An electrospinning nanofiber membrane loaded with self-assembled traditional Chinese medicine component vesicles and its preparation method and application

A nanofiber membrane and electrospinning technology, applied in the field of pharmaceutical preparations, can solve the problems that dispersible tablets cannot effectively protect the wound surface, cannot guarantee safety, increase the difficulty of treatment, etc., achieve excellent biological properties, and improve drug bioavailability. , the effect of improving bioavailability

Active Publication Date: 2022-07-19
LIAONING UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, dispersible tablets cannot effectively protect the wound surface, and additional treatment methods need to be added, which increases the difficulty of treatment
Gel preparations are prone to wound infection due to their poor air permeability
Solvents such as formic acid and acetic acid are highly corrosive, easy to damage needles and difficult to remove during industrial production, increasing production costs and safety cannot be guaranteed

Method used

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  • An electrospinning nanofiber membrane loaded with self-assembled traditional Chinese medicine component vesicles and its preparation method and application
  • An electrospinning nanofiber membrane loaded with self-assembled traditional Chinese medicine component vesicles and its preparation method and application
  • An electrospinning nanofiber membrane loaded with self-assembled traditional Chinese medicine component vesicles and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] An electrospinning nanofiber membrane loaded with self-assembled traditional Chinese medicine component vesicles, the preparation method comprising the following steps:

[0044] 1. In the dark, slowly add polycaprolactone (PCL) and phospholipid (PC) into the mixed solvent, and stir in a closed place in the dark until completely dissolved, then continue to stir for 3 hours, and finally remove the bubbles by ultrasonic, and the obtained mixed solution is used as a spinning solution. Shell solution of silk material.

[0045] Mixed solvent preparation: dichloromethane (CH 2 CL 2 ) and N-N dimethylformamide (DMF) in a volume ratio of 5:1, stirring and mixing evenly to obtain a mixed solvent.

[0046] In the obtained shell solution, the concentration of polycaprolactone (PCL) was 30% (w / v%) and the concentration of phospholipid (PC) was 4% (w / v%) by mass volume percentage.

[0047] 2. Add polyvinylpyrrolidone (PVP) and centella asiatica total glycosides (CTG) into absolute...

Embodiment 2

[0053] An electrospinning nanofiber membrane loaded with self-assembled traditional Chinese medicine component vesicles, the preparation method comprising the following steps:

[0054] 1. In the dark, slowly add polycaprolactone (PCL) and phospholipid (PC) into the mixed solvent, and stir in a closed place in the dark until completely dissolved, then continue to stir for 3 hours, and finally remove the bubbles by ultrasonic, and the obtained mixed solution is used as a spinning solution. Shell solution of silk material.

[0055] Mixed solvent preparation: dichloromethane (CH 2 CL 2 ) and N-N dimethylformamide (DMF) in a volume ratio of 5:1, stirring and mixing evenly to obtain a mixed solvent.

[0056] In the obtained shell solution, the concentration of polycaprolactone (PCL) was 30% (w / v%) and the concentration of phospholipid (PC) was 8% (w / v%) by mass volume percentage.

[0057] 2. Add polyvinylpyrrolidone (PVP) and centella asiatica total glycosides (CTG) into absolute...

Embodiment 3

[0063] An electrospinning nanofiber membrane loaded with self-assembled traditional Chinese medicine component vesicles, the preparation method comprising the following steps:

[0064] 1. In the dark, slowly add polycaprolactone (PCL) and phospholipid (PC) into the mixed solvent, and stir in a closed place in the dark until completely dissolved, then continue to stir for 3 hours, and finally remove the bubbles by ultrasonic, and the obtained mixed solution is used as a spinning solution. Shell solution of silk material.

[0065] Mixed solvent preparation: dichloromethane (CH 2 CL 2 ) and N-N dimethylformamide (DMF) in a volume ratio of 5:1, stirring and mixing evenly to obtain a mixed solvent.

[0066] In the obtained shell layer solution, the concentration of polycaprolactone is 30% (w / v%) and the concentration of phospholipid (PC) is 8% (w / v%) by mass volume percentage.

[0067] 2. Add polyvinylpyrrolidone (PVP) and centella asiatica total glycosides (CTG) into absolute e...

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Abstract

The invention discloses an electrospinning nanofiber membrane loaded with self-assembled traditional Chinese medicine component vesicles, and a preparation method and application thereof. Through the electrospinning technology, the water-soluble polymer material and the total glucosides of Centella asiatica are spun into the core layer, and the water-insoluble polymer material and the phospholipid are spun into the shell layer to form an electrospinning nanofiber membrane with a core-shell structure. In the early stage of trauma, the water-soluble material absorbs tissue exudate to expose the API, and the phospholipids encapsulate the free drug to form a vesicle structure to promote drug absorption, which ultimately promotes the formation of vascular endothelial cells and collagen fibers, and accelerates wound healing. The invention creatively applies research hotspots in the field of materials to a drug preparation delivery system, the prepared electrospinning nanofiber membrane is used for tissue regeneration and repair, and animal experiments achieve good results. The invention makes up for the defect that the existing trauma field relies on traditional treatment methods, provides a basis for the existing industrial production, and also provides a new choice for clinicians and patients to treat.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to an electrospinning nanofiber membrane loaded with self-assembled vesicles of traditional Chinese medicine ingredients and a preparation method and application thereof. Background technique [0002] As the largest and most external organ of the human body, the skin is extremely vulnerable to trauma. Various acute and chronic traumas have plagued people for thousands of years. Therefore, it has always been a research hotspot in the medical field. Patients often suffer from shock or even death due to loss of body fluids and infection. [0003] At present, skin wounds are mainly divided into acute wounds and burns. In the case of natural wound healing without intervention, scars are often left, leaving patients with huge psychological barriers. The main basis for the treatment of wounds at this stage is to accelerate the wound Healing, reducing or inhibiting sca...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/26A61L15/20A61L15/24A61L15/44A61L15/62D04H1/4382D04H1/728
CPCA61L15/26A61L15/24A61L15/20A61L15/62A61L15/44D04H1/728D04H1/43828D10B2509/022A61L2300/232A61L2300/412A61L2400/12C08L67/04C08L39/06
Inventor 潘昊段宏亮于双陆飞妃陈立江
Owner LIAONING UNIVERSITY
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