Preparation method of 3',5'-dichloro-2,2,2-trifluoroacetophenone

A technology of trifluoroacetophenone and chlorinating reagent is applied in the field of preparation of 3′,5′-dichloro-2,2,2-trifluoroacetophenone, and can solve the problem of high industrial production cost and high raw material cost , poor economic effect and other problems, to achieve the effects of low equipment maintenance components, lower production costs, and improved economic effects
CN112110803AActive Publication Date: 2020-12-22TAIZHOU ABSOBIOTEC CO LTD +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
TAIZHOU ABSOBIOTEC CO LTD
Publication Date
2020-12-22

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Abstract

The invention relates to the technical field of chemical pharmacy, particularly to a preparation method of 3',5'-dichloro-2,2,2-trifluoroacetophenone. According to the invention, 3',5'-dichloro-2,2,2-trifluoroacetophenone is prepared from 3'-chloro-2,2,2-trifluoroacetophenone as a raw material through four steps of nitrification, reduction, chlorination and deamination, and the method has the advantages of low raw material cost, mild reaction conditions, simple reaction process, facilitation of the reduction of the production cost, and improvement of the economic effect.
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Description

technical field

[0001] The present application relates to the technical field of chemical industry and pharmacy, in particular to a preparation method of 3′,5′-dichloro-2,2,2-trifluoroacetophenone. Background technique

[0002] 3′,5′-Dichloro-2,2,2-trifluoroacetophenone is an important intermediate used in the synthesis of pesticides and veterinary drugs.

[0003] In the prior art, the synthesis methods of 3′,5′-dichloro-2,2,2-trifluoroacetophenone mainly include the following types:

[0004] 1. The PCT patent with the application number WO2018009751 discloses a preparation method using 3,5-dichlorobromobenzene and methyl trifluoroacetate as starting materials, using tetrahydrofuran as a solvent, by adding 3,5-dichlorobromobenzene React with isopropylmagnesium chloride-lithium chloride to prepare Grignard reagent and then react with methyl trifluoroacetate. In the above-mentioned prior art, isopropylmagnesium chloride and tetrahydrofuran are relatively expensive and explosi...

Claims

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