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A kind of anti-irritant composition and its application

A composition and anti-irritation technology, which is applied in the field of anti-irritation composition, can solve the problems that the safety of surfactants cannot be guaranteed at the same time, and achieve the effect of reducing skin adverse reactions and reducing irritation

Active Publication Date: 2022-07-29
BEIJING ACAD OF TCM BEAUTY SUPPLEMENTS +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above methods cannot guarantee the function and safety of the surfactant at the same time.

Method used

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  • A kind of anti-irritant composition and its application
  • A kind of anti-irritant composition and its application
  • A kind of anti-irritant composition and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] Example 1. Screening of raw materials against surfactant stimulation

[0077] In the present invention, a variety of raw materials and compounds claimed to have anti-stimulation properties are screened for extraction, and the antagonism effect of each extract on the erythrocyte stimulation caused by SDS is investigated through red blood cell hemolysis and coagulation test.

[0078] The present invention also investigates the antagonistic effects of different anionic polysaccharides and three market competing products on the erythrocyte stimulation caused by SDS.

[0079] Table 1 Source of raw materials used

[0080] raw material name Standard Chinese name buy manufacturers peach gum / Xiangyang Tianma Zhonghe Trading Co., Ltd. cactus / Zhengzhou Gebei Import & Export Trading Co., Ltd. oat bran / Zhangjiakou Beiyan Oat Food Development Co., Ltd. Tremella / Beijing Tongrentang purslane / Beijing Tongrentang chamom...

Embodiment 2

[0120] 3 parts of peach gum, 1 part of cactus, add 50 parts of pure water, extract with pure water, and extract at 70 °C for 2 hours; centrifuge at 5000 rpm for 10 min, and take the supernatant; use a 50 nm microfiltration membrane module for microfiltration and concentration, and remove the supernatant For substances with a middle molecular weight below 50wDa, the effluent is retained to obtain a microfiltrate.

Embodiment 3

[0122] 10 parts of peach gum, 5 parts of cactus, added 100 parts of pure water, extracted with pure water, extracted at 80 °C for 0.5 h; centrifuged at 4000 rpm for 30 min, and took the supernatant; use a 50 nm microfiltration membrane module for microfiltration and concentration, and remove the supernatant Substances with a molecular weight below 50wDa in the liquid are retained in the effluent to obtain a microfiltrate.

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Abstract

The present invention relates to a composition and its application, said composition comprising peach gum extract and cactus extract. The composition of the present invention has a significant effect of antagonizing the irritation of surfactants. Efficacy evaluation experiments confirmed that the composition of the present invention has a significant inhibitory effect on erythrocyte hemolysis caused by surfactants, significantly reduces the irritation of the chicken embryo chorioallantoic membrane caused by surfactants, and can effectively improve the skin texture caused by surfactants. It can significantly improve the disorder of skin lipid arrangement caused by surfactants, and significantly reduce the adverse reactions of different surfactants to human skin.

Description

technical field [0001] The invention relates to the field of daily cosmetics, in particular to an anti-irritant composition and application thereof. Background technique [0002] Surfactants have various functions such as dispersing, detergency, solubilization and penetration, and are widely used in various detergents and cleaning compositions to impart their cleaning properties, and are an important part of cosmetics. According to the characteristics of molecular composition and the dissociation properties of polar groups, surfactants can be divided into ionic surfactants and nonionic surfactants. [0003] The irritation or sensitization of surfactants to the skin or mucous membranes is mainly reflected in three aspects: (1) Dissolution: the effect of surfactants on the skin's own moisturizing components, intercellular lipids, and free amino acids and fats in the stratum corneum. degree of dissolution. Surfactants will affect the dissolution of the skin's own moisturizing...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/9789A61K8/73A61K8/44A61K8/60A61K8/41A61K8/86A61Q19/00A61Q5/02A61Q19/10A61Q5/12
CPCA61K8/9789A61K8/73A61K8/442A61K8/602A61K8/416A61K8/86A61K8/44A61Q19/00A61Q5/02A61Q19/10A61Q5/12A61K2800/596
Inventor 孟宏苏牧楠曲召辉刘有停刘宇红刘月恒
Owner BEIJING ACAD OF TCM BEAUTY SUPPLEMENTS
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