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A kind of anti-irritant composition and its preparation method and application

An anti-irritation and composition technology, applied in the field of anti-irritation composition, can solve problems such as skin irritation, achieve the effect of simple material composition, reduce chicken embryo chorioallantoic membrane irritation, and increase the hemolysis inhibition rate of erythrocytes

Active Publication Date: 2022-03-11
BEIJING DONGFANG MIAOSEN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But it only addresses skin irritation caused by surfactants in cosmetics

Method used

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  • A kind of anti-irritant composition and its preparation method and application
  • A kind of anti-irritant composition and its preparation method and application
  • A kind of anti-irritant composition and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Peach gum 3g, cactus 1g, centella asiatica 1g, psyllium 0.1g, according to the total raw material: water = 1:40 (m / m), add 204g of water, extraction temperature 80 ℃, extract for 2h, filter, and concentrate the weight of the filtrate 1 times; based on the weight of the concentrate, compounded with 24% glycerin, 9% trehalose, 9% hydroxypropyl-β-cyclodextrin, 1% hexanediol, 2% pentylene glycol, 0.2% disodium EDTA, 0.05% xanthan gum, sterilized at 90° C. for 40 minutes to obtain the anti-irritant composition of Example 1.

Embodiment 2

[0062] Peach gum 10g, cactus 5g, centella asiatica 5g, psyllium 1g, according to the total raw material: water = 1:30 (m / m), add water 630g, extraction temperature 70°C, extract for 3h, filter, and concentrate the weight of the filtrate for 2 times; based on the weight of the concentrate, compounded with 20% glycerin, 8% trehalose, 5% β-cyclodextrin, 1.5% hexanediol, 1.5% pentanediol, 0.5% disodium EDTA, 0.1% xanthan gum , sterilized at 100° C. for 30 minutes to obtain the anti-irritant composition of Example 2.

Embodiment 3

[0064] Peach gum 15g, cactus 7g, centella asiatica 5g, psyllium 3g, according to the total raw material: water = 1:50 (m / m), add water 1500g, extraction temperature 50 ℃, extract 5h, filter, and concentrate the weight of the filtrate for 3 times; based on the weight of the concentrate, compound 10% glycerin, 20% trehalose, 20% hydroxypropyl-β-cyclodextrin, 1% hexanediol, 2% pentanediol, 0.5% disodium EDTA, 0.1 % xanthan gum, sterilized at 100° C. for 30 min to obtain the anti-irritant composition of Example 3.

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Abstract

The invention discloses an anti-irritant composition, its preparation method and application. The anti-irritant composition includes peach gum, cactus, centella asiatica, and plantain seed, has simple material composition, simple preparation process, and interactions between components, and can effectively resist skin irritation caused by cosmetic raw materials. Efficacy evaluation experiments have confirmed that the anti-irritant composition of the present invention can antagonize the stimulation of lactic acid, increase the inhibition rate of erythrocyte hemolysis caused by sodium dodecyl sulfate (SDS), reduce the stimulation of chicken embryo chorioallantoic membrane caused by SDS, and antagonize various stimulus. It is expected to have anti-irritant effect when applied in cosmetics, and can antagonize skin irritation caused by various irritants in cosmetic raw materials such as acidic substances, surfactants, flavors and fragrances, and preservatives.

Description

technical field [0001] The invention relates to an anti-irritant composition and its preparation method and application. Background technique [0002] With the continuous improvement of living standards, people's pursuit of beauty and skin care is also getting higher and higher. In recent years, the production and consumption of cosmetics in my country have increased sharply, and the resulting skin adverse reactions are increasing day by day, which has aroused widespread concern. Adverse skin reactions to cosmetics have become a common disease in dermatology. In my country, a total of 13,534 patients with cosmetic adverse reactions were reported from 2005 to 2014, of which women accounted for 95.40%, young and middle-aged patients (20-44 years old) accounted for 80.85%, and 5,446 confirmed cases. The lesion type was cosmetic adverse reaction contact dermatitis. Mainly (94.66%), there were 132 other lesion types not included in the diagnostic criteria, and the confirmed case...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/9789A61Q19/00A61Q19/10
CPCA61K8/9789A61Q19/00A61Q19/10A61K2800/75A61K2800/5922
Inventor 刘有停苏牧楠吕永博
Owner BEIJING DONGFANG MIAOSEN BIOTECH CO LTD
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