Blood flow imaging apparatus and method based on optical clearing agent

An imaging method and transparent agent technology, which can be used in blood flow measurement, medical science, sensors, etc., can solve the problems of limited application of OCTA, and achieve the effects of long coherent imaging range, improved imaging signal-to-noise ratio, and high signal sensitivity.

Pending Publication Date: 2020-12-25
THE FIRST MEDICAL CENT CHINESE PLA GENERAL HOSPITAL
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Problems solved by technology

[0005] In view of the above analysis, the present invention aims to provide a blood flow imaging device and method based on an optically clear agent to solve the problems of limited application of OCTA in skin in the prior art

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  • Blood flow imaging apparatus and method based on optical clearing agent

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[0037] A device and method for blood flow imaging based on an optical transparent agent will be further described in detail below in conjunction with specific examples. These examples are only for the purpose of comparison and explanation, and the present invention is not limited to these examples.

[0038]The present invention provides a blood flow imaging device based on an optical transparent agent, including a high-speed frequency-sweeping laser light source 1, a first fiber coupler 2, a second fiber coupler 15, a sample detection branch, a reference branch, and a balance detection Device 16 and computer 17; high-speed frequency-sweeping laser light source 1 is divided into two beams of light through the first fiber coupler 2, the first beam of light enters the sample detection branch to generate sample light; the second beam of light enters the reference branch to generate reference light, The sample light and reference light are redistributed and interfered in the second ...

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Abstract

The invention discloses blood flow imaging apparatus and method based on an optical clearing agent, belongs to the technical field of optical coherence tomography, and solves the problem that an application of OCTA in the skin is limited in the prior art. The blood flow imaging apparatus comprises a high-speed sweep-frequency laser light source, a first optical fiber coupler, a second optical fiber coupler, a sample detection branch, a reference branch, a balance detector and a computer, wherein the high-speed sweep-frequency laser light source is divided into two beams of light through the first optical fiber coupler, the first beam of light enters the sample detection branch to generate sample light, the second beam of light enters the reference branch to generate reference light, the sample light and the reference light are redistributed in the second optical fiber coupler and interfere with each other, and a ratio of the first beam of light to the second beam of light, divided by the first optical fiber coupler, of the high-speed sweep-frequency laser light source ranges from 90:10-60:40. The interference light is detected by the balance detector, interference signals are converted into electric signals, and the electric signals are collected by the computer. The blood flow imaging apparatus and method are suitable for skin tissue imaging.

Description

technical field [0001] The invention belongs to the technical field of optical coherence tomography, and in particular relates to a blood flow imaging device and method based on an optical transparent agent. Background technique [0002] OCT is an emerging technology with the characteristics of non-invasiveness and high resolution. Its basic structure is a low-coherence interferometer, which divides the light emitted by the light source into two parts, the reference light and the sample light, and then, the reflected light of the reference arm and the backscattered light of the sample arm detected by the detector The interference signal is then passed through the A / D converter and then imaged by a computer to obtain a 2D / 3D image. [0003] With the continuous maturity of OCT technology, OCT has experienced from time domain OCT (TDOCT) to Fourier domain OCT (FD-OCT), and Fourier domain OCT can also be divided into frequency domain OCT (SDOCT) and frequency sweep OCT ( SS-OC...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/026A61B5/00
CPCA61B5/0066A61B5/0261A61B5/441
Inventor 邱海霞许景江顾瑛袁钘曾晶刘一荻
Owner THE FIRST MEDICAL CENT CHINESE PLA GENERAL HOSPITAL
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