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Composition for treating acne and preparation method thereof

A composition and acne technology, applied in the field of medicine, can solve problems such as single function, poor solubility of cryptotanshinone, and limited anti-acne effect, and achieve the effects of promoting absorption and retention, increasing solubility, and reducing the number of administrations

Active Publication Date: 2022-05-10
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to overcome the defects and deficiencies of existing products such as single function, poor solubility of cryptotanshinone, and limited anti-acne effect, and aims to provide an anti-inflammatory, antibacterial, and anti-lipid effect based on the mechanism of acne formation. , a composition for treating acne that improves the anti-acne effect from various aspects

Method used

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  • Composition for treating acne and preparation method thereof
  • Composition for treating acne and preparation method thereof
  • Composition for treating acne and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1 Preparation of ionic liquid loaded cryptotanshinone (0.5%)-tea polyphenol (5%) complex

[0040] The preparation of ionic liquid: 12g salicylic acid is joined in 12mL dehydrated alcohol, stirring and dissolving, 24g choline hydroxide solution (mass fraction is the aqueous solution of 44%) is slowly added dropwise in salicylic acid ethanol solution, at room temperature Stir for 4 hours. Water and ethanol were removed by rotary evaporation at 50°C, and finally dried in a vacuum oven at 50°C for 48 hours. The solution is a clear light yellow viscous liquid.

[0041] Take 10 g of the ionic liquid obtained above, add 500 mg of tea polyphenols, accelerate dissolution by ultrasonication for 0.5 hours, and continue to add 50 mg of cryptotanshinone. Sonication for 3 hours resulted in complete dissolution, resulting in a clear dark red solution.

Embodiment 2

[0042] Example 2 Preparation of ionic liquid loaded cryptotanshinone (0.1%)-tea polyphenol (1%) complex

[0043] The preparation of the ionic liquid was as in Example 1.

[0044] Take 10 g of the ionic liquid obtained above, add 100 mg of tea polyphenols, accelerate dissolution by ultrasonication for 0.5 hours, and continue to add 10 mg of cryptotanshinone. Sonication for 3 hours resulted in complete dissolution, resulting in a clear red solution.

Embodiment 3

[0045] Example 3 Preparation of Cryptotanshinone (0.1%)-tea polyphenol (5%) complex loaded on ionic liquid

[0046]The preparation of the ionic liquid was as in Example 1.

[0047] Take 10 g of the ionic liquid obtained above, add 500 mg of tea polyphenols, accelerate dissolution by ultrasonication for 0.5 hours, and continue to add 10 mg of cryptotanshinone. Sonication for 3 hours resulted in complete dissolution, resulting in a clear red solution.

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Abstract

The invention discloses a composition for treating acne and a preparation method thereof. The composition comprises cryptotanshinone, tea polyphenol, choline hydroxide and salicylic acid. Various test results prove that the composition of the present invention can effectively treat acne caused by various pathogenesis, and the therapeutic effect is better than that of a single-component drug, showing obvious synergistic effect. At the same time, the invention solves the problems of poor water solubility, percutaneous penetration and poor absorption of cryptotanshinone, etc., and improves the drug concentration in the body.

Description

technical field [0001] The invention relates to the technical field of medicine. More specifically, it relates to a composition for treating acne and a preparation method thereof. Background technique [0002] Acne is a chronic inflammatory skin disease of the pilosebaceous unit. Its clinical manifestations are characterized by pleomorphic skin lesions such as acne, papules, pustules, and nodules on the face. It mainly occurs in adolescents. and social influence. Existing studies have shown that the occurrence of acne is mainly closely related to factors such as abnormal androgen levels, excessive sebum secretion, blockage of pilosebaceous gland ducts, bacterial infection and inflammatory response. When the hormone level of the human body is unbalanced, it can promote the development of sebaceous glands and produce a large amount of sebum. At the same time, the abnormal keratinization of the pilosebaceous gland ducts will cause duct blockage, sebum discharge obstacles, and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/58A61K36/82A61K31/353A61K9/00A61K47/12A61K47/18A61P17/10
CPCA61K36/82A61K31/353A61K31/58A61K9/0014A61K47/12A61K47/186A61P17/10A61K2300/00
Inventor 徐月红汤禹嘉
Owner SUN YAT SEN UNIV
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