Preparation and application in pharmacy field of silica medical microsphere

Abstract

A silica microsphere is prepared by melting or grinding high purity silica; the silica microsphere is purified then to reach the requirements of pharmaceutical adjuvant and has good roughness and mechanical strength; the particle size is in a range of 40 to 250 [mu]m, and the bulk density is in a range of 1.2 to 1.6 g/cm3. The silica medical microsphere can be applied to the pharmacy field, is taken as a blank pill core for wuster coating, can be used to coat particles with a size smaller than 150 [mu]m, can cover the odor, and is capable of achieving the sustained-release and control-release functions. Based on the proper particle size distribution, high bulk density and mechanical strength, and good roughness, the yield of coated particles with a size smaller than 150 [mu]m is largely increased, and the coating yield is more than 90%.

Description

technical field [0001] The invention relates to a silicon dioxide pharmaceutical microsphere, their preparation and pharmaceutical purification method, and the application of the silicon dioxide pharmaceutical microsphere in the field of particle coating preparations smaller than 150 μm. Background technique [0002] Medicinal blank cores are the necessary mother cores for the production of micropill preparations. At present, the commonly used blank cores for micropill preparations mainly include: sugar pills (sucrose type), microcrystalline cellulose pellet cores, starch pellet cores, and lactose pellet cores. , silica ball cores, etc., which are mainly used for drug application and coating of pellets. The particle size range is 300-800 μm, and different types of ball cores have different stability, bulk density, and friability, so they cannot be applied to pellets smaller than For the coating of 150μm granules, the existing blank cores (≤150μm) have many defects when using...

AI Technical Summary

Problems solved by technology

[0002] Medicinal blank cores are the necessary mother cores for the production of micropill preparations. At present, the commonly used blank cores for micropill preparations mainly include: sugar pills (sucrose type), microcrystalline cellulose pellet cores, starch pellet cores, and lactose pellet cores. , silica ball cores, etc., which are mainly used for drug application and coating of pellets. The particle size range is 300-800 μm, and different types of ball cores have different stability, bulk density, and friability, so they cannot be applied to pellets smaller than For the coating of 150μm granules, the existing blank cores (≤150μm) have many defects when using wuster coating technology, because the existing blank cores (≤150μm) have small particle size and large specific surface area. Moreover, there are irregularities and inhomogeneities in the granules themselves, the coating is difficult, the weight of the coating is large, the breakage rate is high, and the product yield is very low. Some blank cores cannot be realized at all, and the coating granules also have inhomogeneity. Satisfactory results cannot be achieved when applied to taste-masking and sustained-release preparations, such as uneven taste-masking, uneven release, or even burst release or broken

This greatly limits the application of wuster coating technology in the pharmaceutical field of particles smaller than 150 μm

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