM (d18: 2 / 24: 1) is used as a biomarker for thyroid malignant tumors in preparation of the detection reagent for thyroid malignant tumors. The invention provides a noninvasive, effectiveand reliable serum marker for identifying benign and malignant thyroid nodules, so that the influence of invasive surgery on the body and mind of a patient is avoided, and meanwhile, the detection speed and accuracy are improved. According to the invention, nervonic acid SM (d18: 2 / 24: 1) is used as a biomarker of thyroid malignant tumors, and the detection of the metabonomics can be carried outthrough blood; secondly, the metabonomics can detect small molecular metabolites, and the possible change of thyroid malignant tumors can be well illustrated; and finally, the clinical mastering of the diagnosis and treatment conditions of diseases can be well guided through the discovery of nervonic acid. The nervonic acid is suitable for being used as a biomarker for thyroid malignant tumors.
Description
technical field [0001] The invention relates to the field of pharmaceutical reagents, in particular to the application of nervonic acid in the preparation of detection reagents for malignant thyroid tumors. Background technique [0002] Thyroid cancer is the most common endocrine malignancy among head and neck malignancies, accounting for 91.5% of all endocrine malignancies, accounting for 1% of all malignant diseases, and showing an increasing trend year by year. Early accurate diagnosis and timely treatment are the key to improve the long-term survival rate of PTC (papillary thyroid carcinoma) patients. There are many diagnostic tools for thyroid cancer, such as ultrasound, computed tomography, magnetic resonance imaging, cytology and fine needle aspiration. At present, ultrasound-guided fine-needle aspiration biopsy is considered to be the most effective examination method for differentiating benign and malignant thyroid nodules, but it is an invasive procedure. Therefo...
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Login to view more IPC IPC(8): G01N30/02G01N30/72G01N33/50
CPCG01N30/02G01N30/72G01N33/50G01N2800/7028
Inventor 陈显扬宋王婷常婷婷
Owner 中元伯瑞生物科技(珠海横琴)有限公司
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