Crystal form and preparation method of a kind of 1,2,4-triazine-3-amine derivative

Abstract

The invention relates to a crystal form and a preparation method of a 1,2,4-triazine-3-amine derivative. Specifically, it relates to A, B, C, D, E, F, G, H, J crystal forms of the compound of formula (1) and a preparation method thereof. The crystal form of the compound of formula (1) has good crystal stability and can be better used clinically. (I)

Description

[0001] This application claims the priority of Chinese patent application CN201810767419.8 with an application date of July 13, 2018. This application cites the full text of the above Chinese patent application. technical field [0002] The invention belongs to the field of medicinal chemistry, and relates to A, B, C, D, E, F, G, H, J crystal forms and preparation methods. Background technique [0003] Adenosine is a naturally occurring purine nucleoside that is an endogenous regulator of many physiological functions. It plays an important role in the functional regulation of the cardiovascular system, central nervous system, respiratory system, kidneys, fat and platelets. [0004] The action of adenosine is mediated by a family of G protein-coupled receptors, and at least four subtypes of adenosine receptors are known, classified as A 1 , A 2a , A 2b and A 3 . where A 1 and A 3 The receptor inhibits the activity of the enzyme adenylyl cyclase, while A 2a and A 2b...

AI Technical Summary

Problems solved by technology

Generally speaking, amorphous pharmaceutical products have no regular crystal structure and often have other defects, such as poor product stability, fine crystallization, difficult filtration, easy agglomeration, poor fluidity, etc.

Images