Compound, traditional Chinese medicine probiotic fermentation product and application thereof to preparation of medicine with anti-atherosclerosis effect

A technology of fermentation products and compounds, applied in the field of biomedicine, can solve the problems of less research on compound fermentation of traditional Chinese medicine, and achieve the effect of enhancing cell damage and apoptosis

Pending Publication Date: 2021-03-19
刘志刚
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there are separate fermented Chinese medicines on the market, and there are also probiotic fermented fruit and vegetable products, but there are few researches on the compound fermentation of Chinese medicines. Therefore, combining the characteristics of fruits, vegetables and Chinese medicines, the development of fermented fruits and vegetables with Chinese medicine functions will not only provide consumers with more choices. , also provides a broad prospect for the deep processing of traditional Chinese medicine, fruit and vegetable raw materials

Method used

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  • Compound, traditional Chinese medicine probiotic fermentation product and application thereof to preparation of medicine with anti-atherosclerosis effect
  • Compound, traditional Chinese medicine probiotic fermentation product and application thereof to preparation of medicine with anti-atherosclerosis effect
  • Compound, traditional Chinese medicine probiotic fermentation product and application thereof to preparation of medicine with anti-atherosclerosis effect

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Effect test

Embodiment 1

[0066] The preparation of embodiment 1 formula (I) compound

[0067] (1) Mix 40 g of traditional Chinese medicine raw materials and 10 g of probiotic dry powder in a three-dimensional mixer until the color is uniform, then add 60 g of water, and ferment for 36 hours at a temperature of 25°C and a pH of 5.4 to obtain a fermentation broth;

[0068] (2) centrifuging the fermentation broth at 8000r / min for 30min, removing the precipitate and retaining the supernatant, and freeze-drying the supernatant to obtain a crude product;

[0069] (3) separating the crude product by chromatographic techniques to obtain the compound of formula (I);

[0070] The traditional Chinese medicine raw material described in the step (1) consists of honey, hawthorn extract, astragalus extract, salvia miltiorrhiza extract, schisandra extract, ginkgo leaf extract and kudzu root extract in a weight ratio of 1:1:1:1:1: 1:1 composition; the probiotic dry powder is composed of Lactobacillus acidophilus dry ...

Embodiment 2

[0075] The preparation of embodiment 2 formula (I) compound

[0076] (1) Mix 400g of traditional Chinese medicine raw materials and 100g of probiotic dry powder in a three-dimensional mixer until the color is uniform, then add 600g of water, and perform ultrasonic extraction for 60min; then ferment for 48h at a temperature of 25°C and a pH of 5.4 to obtain a fermented liquid;

[0077] (2) centrifuging the fermentation broth at 8000r / min for 30min, removing the precipitate and retaining the supernatant, and freeze-drying the supernatant to obtain a crude product;

[0078] (3) separating the crude product by chromatographic techniques to obtain the compound of formula (I);

[0079]The traditional Chinese medicine raw material described in the step (1) is composed of honey, hawthorn, astragalus, salvia miltiorrhiza, schisandra, ginkgo leaf and kudzu root in a weight ratio of 1:1:1:1:1:1:1; the probiotic dry powder is composed of The dry powder of Lactobacillus acidophilus, the ...

Embodiment 3

[0081] The preparation of embodiment 3 traditional Chinese medicine probiotic fermentation product

[0082] (1) Mix 40 g of traditional Chinese medicine raw materials and 10 g of probiotic dry powder in a three-dimensional mixer until the color is uniform, then add 60 g of water, and ferment for 36 hours at a temperature of 25°C and a pH of 5.4 to obtain a fermentation broth;

[0083] (2) centrifuging the fermented liquid at 8000r / min for 30 min, removing the precipitate and retaining the supernatant, and freeze-drying the supernatant to obtain a traditional Chinese medicine probiotic fermentation product;

[0084] The Chinese medicine raw material described in step (1) is by honey, hawthorn extract, astragalus extract, salvia miltiorrhiza extract, schisandra extract, ginkgo leaf extract and kudzu root extract (the described extracts are all conventional medical raw materials, can be obtained by purchasing) by weight ratio 1:1:1:1:1:1:1; the probiotic dry powder is composed of...

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Abstract

The invention relates to the technical field of biomedicine, and particularly discloses a compound, a traditional Chinese medicine probiotic fermentation product and application thereof to preparationof a medicine with an anti-atherosclerosis effect. The compound has a structure shown as a formula (I) in the specification. The traditional Chinese medicine probiotic fermentation product comprisesthe compound as shown in the formula (I) in the specification. A preparation method of the compound comprises the following steps: (1) taking traditional Chinese medicine raw materials, and fermentingthe traditional Chinese medicine raw materials with probiotics to obtain fermentation liquor; and (2) drying the fermentation liquor to obtain the traditional Chinese medicine probiotic fermentationproduct. The compound shown in the formula (I) and the traditional Chinese medicine probiotic fermentation product have an excellent anti-atherosclerosis effect, and can be used for preparing medicines and health care products.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a compound, a traditional Chinese medicine probiotic fermentation product and its application in preparing medicines with anti-atherosclerosis effects. Background technique [0002] Cardiovascular disease is the leading cause of death and disability worldwide. Atherosclerosis is the main culprit in the development of cardiovascular disease and further acute complications, characterized by chronic inflammation, abnormal immune response, and disturbance of key enzymes related to lipid metabolism. Cardiovascular risk factors such as smoking, hypertension, diabetes and obesity have an important impact on the occurrence of atherosclerosis. High plasma concentrations of cholesterol are one of the major risk factors for atherosclerosis. The current treatment of cardiovascular diseases is mainly statins, which can significantly reduce cardiovascular mortality in patients with hyper...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K5/062C12P21/02A23L33/00A61K36/79A61K36/734A61P9/10C12R1/23C12R1/01A61K35/644
CPCC07K5/06026C12P21/02A23L33/00A61K35/644A61K36/734A61K36/481A61K36/537A61K36/79A61K36/57A61K36/16A61K36/488A61P9/10A23V2002/00A23V2400/113A23V2400/529A23V2400/531A23V2200/10A23V2200/06A23V2200/21A23V2200/326A23V2250/511A23V2250/5432A23V2250/5118A23V2250/708A23V2250/712A23V2250/06A23V2250/211A23V2250/302A23V2250/51A23V2250/60A61K2300/00
Inventor 刘志刚刘杰刘晓宇
Owner 刘志刚
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