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A kind of peach gum extract and its preparation method and application

A technology of extract and peach gum, which is applied in the field of peach gum extract and its preparation, can solve the problems that the safety of surfactants cannot be guaranteed at the same time, and achieve the goal of reducing skin adverse reactions, inhibiting the hemolysis inhibition rate of red blood cells, and reducing irritation Effect

Active Publication Date: 2022-03-25
BEIJING ACAD OF TCM BEAUTY SUPPLEMENTS +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above methods cannot guarantee the functional performance and safety of use of surfactants at the same time.

Method used

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  • A kind of peach gum extract and its preparation method and application
  • A kind of peach gum extract and its preparation method and application
  • A kind of peach gum extract and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0124] Embodiment 1, anti-surfactant stimulates raw material screening

[0125] The present invention screens a variety of Chinese medicine raw materials and compounds that claim to have anti-stimulation and extracts them, and through the red blood cell hemolysis and coagulation test, investigates the antagonistic effect of each Chinese medicine extract on the red blood cell stimulation caused by SDS.

[0126] The present invention also investigated the antagonistic effect of different polysaccharides and three competing products on the red blood cell stimulation caused by SDS.

[0127] Table 1 Sources of raw materials used

[0128]

[0129]

[0130] Market Competitor 1 Ingredients: Butylene Glycol, Water, Centella Asiatica (Centella Asiatica) Extract, Polygonum Cuspidatum Root Extract, Scutellaria Baicalensis Root Extract, Tea (Camellia Sinensis) Leaf Extract, Light Glycyrrhiza Glabra Root Extract, Chamomilla Recutita Flower Extract, Rosemary (Rosmarinus Officinalis) L...

Embodiment 2

[0167] Preparation process:

[0168] According to peach gum: water = 1:20 (m / m), extract with pure water, extract at 70°C for 1.5h; centrifuge at 5000rpm / min for 10min, take the supernatant; use a 50nm microfiltration membrane module for microfiltration and concentration, remove For substances with a molecular weight below 50wDa in the supernatant, retain the effluent to obtain a microfiltrate; add the microfiltrate and 95% ethanol at a ratio of 1: 10 (m / v), stir evenly, and after standing at room temperature for 12 hours, take out the precipitated substance; Freeze-dry at -80°C for 10 hours; pulverize; sterilize at 120°C for 1 hour to obtain peach gum macromolecular polysaccharide extract.

Embodiment 3

[0170] Preparation process:

[0171] According to peach gum: water = 1:10, extract with pure water, extract at 80°C for 0.5h, centrifuge at 4000-8000rpm for 25min, and take the supernatant; use a 50nm microfiltration membrane module to perform microfiltration and concentration, and remove the molecular weight in the supernatant For substances below 50wDa, keep the effluent to obtain the microfiltrate; add the microfiltrate and 95% ethanol at a ratio of 1:5 (m / v), stir evenly, and after standing at room temperature for 10h, take out the precipitated substance and freeze at -50°C Dry for 32 hours, pulverize, and sterilize at 140°C for 0.5 hours to obtain peach gum macromolecular polysaccharide extract.

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Abstract

The invention provides a peach gum extract, which comprises more than 30% of peach gum polysaccharides in terms of mass content, and the average molecular weight of the peach gum polysaccharides is 100-500wDa. The invention also provides a preparation method of the peach gum extract. The peach gum extract provided by the invention has a significant effect of antagonizing the irritation of surfactants. The present invention also provides an application of polysaccharide and / or plant extract in the preparation of products for antagonizing the irritation of surfactants.

Description

technical field [0001] The invention relates to a peach gum extract and its preparation method and application. Background technique [0002] Surfactants have multiple functions such as dispersion, decontamination, solubilization and penetration, and are widely used in various detergents and cleaning compositions to impart their cleaning properties, and are an important part of cosmetics. Surfactants can be divided into ionic surfactants and nonionic surfactants according to the characteristics of molecular composition and the dissociation properties of polar groups. [0003] The irritation or sensitization of surfactants to the skin or mucous membranes is mainly reflected in three aspects: (1) Dissolution: the dissolution of surfactants on the skin's own moisturizing ingredients, intercellular lipids, and free amino acids and fats in the stratum corneum. Dissolution degree. Surfactants will affect the degree of dissolution of the skin's own moisturizing ingredients (such ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/9789A61K8/73A61K8/9794A61K8/9728A61Q19/00A61Q19/10A61Q5/02A61Q5/12
CPCA61K8/9789A61K8/73A61K8/9794A61K8/9728A61Q19/00A61Q19/10A61Q5/02A61Q5/12A61K2800/596
Inventor 孟宏刘有停苏牧楠曲召辉刘宇红刘月恒
Owner BEIJING ACAD OF TCM BEAUTY SUPPLEMENTS
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