Crystal form and preparation method of a kind of oxopyridine amide derivative

Abstract

The invention relates to a crystal form and a preparation method of oxopyridine amide derivatives. Specifically, the present invention relates to crystal forms A, B, C, D, E, and F of the compound of formula (I) and a preparation method thereof. The crystal form of the compound of formula (I) of the present invention has good crystal stability and can be better used in clinic.

Description

[0001] This application claims the priority of the Chinese patent application CN201810710037.1 with the filing date of July 2, 2018. This application cites the full text of the above-mentioned Chinese patent application. technical field [0002] The invention belongs to the field of medicinal chemistry, and relates to a blood coagulation XIa inhibitor (S)-4-(4-(tert-butoxy)-2-(4-(5-chloro-2-propionylphenyl)-5- A crystal form of methoxy-2-oxopyridin-1(2H)-yl)butyrylamino)benzoic acid and a preparation method thereof. Background technique [0003] Cardiovascular and cerebrovascular diseases such as cerebrovascular, cerebral infarction, myocardial infarction, coronary heart disease, and arteriosclerosis kill nearly 12 million people every year in the world, which is close to 1 / 4 of the total death toll in the world. In China, more than 2.6 million people die from cardiovascular diseases every year, and 75% of the surviving patients are disabled, and more than 40% of them are s...

AI Technical Summary

Problems solved by technology

Generally speaking, amorphous pharmaceutical products have no regular crystal structure and often have other defects, such as poor product stability, fine crystallization, difficult filtration, easy agglomeration, poor fluidity, etc.

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