Application of radix aconiti carmichaeli polysaccharide to preparation of medicine for resisting radiation or treating ionizing radiation injury

A technology of aconite polysaccharide and ionizing radiation, applied in the field of medicine, can solve the problems of short metabolic half-life, large toxic and side effects, etc.

Inactive Publication Date: 2021-04-23
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, only amifostine (WR2721) is the only anti-radiation damage protection drug approved by the US FDA, but amifostine can only be used as an injection, and it is ineffective when taken orally. The metabolic half-life is very short, and the side effects are relatively large

Method used

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  • Application of radix aconiti carmichaeli polysaccharide to preparation of medicine for resisting radiation or treating ionizing radiation injury
  • Application of radix aconiti carmichaeli polysaccharide to preparation of medicine for resisting radiation or treating ionizing radiation injury
  • Application of radix aconiti carmichaeli polysaccharide to preparation of medicine for resisting radiation or treating ionizing radiation injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1: Liver and kidney toxicity of continuous administration of aconite polysaccharide to mice

[0017] Experimental grouping and administration

[0018] 120 male Balb / c mice of SPF grade, 6-8 weeks old, weighing 20±2 g, were provided by the Experimental Animal Center of Fourth Military Medical University.

[0019] Mice were randomly divided into: normal group, aconite polysaccharide high-dose group 400mg / kg, aconite polysaccharide low-dose group 200mg / kg, 10 mice in each group. The mice in the normal group were fed with normal saline once a day for 7 days in total. In the high-dose group of aconite polysaccharide, the mice were given 400 mg / kg orally once a day for 7 days. In the high-dose group of aconite polysaccharide, the mice were given 200 mg / kg orally once a day for a total of 7 days. On the eighth day, blood was collected from the orbit, centrifuged at 5000 rpm for 10 min to separate the serum, and an automatic biochemical analyzer was used to analyze...

Embodiment 2

[0023] Example 2: Effect of aconite polysaccharide on the survival rate of male BALB / c mice under 8.0 Gy γ-ray irradiation

[0024] (1) Effect of aconite polysaccharide on the survival rate of mice under 8.0Gy γ-ray irradiation

[0025] ①Experimental grouping

[0026] 120 male Balb / c mice of SPF grade, 6-8 weeks old, weighing 20±2 g, were provided by the Experimental Animal Center of Fourth Military Medical University.

[0027] The mice were randomly divided into four groups: normal group, radiation group, WR2721 group, aconite polysaccharide high-dose group 400mg / kg, aconite polysaccharide low-dose group 200mg / kg, 30 mice in each group.

[0028] ②Administration method

[0029] Normal group: 7 days before irradiation, the mice were fed with normal saline once a day. In the WR2721 group, 1 mmol / kg WR2721 was intraperitoneally injected into the mice 24 hours and 0.5 hours before irradiation, twice in total. Aconite polysaccharide high-dose group: 7 days before irradiation, m...

Embodiment 3

[0036] Example 3: Effect of aconite polysaccharide on the ability of mice to resist oxidative damage after 8.0Gy γ-ray irradiation

[0037] The experimental grouping, dosage and irradiation conditions of this detection are all the same as those in Example 2. After irradiation, the mice in each group were fed for 6 days. On the 7th day after irradiation, the mice were weighed and killed by cervical dislocation. The liver was taken out, and the tissue homogenate was made with a homogenizer, and the supernatant was centrifuged to test the activity of SOD enzyme. and MDA content. Enzyme activity is expressed in U / mg or U / μg.

[0038] Such as image 3 As shown, the effect of aconite polysaccharide on the ability of irradiated mice to resist oxidative damage compared with the normal group, **P Figure 4 As shown, it means the effect of aconite polysaccharide on the anti-oxidative damage ability of mice after radiation. Compared with the normal group, **P<0.01; compared with the irr...

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Abstract

The invention discloses an application of radix aconiti carmichaeli polysaccharide to preparation of a medicine for resisting radiation or treating ionizing radiation injury. The radix aconiti carmichaeli polysaccharide is used for protecting radiation injury and has a better radiation injury resisting effect at an animal level.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of polysaccharide extract aconite polysaccharide in protection against radiation damage. Background technique [0002] With the development of modern high technology, nuclear technology is more and more widely used in human production and life, such as nuclear power plants, nuclear weapons, aerospace fields, medical testing, etc. However, the application of nuclear technology will produce ionizing radiation, which, as an "invisible pollution source", seriously threatens human health in many fields. At present, only amifostine (WR2721) is the only anti-radiation damage protection drug approved by the US FDA, but amifostine can only be used as an injection, and it is ineffective when taken orally. The metabolic half-life is very short, and the side effects are relatively large. Therefore, there is still an urgent need for low-toxicity and high-efficien...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61P17/16A61P39/00A61K36/714
CPCA61K31/715A61P17/16A61P39/00A61K36/714
Inventor 王海波谭光国张雅周倩金卓然
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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