Compound, traditional Chinese medicine probiotic fermentation product and application thereof to preparation of medicine with anti-atherosclerosis effect
A technology of fermentation products and compounds, applied in the field of biomedicine, can solve the problems of less research on compound fermentation of traditional Chinese medicine, and achieve the effect of enhancing cell damage and apoptosis
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Embodiment 1
[0066] The preparation of embodiment 1 formula (I) compound
[0067] (1) Mix 40 g of traditional Chinese medicine raw materials and 10 g of probiotic dry powder in a three-dimensional mixer until the color is uniform, then add 60 g of water, and ferment for 36 hours at a temperature of 25°C and a pH of 5.4 to obtain a fermentation broth;
[0068] (2) centrifuging the fermentation broth at 8000r / min for 30min, removing the precipitate and retaining the supernatant, and freeze-drying the supernatant to obtain a crude product;
[0069] (3) separating the crude product by chromatographic techniques to obtain the compound of formula (I);
[0070] The traditional Chinese medicine raw material described in the step (1) consists of honey, hawthorn extract, astragalus extract, salvia miltiorrhiza extract, schisandra extract, ginkgo leaf extract and kudzu root extract in a weight ratio of 1:1:1:1:1: 1:1 composition; the probiotic dry powder is composed of Lactobacillus acidophilus dry ...
Embodiment 2
[0075] The preparation of embodiment 2 formula (I) compound
[0076] (1) Mix 400g of traditional Chinese medicine raw materials and 100g of probiotic dry powder in a three-dimensional mixer until the color is uniform, then add 600g of water, and perform ultrasonic extraction for 60min; then ferment for 48h at a temperature of 25°C and a pH of 5.4 to obtain a fermented liquid;
[0077] (2) centrifuging the fermentation broth at 8000r / min for 30min, removing the precipitate and retaining the supernatant, and freeze-drying the supernatant to obtain a crude product;
[0078] (3) separating the crude product by chromatographic techniques to obtain the compound of formula (I);
[0079]The traditional Chinese medicine raw material described in the step (1) is composed of honey, hawthorn, astragalus, salvia miltiorrhiza, schisandra, ginkgo leaf and kudzu root in a weight ratio of 1:1:1:1:1:1:1; the probiotic dry powder is composed of The dry powder of Lactobacillus acidophilus, the ...
Embodiment 3
[0081] The preparation of embodiment 3 traditional Chinese medicine probiotic fermentation product
[0082] (1) Mix 40 g of traditional Chinese medicine raw materials and 10 g of probiotic dry powder in a three-dimensional mixer until the color is uniform, then add 60 g of water, and ferment for 36 hours at a temperature of 25°C and a pH of 5.4 to obtain a fermentation broth;
[0083] (2) centrifuging the fermented liquid at 8000r / min for 30 min, removing the precipitate and retaining the supernatant, and freeze-drying the supernatant to obtain a traditional Chinese medicine probiotic fermentation product;
[0084] The Chinese medicine raw material described in step (1) is by honey, hawthorn extract, astragalus extract, salvia miltiorrhiza extract, schisandra extract, ginkgo leaf extract and kudzu root extract (the described extracts are all conventional medical raw materials, can be obtained by purchasing) by weight ratio 1:1:1:1:1:1:1; the probiotic dry powder is composed of...
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