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Protein film dressing beneficial to wound healing based on cooperation of three bioactive scaffold materials and cytotrophic factors

A scaffold material and cell nutrition technology, which is applied in the application of protein film dressings in the medical field. In the field of protein film dressings, it can solve the problems of allergic inflammation, incapable of large-scale production, and poor quality of wound healing in the later stage, so as to prevent skin oxidation and prevent Pigmentation, fast epithelial repair effect

Active Publication Date: 2021-01-22
杭州伊瑟奇生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Wound dressings have relatively high requirements on the biocompatibility and bioactivity of wound repair materials, and there are not many suitable materials. Many protein film dressings on the market come from a single source. The amino acid signal sequence cannot guarantee the effect, and the process is immature, so it cannot be produced on a large scale
Some dressings on the market even add crude Chinese herbal medicines, which can easily cause allergic inflammation in the early stage, prolong the inflammatory period of the wound, and the healing quality of the wound in the later stage is very poor, and it is easy to cause pigmentation

Method used

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  • Protein film dressing beneficial to wound healing based on cooperation of three bioactive scaffold materials and cytotrophic factors
  • Protein film dressing beneficial to wound healing based on cooperation of three bioactive scaffold materials and cytotrophic factors
  • Protein film dressing beneficial to wound healing based on cooperation of three bioactive scaffold materials and cytotrophic factors

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A protein film dressing based on three bioactive scaffold materials synergistically with cytotrophic factors to help wound healing. It consists of the following components in terms of mass percentage: 15% keratin, 50% oxidized keratin, and 0.05% schizophyllin powder %, pluripotent stem cell conditioned culture supernatant 10%, chlorella extract 1%, glycerol glucoside 5%, chitosan powder 0.05%, leuconostococcus / radish root fermentation product filtrate 1%, glycerol 2 %, water 15.9%.

[0032] Patient 1 has a medical history of more than 20 years, the wound on the arm has not healed, the affected area is red and swollen, the epidermis is damaged, and there is occasional exudation; using the protein film dressing prepared in this embodiment, after one month of treatment, the effect is as follows: figure 1 As shown, it can be seen that the wound has scabbed over.

Embodiment 2

[0034] A protein film dressing based on three kinds of bioactive scaffold materials synergistically with cytotrophic factors to help wound healing, which consists of the following components in terms of mass percentage: keratin 50%, oxidized keratin 10%, schizophyllin powder 1 %, pluripotent stem cell conditioned culture supernatant 6%, chlorella extract 5%, glycerol glucoside 10%, chitosan powder 0.2%, leuconostococcus / radish root fermentation product filtrate 5%, glycerol 3 %, water 9.8%.

[0035] Patient 2 had multiple skin lesions on the back, showing redness and swelling. According to dictation, sometimes accompanied by itching, the wound has never healed for 20 years; the protein film dressing prepared in this example was used after one month of treatment. Such as figure 2 As shown, the wound has completely healed, with slight redness, and the skin can repair itself.

Embodiment 3

[0037] A protein film dressing based on three bioactive scaffold materials synergistically with cytotrophic factors to help wound healing. It consists of the following components in terms of mass percentage: 20% keratin, 30% oxidized keratin, and 0.2% schizophyllin powder %, pluripotent stem cell conditioned culture supernatant 1%, chlorella extract 25%, glycerol glucoside 2%, chitosan powder 0.8%, leuconostococcus / radish root fermentation product filtrate 3%, glycerol 4 %, water 14%.

[0038] The wound on the hand of patient 3 is a chronic wound and has not healed for 3 years; the effect of using the protein film dressing prepared in this example after 2 days is as follows: image 3 As shown, it can be clearly seen that after 2 days of treatment, the skin is still a little red, but it is no longer red and swollen, and the wound has healed.

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Abstract

The present invention provides a protein film dressing beneficial to wound healing based on cooperation of three bioactive scaffold materials and cytotrophic factors. The protein film dressing comprises the following ingredients: keratin, oxidized keratin, schizophyllan powder, a pluripotent stem cell condition culture supernatant, a chlorella extract, glucosylglycerol, deacetylated chitosan powder, a leuconostoc / radish root fermentation product filtrate, glycerol and water. The provided protein film dressing is rich in functional important physiological structural proteins and biological polysaccharides, and various nutritional factors and growth factor groups required by cells, and closer to a protein source of human body, does not generate immunological rejection, facilitates rapid recovery of acute wounds, can rapidly coagulate blood, stop seepage and resist inflammation, can enable an inflammation stage to be converted to a repair stage for chronic wounds, and prevents skin oxidation and pigmentation caused by free radicals.

Description

technical field [0001] The invention relates to the field of biological products, in particular to a protein film dressing based on three bioactive scaffold materials and cell trophic factors to help wound healing and the application of the protein film dressing in the medical field. Background technique [0002] An in-depth understanding of the pathophysiological mechanism of wound healing can improve the level of wound care, and the exploration and optimization of materials hope to bring more efficient wound care solutions. Wound healing is one of the most complex processes in multicellular organisms, involving numerous signaling within and between a variety of cells. Physical, chemical, and cytokines are involved in biological processes with wound repair as the main goal. The healing mechanisms of skin wounds can be divided into repair and regeneration, with clear and important distinctions between the two types of healing. The characteristics and characteristics of the...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0066A61L26/0047A61L26/0023A61L26/0057A61L2300/412A61L2300/214A61L2300/30A61L2300/414A61L2300/41A61L2300/418
Inventor 朱国君罗晓丹
Owner 杭州伊瑟奇生物科技有限公司
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