A traditional Chinese medicine composition for treating oral mucosal damage caused by antineoplastic drugs

An anti-tumor drug and oral mucosal technology, applied in drug combination, drug delivery, pharmaceutical formulation, etc., can solve the problems of low-quality recommendations, lack of high-quality research, life-threatening problems, etc., to heal oral mucosal damage, improve quality of life, Safe to use

Active Publication Date: 2021-11-19
浙江省中医院、浙江中医药大学附属第一医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although the above methods can slightly relieve oral mucosal injury, there is still a lack of sufficient clinical data to support the effectiveness of the treatment of oral mucosal injury, and no drugs have been approved for the treatment of radiation-induced oral mucositis at home and abroad, mostly based on expert consensus , some recommendations are still in the low-to-medium quality and weak recommendation research stage, and there is a lack of high-quality research
Our clinical experience also shows that the efficacy of the above methods is not ideal
What is even more worrying is that oral mucosal damage not only affects the patient's psychology and quality of life, but also has a higher risk of developing into systemic infection or even sepsis, which is life-threatening in severe cases
Such patients can only suspend the treatment because they cannot continue to tolerate the original dose of anti-tumor treatment
Even after the drug is stopped, the oral mucosal injury still takes half a month to one month or even several months to subside. When the patient recovers and receives reduction therapy again, the risk of severe oral mucosal injury is still high, and the dose reduction or even drug withdrawal is adopted. Undoubtedly, the measures weaken the treatment intensity, affect the progress of anti-tumor treatment, and threaten the long-term survival of patients.
[0006] In general, domestic and foreign treatment methods for oral mucosal injury caused by anti-tumor drugs have limited clinical efficacy and lack of high-level evidence support. Some studies did not consider the intensity of anti-tumor treatment and ignored the overall survival of patients.

Method used

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  • A traditional Chinese medicine composition for treating oral mucosal damage caused by antineoplastic drugs
  • A traditional Chinese medicine composition for treating oral mucosal damage caused by antineoplastic drugs
  • A traditional Chinese medicine composition for treating oral mucosal damage caused by antineoplastic drugs

Examples

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Effect test

Embodiment 1

[0030] Prescription: Cimicifuga 12g, Baiji 15g, honeysuckle 15g, wood butterfly 8g, Scrophulariaceae 15g, cicada slough 5g, angelica 10g, licorice 9g.

[0031] Preparation method: take the raw material according to the proportion, add 10 times the quality of water, decoct twice, filter to get the filtrate, concentrate, filter, and pack into 100ml / bottle.

[0032] Usage: Pour 20ml of liquid medicine into the mouth each time, rinse for 5 minutes, 3 times a day.

Embodiment 2

[0034] Prescription: Cimicifuga 15 parts by weight, Baiji 20 parts by weight, honeysuckle 20 parts by weight, wood butterfly 9 parts by weight, Scrophulariaceae 20 parts by weight, cicada slough 6 parts by weight, angelica 15 parts by weight, licorice 12 parts by weight.

[0035] Preparation method: Take the raw material drug in proportion, extract twice with 50% ethanol under reflux, combine the extracts, filter, recover ethanol, add water to dissolve, concentrate under reduced pressure to a density of 1.10 (60°C), centrifuge at high speed, take the supernatant, add conventional Excipients, made into external preparations, put into sterile spray containers.

[0036] Usage: Spray directly on the damaged oral mucosa, 2 sprays each time, 3 times a day.

Embodiment 3

[0038] Prescription: Cimicifuga 9g, Baiji 10g, honeysuckle 10g, wood butterfly 6g, Scrophulariaceae 9g, cicada slough 3g, angelica 6g, licorice 5g.

[0039] Preparation method: with the preparation method of embodiment 1.

[0040] Usage: Pour 20ml of liquid medicine into the mouth each time, rinse for 5 minutes, 3 times a day.

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Abstract

The invention provides a traditional Chinese medicine composition for treating oral mucosal damage caused by antineoplastic drugs, which comprises the following components in parts by weight: 9-15 parts by weight of Cimicifuga, 10-20 parts by weight of Baiji, 10-20 parts by weight of Flos Lonicerae Parts, wood butterfly 6-9 parts by weight, Scrophulariaceae 9-20 parts by weight, cicada slough 3-6 parts by weight, angelica 6-15 parts by weight, licorice 5-12 parts by weight. The invention can significantly improve and cure oral mucosal damage caused by antitumor drugs in a short period of time, is safe to use, has definite curative effect, and obviously improves the quality of life of patients without reducing the intensity of antitumor treatment.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating oral mucosal damage caused by antineoplastic drugs. Background technique [0002] With the rapid development of precision medicine today, oral mucosal injury is a common complication in cancer patients receiving antineoplastic drugs. In patients with solid tumors, about 40% of patients will develop severe oral mucosal damage after receiving conventional doses of antineoplastic drugs. For patients with hematological tumors, they must receive high-dose chemotherapy before hematopoietic stem cell transplantation, and about 90% of patients will suffer from oral mucosal damage. [0003] However, antineoplastic drug-related oral mucosal injury will bring a lot of pain to patients, mainly manifested as varying degrees of inflammatory changes, dryness, sensitivity, ulcers, etc. in the oral mucosa. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/898A61P1/02A61K35/64
CPCA61K9/006A61K35/64A61K36/185A61K36/232A61K36/355A61K36/484A61K36/71A61K36/808A61K36/898A61P1/02A61K2300/00
Inventor 舒琦瑾陈舒怡寿柳梅陈群伟
Owner 浙江省中医院、浙江中医药大学附属第一医院
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