A salt of heteroarylo[4,3-c]pyrimidin-5-amine derivatives, crystal form of the salt and preparation method thereof

Abstract

The invention relates to a salt of a heteroarylo[4,3-c]pyrimidine-5-amine derivative, a crystal form of the salt and a preparation method. Specifically, the present invention relates to a salt of a compound of formula I, a crystal form of the salt and a preparation method. The crystal form of the salt of the compound of formula I in the present invention has good crystal stability and can be better used clinically.

Description

technical field [0001] The invention belongs to the field of medicinal chemistry and relates to 8-(2-(difluoromethyl)-6-methylpyridin-4-yl)-7-(2,4-difluorophenyl)-[1,2,4 A salt of triazolo[4,3-c]pyrimidin-5-amine, a crystal form of the salt and a preparation method thereof. Background technique [0002] Adenosine is a naturally occurring purine nucleoside that is an endogenous regulator of many physiological functions. It plays an important role in the regulation of cardiovascular system, central nervous system, respiratory system, kidney, fat and platelet function. [0003] The action of adenosine is mediated by the G protein-coupled receptor family. Currently, there are at least four subtypes of adenosine receptors, classified as A1, A2a, A2b, and A3. Among them, the A1 and A3 receptors inhibit the activity of the enzyme adenylate cyclase, while the A2a and A2b receptors stimulate the activity of this enzyme, thereby regulating the level of cyclic AMP in cells. Through t...

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Problems solved by technology

Generally speaking, amorphous pharmaceutical products have no regular crystal structure and often have other defects, such as poor product stability, fine crystallization, difficult filtration, easy agglomeration, poor fluidity, etc.

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