Preparation method of cold granules

Abstract

The invention discloses a preparation method of cold granules. The preparation method includes the following steps: sieving sucrose powder and acetaminophen premix powder and adding the sieved powderinto a mixing groove to perform dry mixing; weighing an extract and storing the extract in an extract bucket; pouring caffeine and chlorpheniramine maleate into a beaker, adding boiled water to dissolve and then pouring the mixture into the extract bucket, cleaning the beaker with the boiled water and pouring the solution into the extract bucket, and stirring the extract; after stirring, adding the extract into a groove type mixer while stirring, cleaning the extract bucket with 500 ml of purified water after the extract is added, and adding the cleaning water into the groove type mixer; observing the description of the wet-mixed soft material, and adding ethanol to adjust color; pelleting with a pelleting mesh, shaping granules for 2-3 min in a tray after pelleting, and drying by suckingthe granules into a drying machine; and performing granulation. The preparation method is simple and low in cost; and the prepared granules are firm, high in uniformity, uniform in drug loading, largein drug loading capacity and controllable.

Description

technical field [0001] The invention relates to the technical field of preparation of granules, in particular to a method for preparing cold granules. Background technique [0002] The traditional preparation method of traditional Chinese medicine or herbal medicine granules is to make traditional Chinese medicine or herbal medicine or its extracts into granular substances with a certain particle size by dry method or wet method, and drink or swallow them with water when used by patients. Due to the high viscosity of traditional Chinese medicine or herbal medicine extracts, most of the traditional granule preparation methods have problems such as low drug loading, unsightly appearance, poor particle uniformity, and lack of firmness. Therefore propose a kind of new cold granule preparation method Contents of the invention [0003] The technical problem to be solved by the present invention is to overcome the above technical defects and provide a preparation method of cold ...

AI Technical Summary

Problems solved by technology

Due to the high viscosity of traditional Chinese medicine or herbal medicine extracts, most of the traditional granule preparation methods have problems such as low drug loading, unsightly appearance, poor particle uniformity, and inconsistency.