Evening primrose essence B-casein phosphopeptide-chitosan nano particle, preparation method and applications thereof
A casein phosphopeptide and chitosan nanoparticle technology, which is applied in the fields of application, hydrolyzed protein components, peptide/protein components, etc., can solve the problem of affecting the formation of evening primrose B-casein phosphopeptide-chitosan nanoparticles , not clear and other issues, to achieve significant loading effect, stable characterization parameters, and high drug loading effect
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[0049] Example 1
[0050] 1. The preparation method of evening primrose B-casein phosphopeptide-chitosan nanoparticles, the specific steps are as follows:
[0051] (1) Material selection: CPPs with a purity of 90% (w / w) are polyanionic materials, CS with a degree of deacetylation of 90% or more and a molecular weight of 130kDa is polycationic materials, and OEB has a purity of 90% (w / w) or more The purity of genipin is 98% (w / w).
[0052] (2) Prepare a certain concentration of CPPs solution, CS solution and OEB solution respectively, and adjust the pH of the three solutions to 2.00 and the NaCl concentration of 1 mol / L. In addition, 0.5% (v / v) acetic acid solution was used to assist the dissolution of CS, and 1 mol / L HCl was used to adjust the pH of the three solutions.
[0053] (3) Mix the CPPs solution and the OEB solution evenly, and then add them dropwise to the CS solution under stirring. The mass fractions of CPPs, CS and OEB in the final solution are 43%, 43% and 14% respectiv...
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[0079] Example 2
[0080] A preparation method of evening primrose B-casein phosphopeptide-chitosan nanoparticles, the specific steps are as follows:
[0081] (1) Material selection: CPPs with a purity of 90% (w / w) are polyanionic materials, the degree of deacetylation is above 90%, the degree of deacetylation is above 90%, and the molecular weight is 130kDa CS is a polycationic material, and OEB has a purity of 90 %(W / w) and above, the purity of genipin is 98%(w / w).
[0082] (2) Prepare a certain concentration of CPPs solution, CS solution and OEB solution respectively, and adjust the pH of the three solutions to 2.00, and the NaCl concentration is 1mol / L. In addition, 0.5% (v / v) acetic acid solution was used to assist the dissolution of CS, and 1 mol / L HCl was used to adjust the pH of the three solutions.
[0083] (3) Mix the CPPs solution and the OEB solution evenly, and then add them dropwise to the CS solution under stirring. The mass fractions of CPPs, CS and OEB in the final s...
Example Embodiment
[0088] Example 3
[0089] A preparation method of evening primrose B-casein phosphopeptide-chitosan nanoparticles, the specific steps are as follows:
[0090] (1) Material selection: CPPs with a purity of 90% (w / w) are polyanionic materials, CS with a degree of deacetylation of 90% or more and a molecular weight of 44~500kDa is polycationic materials, and OEB has a purity of 90% (w / w). ) Above, the purity of genipin is 98% (w / w).
[0091] (2) Prepare a certain concentration of CPPs solution, CS solution and OEB solution respectively, and adjust the pH value of the solution to 2.00, and the concentration of NaCl is 1mol / L. In addition, 0.5% (v / v) acetic acid solution was used to assist the dissolution of CS, and 1 mol / L HCl was used to adjust the pH of the three solutions.
[0092] (3) Mix the CPPs solution and the OEB solution uniformly, and then add them dropwise to the CS solution under stirring. The mass fractions of CPPs, CS and OEB in the final solution are 40%, 40% and 20% resp...
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