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Method for preparing D-pantoic acid through continuous catalysis

A technology for catalytic preparation of pantoic acid, applied in the field of continuous catalytic preparation of D-pantoic acid, to achieve high production efficiency, low energy consumption, and simple post-treatment

Pending Publication Date: 2021-03-12
HEFEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to provide a method for continuously catalyzing the preparation of D-pantoic acid, which can improve the production efficiency of D-pantoic acid, reduce production costs, and solve the problem of odor at the production site

Method used

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  • Method for preparing D-pantoic acid through continuous catalysis

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Effect test

Embodiment 1

[0027] Such as figure 1 Shown, the present invention provides a kind of method of continuous catalytic preparation D-pantoic acid, comprises the following steps:

[0028] S1. Put the immobilized enzyme into a set of resin columns 6 connected in series, and a storage tank 7 is connected between two adjacent resin columns, wash with deionized water until the effluent turns from light black to yellow, and finally becomes colorless Stop washing when the washing time is over, the washing flow rate is controlled to 0.3Bv / h, loosen after washing, and stand by;

[0029] S2. Add 350kg DL-pantoate lactone (reduced pure) and deionized water to the 1500L dissolving and decolorizing kettle 1, stir evenly, control the temperature at 30±2°C, and use phosphate buffer solution to adjust the DL-pantoate lactone The pH of the ester solution is 7.5;

[0030] S3. Add 7kg of 767 medicinal activated carbon and 3.5kg of polyaluminum chloride to the dissolving and decolorizing kettle 1, decolorize a...

Embodiment 2

[0036] Such as figure 1 Shown, the present invention provides a kind of method of continuous catalytic preparation D-pantoic acid, comprises the following steps:

[0037] S1. Put the immobilized enzyme into a set of resin columns 6 connected in series, and a storage tank 7 is connected between two adjacent resin columns, wash with deionized water until the effluent turns from light black to yellow, and finally becomes colorless Stop washing when the washing time is over, the washing flow rate is controlled to 0.3Bv / h, loosen after washing, and stand by;

[0038] S2. Add 350kg DL-pantoate lactone (reduced pure) and deionized water to the 1500L dissolving and decolorizing kettle 1, stir evenly, control the temperature at 30±2°C, and use phosphate buffer solution to adjust the DL-pantoate lactone The pH value of the ester solution is 7.0;

[0039] S3. Add 7kg of 767 medicinal activated carbon and 3.5kg of polyaluminum chloride to the dissolving and decolorizing kettle 1, decolo...

Embodiment 3

[0045] Such as figure 1 Shown, the present invention provides a kind of method of continuous catalytic preparation D-pantoic acid, comprises the following steps:

[0046] S1. Put the immobilized enzyme into a group of resin columns 6 connected in series, and a storage tank 7 is connected between two adjacent resin columns, wash with deionized water until the effluent turns from light black to yellow, and finally becomes colorless Stop washing when the washing time is over, the washing flow rate is controlled to 0.3Bv / h, loosen after washing, and stand by;

[0047] S2. Add 350kg DL-pantoate lactone (reduced pure) and deionized water to the 1500L dissolving and decolorizing kettle 1, stir evenly, control the temperature at 30±2°C, and use phosphate buffer solution to adjust the DL-pantoate lactone The pH of the ester solution is 6.5;

[0048] S3. Add 7kg of 767 medicinal activated carbon and 3.5kg of polyaluminum chloride to the dissolving and decolorizing kettle 1, decolorize a...

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Abstract

The invention discloses a method for preparing D-pantoic acid by continuous catalysis. The method comprises the following steps: filling immobilized enzyme into a group of resin columns connected in series, connecting a storage tank between two adjacent resin columns, and washing with deionized water until the effluent is colorless; dissolving DL-pantolactone in deionized water, and adjusting thepH value of the DL-pantolactone solution to 6.5-7.5 by using a phosphate buffer solution; adding activated carbon and a flocculating agent into the DL-pantolactone solution for de-coloration and flocculation to obtain a de-colorized solution; pumping the de-colorized solution into a resin column, and carrying out an enzymatic hydrolysis reaction to obtain a hydrolysate; pumping the hydrolysate into a nano filtration system, and concentrating to remove water to obtain nano filtration liquid; pumping the nano filtration liquid into a group of extraction columns connected in series, carrying outmulti-stage counter-current extraction, and recycling the extraction liquid; carrying out vacuum concentration on the raffinate to obtain D-pantoic acid; according to the method, the production efficiency of the pantoic acid can be improved, the production cost is reduced, and the problem of odor in a production field is solved.

Description

technical field [0001] The invention relates to the technical field of enzyme engineering, in particular to a method for continuously catalyzing and preparing D-pantoic acid. Background technique [0002] Calcium D-pantothenate is widely used in food, feed and pharmaceutical industries, and has a large market demand. The current production process first synthesizes DL-pantoate lactone with isobutyraldehyde, formaldehyde, and sodium cyanide, and then obtains D-pantoate through chemical resolution or biological enzymatic resolution, and then undergoes a cyclization reaction to generate D-pantolactone, and finally β-alanine calcium and D-pantolactone are condensed to generate D-pantothenate calcium. [0003] In the prior art, the disadvantages of chemical resolution of DL-pantoate lactone are: chemical resolution agents such as quinine compounds and chiral amines are expensive and not conducive to environmental protection; First, D-pantolactone hydrolase selectively hydrolyze...

Claims

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Application Information

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IPC IPC(8): C12P41/00C12P7/42C07C51/42C07C51/47C07C59/105
CPCC12P41/003C12P7/42C07C51/42C07C51/47
Inventor 丁振东张洪斌王珍沈治强宋丁丁刘晨张敬新
Owner HEFEI UNIV OF TECH
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