Application of lentinus edodes mycelium polysaccharide in preparing medicine for inhibiting amylase activity
A mycelium polysaccharide, active drug technology, applied in application, drug combination, organic active ingredients and other directions, can solve problems such as unreported, achieve the effects of preventing diabetes, slowing release and absorption, and having great application prospects
Pending Publication Date: 2021-01-01
LIAONING UNIVERSITY
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[0005] At present, the application of Lentinus edodes mycelia polysaccharides in
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[0018]Example 1 Fluorescence spectroscopy to detect the inhibitory effect of Lentinus edodes mycelium polysaccharide on amylase
[0019]Dissolve amylase in 3mL phosphate buffer (0.01mol·L-1,pH 7.4), the final concentration is 1×10-5mol·L-1Solution, and then add 10μL, 20μL, 30μL mother liquor to make 3×10-3mol·L-1Mix the lentinus mycelium polysaccharide solution in the mixed solution so that the concentration of lentinus mycelium polysaccharide in the mixed solution is 1×10-5, 2×10-5, 3×10-5mol·L-1, React 3min at 25℃.
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The invention belongs to the field of medicines or health-care products, and discloses application of lentinus edodes mycelium polysaccharide singly used or used together with other medicines in medicines for inhibiting amylase activity. The lentinus edodes mycelium polysaccharide can be used for reducing postprandial and fasting blood glucose levels by inhibiting the activity of amylase, so thatthe effect of preventing diabetes mellitus is achieved. The lentinus edodes mycelium polysaccharide is derived from lentinus edodes mycelium, can better inhibit amylase activity, and provides theoretical basis and experimental basis for development of health products and medicines for preventing diabetes mellitus, and therefore, the lentinus edodes mycelium polysaccharide provides a new thought for development of hypoglycemic health-care products.
Description
technical field [0001] The invention belongs to the technical field of research and development of medicines or health care products, and relates to the application of mushroom mycelium polysaccharides in medicines for inhibiting amylase activity, especially the application in medicines for preventing diabetes. Background technique [0002] With the improvement of living standards, the number of diabetic patients worldwide is increasing year by year, and it has become one of the chronic diseases that seriously threaten human health. Diabetes is a chronic metabolic syndrome characterized by hyperglycemia and can lead to various types of complications, including neurological diseases, atherosclerosis, retinopathy, and diabetic nephropathy. Amylase is a key enzyme that affects the digestion and absorption of starch and other major carbohydrates in the diet. Inhibiting its activity can delay the degradation of starch and other substances and the absorption of glucose by the huma...
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Login to view more IPC IPC(8): A61K31/715A61K36/07A23L33/125A23L31/00A61P3/10
CPCA61K31/715A61K36/07A61P3/10A23L33/125A23L31/00A23V2002/00A23V2200/328A23V2250/51A23V2250/208
Inventor 曹向宇夏莹程野谢言真唐志鹏梅雪迎丁尉哲
Owner LIAONING UNIVERSITY
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