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Preparation method of bluetongue virus bivalent inactivated vaccine

A bivalent inactivated vaccine and bluetongue virus technology, applied in the field of bluetongue virus bivalent inactivated vaccine, can solve the problems of poor immune effect, indistinguishable vaccine immunity and wild strain infection, etc. The vaccine preparation method is simple and feasible, and the effect of improving the immune efficiency and effect

Pending Publication Date: 2021-06-01
YUNNAN ANIMAL SCI & VETERINARY INST
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] In view of this, on the premise of not significantly increasing the production cost, the present invention establishes unique bluetongue virus culture, inactivation, concentration and purification, and virus strain ratio process, and improves adjuvant, excipient and inactivated antigen suspension. The combination of liquid, obtain bluetongue virus bivalent inactivated vaccine production process, solve the bluetongue inactivated vaccine immune effect is poor, indistinguishable vaccine immunity and wild strain infection problems

Method used

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  • Preparation method of bluetongue virus bivalent inactivated vaccine
  • Preparation method of bluetongue virus bivalent inactivated vaccine
  • Preparation method of bluetongue virus bivalent inactivated vaccine

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Embodiment Construction

[0040] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some of the embodiments of the present invention, but not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0041] The present invention proposes a new bluetongue virus culture, inactivation, purification and concentration, and proportioning process, combined with the combination of adjuvant, excipient and inactivated antigen suspension, to achieve efficient induction of ruminants to simultaneously produce anti-type 1 and The immune response of bluetongue virus type 16 can effectively remove the interference of non-structural proteins, and realize the distinguishable identification of vaccine immunity and wild strain infection.

[0042] T...

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Abstract

The invention belongs to the technical field of research and development of biological product preparation processes, and discloses a preparation method of a bluetongue virus bivalent inactivated vaccine, which comprises the steps of virus culture, inactivator preparation, inactivation operation, concentration and purification, antigen emulsification, vaccine proportioning and the like. According to the invention, the adjuvant, the excipient and the inactivated antigen suspension are combined, the ruminant is efficiently induced, the immune response to the bluetongue virus is generated, the interference of the non-structural protein is effectively removed, and the distinguishable identification of the vaccine immunity and the wild strain infection is achieved.

Description

technical field [0001] The invention relates to the technical field of biological product preparation technology research and development, and specifically discloses a bivalent inactivated bluetongue virus vaccine capable of producing protective immune responses in ruminants and capable of distinguishing vaccine immunity from wild strain infection. Background technique [0002] Bluetongue (BT) is a non-contact viral infectious disease caused by bluetongue virus (BTV) and is transmitted by arthropod insects. It is mainly distributed in tropical, subtropical and temperate regions and mainly infects ruminants such as sheep. , Most animals are recessively infected after infection, and do not show clinical symptoms. Symptoms such as fetal malformation, stillbirth and miscarriage may occur in pregnant animals after infection. Currently, at least 27 serotypes of bluetongue virus have been found, among which the main epidemic strains in my country are type 1 and type 16. [0003] I...

Claims

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Application Information

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IPC IPC(8): A61K39/295A61K39/15A61K39/39A61P31/14C12N7/00C12N7/06C12R1/93
CPCA61K39/12A61K39/39A61P31/14C12N7/00A61K2039/5252A61K2039/70A61K2039/552A61K2039/55511C12N2720/12151C12N2720/12134C12N2720/12163
Inventor 苗海生李乐寇美玲谢佳芮廖德芳李华春
Owner YUNNAN ANIMAL SCI & VETERINARY INST
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