Preparation method of lycopene composition with anti-aging effect

A technology of lycopene and lycopene oil, which is applied in the field of medicine, can solve problems such as poor stability, achieve good stability, high content of active ingredients, and improve life expectancy and climbing ability

Pending Publication Date: 2021-03-30
NANJING ZHONGKE GRP CORP LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the stability of the lycopene product of this dosage form is relatively poor

Method used

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  • Preparation method of lycopene composition with anti-aging effect
  • Preparation method of lycopene composition with anti-aging effect
  • Preparation method of lycopene composition with anti-aging effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Lycopene oleoresin is mixed with a little absolute ethanol to obtain lycopene oleoresin alcoholate to increase its fluidity. Put the nicotinamide mononucleotide into the fluidized bed granulator, and in the fluidized bed granulator, the lycopene oleoresin alcoholate is atomized through the nozzle and sprayed onto the fluidized bed in the fluidized bed granulator. On the nicotinamide mononucleotide powder in the melted state, make it wet and fully mix, and flow granulate. After granulation, place the prepared granules in a cool and dry place to dry in the shade. The conditions used for spray granulation are as follows: the atomization speed of the nozzle is 100mL / min, the atomized particle size is 10μm, and the sample loading amount of the fluidized bed is 8kg at one time, and flow granulation is performed. The weight ratio of nicotinamide mononucleotide and lycopene oleoresin is 1:1.

Embodiment 2

[0023] Lycopene oleoresin is mixed with a little absolute ethanol to obtain lycopene oleoresin alcoholate to increase its fluidity. Put the nicotinamide mononucleotide into the fluidized bed granulator, and in the fluidized bed granulator, the lycopene oleoresin alcoholate is atomized through the nozzle and sprayed onto the fluidized bed in the fluidized bed granulator. On the nicotinamide mononucleotide powder in the melted state, make it wet and fully mix, and flow granulate. After granulation, place the prepared granules in a cool and dry place to dry in the shade. The conditions used for spray granulation are as follows: the atomization speed of the nozzle is 40mL / min, the atomized particle size is 12μm, and the sample loading amount of the fluidized bed is 10kg at one time, and flow granulation is performed. The weight ratio of nicotinamide mononucleotide and lycopene oleoresin is 1:2.

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Abstract

The invention discloses a preparation method of a lycopene-containing composition with an anti-aging effect, which comprises the following steps: mixing lycopene oleoresin with a small amount of absolute ethyl alcohol to obtain lycopene oleoresin alcoholate, putting the nicotinamide mononucleotide into a fluidized bed granulator, atomizing the lycopene oleoresin alcoholate by a nozzle through compressed air, spraying the lycopene oleoresin alcoholate onto nicotinamide mononucleotide powder in a fluidized state on the fluidized bed layer, wetting and fully mixing the lycopene oleoresin alcoholate and the nicotinamide mononucleotide powder, and performing flow granulation, wherein the conditions for spray granulation are as follows: the atomizing speed of a nozzle is 40-100mL / min, and the atomizing particle size is 10-12 [mu]m. The anti-aging composition prepared by the method disclosed by the invention can effectively prolong the service life of the drosophila melanogaster, improve theclimbing capacity of the drosophila melanogaster, effectively improve the MDA level of rat serum and the SOD activity of the rat serum, and has a remarkable anti-aging effect. Moreover, the granular product is high in content of effective components and good in stability.

Description

technical field [0001] The invention belongs to the technical field of medicines, and relates to a preparation method of a lycopene composition with anti-aging effect. Background technique [0002] It is generally believed that aging is an irreversible process. With age, various organs of the body, including the immune system, will experience aging phenomenon, and immune aging will be secondary to a variety of age-related diseases, such as tumors, cardiovascular diseases, Alzheimer's disease and osteoporosis Wait. These diseases directly or indirectly affect people's quality of life and longevity. How to delay aging, maintain immune function, and maintain health has become a hot spot of social concern. [0003] In the prior art, although the research on anti-aging mechanism is diverse, there are few anti-aging products. At present, most anti-aging products on the market are composed of food or traditional Chinese medicine extracts to a certain extent. The effect of human...

Claims

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Application Information

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IPC IPC(8): A61K31/706A61K31/01A61P39/06
CPCA61K31/706A61K31/01A61P39/06A61K2300/00
Inventor 胡浪沈建周亚杰
Owner NANJING ZHONGKE GRP CORP LTD
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