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Compositions comprising such fruit extracts

A technology for water-soluble extracts and compositions, which can be applied in drug combinations, food ingredients containing natural extracts, food ingredients containing inorganic compounds, etc., and can solve the problem of not inhibiting the activation of the blood coagulation system.

Active Publication Date: 2020-12-11
PROVEXIS NATURAL PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, such antiplatelet agents do not inhibit exercise-induced activation of the coagulation system

Method used

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  • Compositions comprising such fruit extracts
  • Compositions comprising such fruit extracts
  • Compositions comprising such fruit extracts

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0142] Water-soluble extract having activity of inhibiting platelet aggregation tomato prepared by the following scheme:

Embodiment 2

[0146] Example 2 provides a preferred method for preparing a composition according to the third aspect of the present invention, the composition comprises a water soluble tomato extract, a combination of a nitrate source and a dietary source of folic acid.

[0147] 2.1 soluble tomato extract should be obtained as outlined in Example 1 and prepared as described. At a concentration of 430μg / ml of the extract solution by extract embodiment will be described in Example 1.1 was diluted, or by the example 1.2 in the powdered extract prepared by dissolving in deionized water. The resulting 430μg / ml solution buffered to pH 7.4 for the experimental scheme used in the experimental program further ten-fold dilutions to give a final working concentration of 43μg / ml of. This concentration represents the most preferred unit dosage ingestion (3g liquid extract (1.1), 150 mg of powder extract (1.2)) for about 3 hours, the maximum plasma concentration calculation cycle antiplatelet compound ...

Embodiment 3

[0153]According to this study, it is unexpectedly confirmed that the water-soluble tomato extract is adjusted to adjust the three biological systems, which is affected by vigorous exercise, and represents the different inflammation responses caused by strenuous exercise. aspect. These three biological systems are: platelet-known part of the coagulation system that is strongly activated due to motion-induced thrombin and adrenaline release into blood and the exhaustion of circulating nitric oxide; stem from circulating plasma cells Microparticles, which are platelets and white blood cell activation and inflammation; and endothelial cytokines release, especially cytokines IL-6, which are one of the best markers for fertile inflammation. It can be considered that vigorous motion induces a chain reaction that causes systemic inflammation, which is released by platelet activation and platelet-white blood cell microparticles, and then due to exposure to activated blood cells and the par...

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Abstract

The present invention relates to the use of a fruit extract and optionally other specific nutrients for preventing, reducing or minimising exercise-induced systemic inflammation and / or for promoting recovery from intense exercise. The invention also relates to compositions comprising such fruit extracts.

Description

[0001] This application is a divisional application No. Chinese patent application 201380067642.7, the original application is a PCT International Application PCT 2013 Nian 12, filed May 24 in / GB2013 / 053431 application into the national phase of China on June 23, 2015. Technical field [0002] The present invention relates to compositions comprising fruit extracts, or combinations of other specific nutrients and optionally fruit extracts, which are useful for preventing exercise-induced systemic inflammation and promote recovery from strenuous exercise. Background technique [0003] Keeping any exercise program needs to ensure both mental and physical. [0004] The extent depends on the sustained strength (in the absence of sustained injury) resilience to the movement of the body pressure applied thereto scheme, namely, to recover from the impact of these pressures in speed. [0005] Recovery from exercise involved in many body processes. These procedures include repairing dam...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/81A61P29/00A61P21/00A61P7/02A23L33/105A23L2/02A23L2/52A23L33/15A23L33/175A61K31/519
CPCA61K31/525A23V2200/33A23L33/105A23L33/15A23L33/16A23V2002/00A61K31/519A61K36/81A61P21/00A61P29/00A61P3/02A61P43/00A61P7/02A61K2300/00A23V2200/30A23V2200/316A23V2250/15A23V2250/21A23V2250/7056A61K36/21A61K9/0053A61K9/009A61K9/06A61K9/20
Inventor 尼亚夫·奥肯尼迪
Owner PROVEXIS NATURAL PROD
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