Application of combination of lactobacillus plantarum NA136 and cannabidiol monomer in preparation of product for treating rheumatoid arthritis

A technology of cannabidiol monomer, Lactobacillus plantarum, applied in the direction of bacteria used in food preparation, Lactobacillus, application, etc., to achieve the effect of reducing inflammation, increasing levels, reducing and cartilage degeneration

Active Publication Date: 2021-05-07
JILIN ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a combination of Lactobacillus plantarum NA136 and cannabidiol monomer in the pre

Method used

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  • Application of combination of lactobacillus plantarum NA136 and cannabidiol monomer in preparation of product for treating rheumatoid arthritis
  • Application of combination of lactobacillus plantarum NA136 and cannabidiol monomer in preparation of product for treating rheumatoid arthritis
  • Application of combination of lactobacillus plantarum NA136 and cannabidiol monomer in preparation of product for treating rheumatoid arthritis

Examples

Experimental program
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Effect test

Embodiment 1

[0057] Example 1 Effects of Lactobacillus plantarum NA136 strain, cannabidiol monomer, the composition of Lactobacillus plantarum NA136 strain and cannabidiol monomer on collagen-type arthritis model rats

[0058] 1. Establishment and grouping of animal models

[0059] Calf cartilage type Ⅱ collagen plus Freund's incomplete adjuvant was used as a modeling agent after being fully emulsified. 20 mg of bovine type Ⅱ collagen was dissolved in 10 mL of acetic acid with a concentration of 0.1 mol / L. Adjuvant fully emulsified.

[0060] The first immunization: 150 μL of modeling agent was injected subcutaneously at a distance of 1.5 cm from the base of the rat tail.

[0061] The second immunization: 7 days later, the same treatment method was used for booster immunization, that is, 150 μL of modeling agent was injected subcutaneously at a distance of 2.0 cm from the base of the tail of the rats. One week after the booster immunization, the redness and swelling of the paws and ankle ...

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Abstract

The invention discloses application of a combination of lactobacillus plantarum NA136 and a cannabidiol monomer in preparation of a product for treating rheumatoid arthritis, and belongs to the field of functional food microorganisms. The concentration of the lactobacillus plantarum NA136 is 2*10 <9>-2*10 <10> CFU; the concentration of cannabidiol monomer is 2.4 mg/mL; and the lactobacillus plantarum NA136 and the cannabidiol monomer are used separately. Tests prove that the joint application of the lactobacillus plantarum NA136 strain and the cannabidiol monomer can relieve the arthritis symptom of rats; bone erosion and cartilage degeneration are reduced; the product can reduce inflammatory reaction, reduce the levels of inflammatory factors IL-17 and TNF-alpha, and improve the level of an anti-inflammatory factor IL-10; and the content of lipopolysaccharide in serum is reduced. During the onset of rheumatoid arthritis, the immunoglobulin IgG level is reduced. The composition has the effect of preventing and/or treating rheumatoid arthritis.

Description

technical field [0001] The invention belongs to the technical field of functional food microorganisms, and in particular relates to the application of a combination of Lactobacillus plantarum NA136 and cannabidiol monomer in the preparation of products for treating rheumatoid arthritis. Background technique [0002] Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease characterized by joint pain, joint capsule swelling, and lesions. The occurrence and development of RA are related to the release of a large number of inflammatory cytokines and inflammatory mediators. The main pathological change is chronic synovitis, which gradually manifests as cartilage and bone destruction, eventually leading to joint deformity and even loss of joint function in patients. Epidemiological surveys show that about 0.5-1% of the world's population suffers from rheumatoid arthritis, and the prevalence in my country is about 0.32-0.36%. [0003] Clinically, there is currently no ...

Claims

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Application Information

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IPC IPC(8): A61K35/747A61P19/02A61P29/00A23L33/135A23L33/105A61K31/05
CPCA61K35/747A61K31/05A61P19/02A61P29/00A23L33/135A23L33/105A23V2002/00A23V2400/169A61K2300/00A23V2200/30A23V2250/2132A23V2300/14
Inventor 吴兴宏李盛钰赵子健赵玉娟王超杨舸高磊
Owner JILIN ACAD OF AGRI SCI
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