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Application of oxymatrine in reducing epidermal cell death caused by lipotoxicity of psoriasis patient

A technology of oxymatrine and epidermal cells, applied in the field of medicine, can solve the problems of poorly understood metabolic changes of psoriasis

Pending Publication Date: 2021-05-28
GENERAL HOSPITAL OF NINGXIA MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, little is known about metabolic changes in the psoriatic condition

Method used

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Experimental program
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Effect test

Embodiment Construction

[0032] The application of oxymatrine in reducing epidermal cell death caused by lipotoxicity in patients with psoriasis comprises the following steps:

[0033] (2) Collection of patient information

[0034] From December 2018 to May 2019, the inventor recruited 32 patients and 29 healthy volunteers who were clinically or histologically diagnosed with severe plaque psoriasis in the Outpatient Department of Ningxia Medical University General Hospital. All patients were administered Tianqing Fuxin (oxymatrine >98%, 0.6g (100mL) / d) according to the clinical trial registration guidelines of China Jiangsu Jiatai Tianqing Pharmaceutical Group Co., Ltd. (CHICCTR-TRc-14004301). 8 weeks in total. The severity of psoriasis patients was quantified using the Psoriasis Area and Severity Index (PASI) score, Psoriasis Global Assessment (PGA) score, and Body Surface Area (BSA) score. In addition, the Dermatology Life Quality Index (DLQI) questionnaire was used to measure how much skin proble...

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PUM

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Abstract

The invention discloses application of oxymatrine in reducing epidermal cell death caused by lipotoxicity of a psoriasis patient, which comprises the steps of patient information collection, collection and preparation of a metabonomics research sample, preparation of a lipidomics research sample, LC-MS metabonomics data collection, GC-MS metabonomics data collection, LC-MS / MS lipidomics data collection, LC-MS and GC-MS metabonomics data analysis, quantitative lipidomics data analysis, cell culture and cell viability determination, protein imprinting, and statistical analysis. By combining metabonomics and lipidomics, the change of the overall skin metabolism homeostasis of the psoriasis patient is revealed, the mechanism of treating psoriasis by oxymatrine is answered, the effectiveness and safety of treating psoriasis by oxymatrine are fully represented, a new mechanism is provided for the development of psoriasis, and an effective compound oxymatrine is provided for effective and long-term clinical treatment of psoriasis.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an application of oxymatrine in reducing epidermal cell death caused by lipotoxicity in patients with psoriasis. Background technique [0002] Psoriasis is a major global health problem with a prevalence of approximately 2% worldwide. Symptoms of psoriasis include red patches of skin covered with thick and elongated scales, itchy, burning, and even cracked skin. People with psoriasis are at high risk for other conditions, such as psoriatic arthritis, metabolic syndrome, cardiovascular disease, anxiety and depression, which further reduce quality of life. With careful treatment, even when symptoms are manageable, the severity of psoriasis can still fluctuate over time in the presence of medications. Clinical treatments for psoriasis include topical medications, oral medications, phototherapy, and biologics. Major considerations for these treatments include issues o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4375A61P17/06
CPCA61K31/4375A61P17/06
Inventor 施惠娟陈冬梅
Owner GENERAL HOSPITAL OF NINGXIA MEDICAL UNIV
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